Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           20     509
NP_000242                                                              20     509
XP_005264389                                                           20     509
NP_001078823                                                           17    3301
NP_078933                                                              17    3301
XP_006724755                                                           17    3301
XP_005262247                                                           17    3301
NP_004897                                                              17    4312
NP_001257460                                                           17    4312
NP_057726                                                              16    5631
NP_001018098                                                           16    5631
NP_060154                                                              16    5631
NP_060550                                                              16    5631
NP_065872                                                              16    5631
NP_001273701                                                           16    5631
NP_060671                                                              16    5631
NP_054861                                                              16    5631
XP_005254495                                                           16    5631
XP_005252117                                                           16    5631
XP_006717210                                                           16    5631
NP_005531                                                              16    7355
NP_001034456                                                           16    7355
NP_001034455                                                           16    7355
NP_001687                                                              16    7355
NP_071934                                                              16    7355
NP_001026884                                                           16    7355
XP_005268062                                                           16    7355
XP_005268061                                                           16    7355
XP_005271929                                                           16    7355
XP_005270894                                                           16    7355
XP_005270892                                                           16    7355
NP_001275                                                              16    7355
NP_060493                                                              15    9605
XP_006713751                                                           15    9605
XP_005247655                                                           15    9605
XP_005247654                                                           15    9605
NP_112486                                                              15    9605
>NP_001245210
          Length = 868

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           NDVL QLDA
Sbjct: 530 NDVLAQLDA 538
>NP_000242
          Length = 934

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           NDVL QLDA
Sbjct: 596 NDVLAQLDA 604
>XP_005264389
          Length = 921

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           NDVL QLDA
Sbjct: 596 NDVLAQLDA 604
>NP_001078823
          Length = 900

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NDVLVQLDA 9
           ND+L Q DA
Sbjct: 201 NDLLAQFDA 209
>NP_078933
          Length = 937

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NDVLVQLDA 9
           ND+L Q DA
Sbjct: 201 NDLLAQFDA 209
>XP_006724755
          Length = 532

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NDVLVQLDA 9
           ND+L Q DA
Sbjct: 201 NDLLAQFDA 209
>XP_005262247
          Length = 845

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   NDVLVQLDA 9
           ND+L Q DA
Sbjct: 109 NDLLAQFDA 117
>NP_004897
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           ND ++QLD
Sbjct: 205 NDFIIQLD 212
>NP_001257460
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           ND ++QLD
Sbjct: 205 NDFIIQLD 212
>NP_057726
          Length = 3674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    DVLVQLDA 9
            DVL+QL+A
Sbjct: 1018 DVLLQLEA 1025
>NP_001018098
          Length = 3628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NDVLVQLDA 9
            + VLVQ+DA
Sbjct: 2524 DSVLVQIDA 2532
>NP_060154
          Length = 3710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NDVLVQLDA 9
            + VLVQ+DA
Sbjct: 2481 DSVLVQIDA 2489
>NP_060550
          Length = 3585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NDVLVQLDA 9
            + VLVQ+DA
Sbjct: 2481 DSVLVQIDA 2489
>NP_065872
          Length = 3753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    NDVLVQLDA 9
            + VLVQ+DA
Sbjct: 2524 DSVLVQIDA 2532
>NP_001273701
          Length = 275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NDVLVQLD 8
           N+VL+Q+D
Sbjct: 117 NEVLLQID 124
>NP_060671
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NDVLVQLD 8
           N+VL+Q+D
Sbjct: 117 NEVLLQID 124
>NP_054861
          Length = 219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           ND+L +LDA
Sbjct: 176 NDLLQRLDA 184
>XP_005254495
          Length = 3694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    DVLVQLDA 9
            DVL+QL+A
Sbjct: 1038 DVLLQLEA 1045
>XP_005252117
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  NDVLVQLD 8
          N+VL+Q+D
Sbjct: 41 NEVLLQID 48
>XP_006717210
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NDVLVQLD 8
           N+VL+Q+D
Sbjct: 117 NEVLLQID 124
>NP_005531
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           +DV VQLD
Sbjct: 95  SDVTVQLD 102
>NP_001034456
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           NDV VQ+D
Sbjct: 131 NDVDVQID 138
>NP_001034455
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           NDV VQ+D
Sbjct: 139 NDVDVQID 146
>NP_001687
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           NDV VQ+D
Sbjct: 161 NDVDVQID 168
>NP_071934
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVLVQLDA 9
           D+L+QL+A
Sbjct: 240 DLLIQLEA 247
>NP_001026884
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVLVQLDA 9
           D+L+QL+A
Sbjct: 240 DLLIQLEA 247
>XP_005268062
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVLVQLDA 9
           D+L+QL+A
Sbjct: 272 DLLIQLEA 279
>XP_005268061
          Length = 1281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVLVQLDA 9
           D+L+QL+A
Sbjct: 272 DLLIQLEA 279
>XP_005271929
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           N+++ Q+DA
Sbjct: 235 NEIVTQIDA 243
>XP_005270894
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           +DV VQLD
Sbjct: 95  SDVTVQLD 102
>XP_005270892
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NDVLVQLD 8
           +DV VQLD
Sbjct: 95  SDVTVQLD 102
>NP_001275
          Length = 193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NDVLVQLDA 9
           N+++ Q+DA
Sbjct: 135 NEIVTQIDA 143
>NP_060493
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVLVQLDA 9
            DVL Q+D+
Sbjct: 1252 DVLTQIDS 1259
>XP_006713751
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVLVQLDA 9
            DVL Q+D+
Sbjct: 1253 DVLTQIDS 1260
>XP_005247655
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVLVQLDA 9
            DVL Q+D+
Sbjct: 1253 DVLTQIDS 1260
>XP_005247654
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVLVQLDA 9
            DVL Q+D+
Sbjct: 1253 DVLTQIDS 1260
>NP_112486
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   NDVLVQLD 8
           +D+++QLD
Sbjct: 152 SDIIMQLD 159
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.137    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 372,795
Number of extensions: 594
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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