Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              21     229
XP_005262424                                                           21     229
NP_001239586                                                           18    1135
XP_006713052                                                           18    1135
XP_006713051                                                           18    1135
NP_061119                                                              18    1482
NP_613258                                                              18    1482
NP_613075                                                              18    1482
NP_001035248                                                           18    1482
NP_004884                                                              18    1482
XP_005272192                                                           18    1482
XP_005272191                                                           18    1482
XP_005272189                                                           18    1482
NP_001185771                                                           18    1935
NP_006422                                                              18    1935
NP_000129                                                              17    3301
NP_036205                                                              17    3301
NP_004317                                                              17    4312
XP_005277475                                                           17    4312
XP_005277474                                                           17    4312
XP_006711546                                                           17    4312
XP_005273028                                                           17    4312
NP_006493                                                              16    5631
NP_001138890                                                           16    5631
XP_006724234                                                           16    5631
XP_005261462                                                           16    5631
XP_006715181                                                           16    5631
XP_005249243                                                           16    5631
NP_060644                                                              16    5631
NP_001005284                                                           16    5631
NP_000072                                                              16    7355
NP_000382                                                              16    7355
NP_000055                                                              16    7355
NP_005132                                                              16    7355
NP_001171670                                                           16    7355
NP_001167522                                                           16    7355
NP_006021                                                              16    7355
NP_001278030                                                           16    7355
NP_001005505                                                           16    7355
NP_037384                                                              16    7355
NP_057036                                                              16    7355
XP_005250022                                                           16    7355
XP_005265638                                                           16    7355
XP_005273087                                                           16    7355
XP_006711794                                                           16    7355
XP_005273086                                                           16    7355
XP_005273085                                                           16    7355
XP_005273084                                                           16    7355
NP_057336                                                              15    9605
NP_006421                                                              15    9605
NP_000304                                                              15    9605
NP_006420                                                              15    9605
NP_001159757                                                           15    9605
NP_110379                                                              15    9605
XP_006723584                                                           15    9605
XP_006723583                                                           15    9605
XP_006723582                                                           15    9605
XP_005247683                                                           15    9605
XP_006712120                                                           15    9605
XP_005264512                                                           15    9605
XP_005264511                                                           15    9605
XP_006712119                                                           15    9605
XP_005264510                                                           15    9605
XP_006712118                                                           15    9605
XP_005264509                                                           15    9605
XP_005264508                                                           15    9605
XP_006712117                                                           15    9605
XP_005264507                                                           15    9605
XP_005264506                                                           15    9605
XP_006710114                                                           15    9605
>NP_722576
          Length = 3080

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NDGFTVLSN 9
            NDGFTVLS+
Sbjct: 1475 NDGFTVLSD 1483
>XP_005262424
          Length = 2875

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NDGFTVLSN 9
            NDGFTVLS+
Sbjct: 1270 NDGFTVLSD 1278
>NP_001239586
          Length = 630

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NDGFTVLSN 9
           ND FTV+SN
Sbjct: 186 NDKFTVVSN 194
>XP_006713052
          Length = 396

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NDGFTVLSN 9
           ND FTV+SN
Sbjct: 186 NDKFTVVSN 194
>XP_006713051
          Length = 618

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   NDGFTVLSN 9
           ND FTV+SN
Sbjct: 186 NDKFTVVSN 194
>NP_061119
          Length = 372

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   DGFTVLSN 9
           DGFT+LS+
Sbjct: 181 DGFTILSS 188
>NP_613258
          Length = 372

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 181 DGFTVLS 187
>NP_613075
          Length = 369

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 181 DGFTVLS 187
>NP_001035248
          Length = 371

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 180 DGFTVLS 186
>NP_004884
          Length = 371

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 180 DGFTVLS 186
>XP_005272192
          Length = 198

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 180 DGFTVLS 186
>XP_005272191
          Length = 199

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 181 DGFTVLS 187
>XP_005272189
          Length = 368

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   DGFTVLS 8
           DGFTVLS
Sbjct: 180 DGFTVLS 186
>NP_001185771
          Length = 488

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NDGFTVLSN 9
          NDG T+L N
Sbjct: 18 NDGATILKN 26
>NP_006422
          Length = 535

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NDGFTVLSN 9
          NDG T+L N
Sbjct: 65 NDGATILKN 73
>NP_000129
          Length = 2871

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    NDGFTVLSN 9
            NDGFT   N
Sbjct: 2319 NDGFTASPN 2327
>NP_036205
          Length = 541

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  NDGFTVLS 8
          NDG T+LS
Sbjct: 72 NDGATILS 79
>NP_004317
          Length = 1426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DGFTVLSN 9
            D FTVL N
Sbjct: 1202 DSFTVLGN 1209
>XP_005277475
          Length = 1352

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DGFTVLSN 9
            D FTVL N
Sbjct: 1128 DSFTVLGN 1135
>XP_005277474
          Length = 1414

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DGFTVLSN 9
            D FTVL N
Sbjct: 1190 DSFTVLGN 1197
>XP_006711546
          Length = 1426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DGFTVLSN 9
            D FTVL N
Sbjct: 1202 DSFTVLGN 1209
>XP_005273028
          Length = 1426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    DGFTVLSN 9
            D FTVL N
Sbjct: 1202 DSFTVLGN 1209
>NP_006493
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NDGFTVLSN 9
           +D FTV+ N
Sbjct: 397 HDAFTVIKN 405
>NP_001138890
          Length = 2481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DGFTVLSN 9
            +GF+++SN
Sbjct: 2057 EGFSIISN 2064
>XP_006724234
          Length = 2363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DGFTVLSN 9
            +GF+++SN
Sbjct: 1939 EGFSIISN 1946
>XP_005261462
          Length = 2473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DGFTVLSN 9
            +GF+++SN
Sbjct: 2049 EGFSIISN 2056
>XP_006715181
          Length = 561

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NDGFTVLSN 9
           +D FTV+ N
Sbjct: 245 HDAFTVIKN 253
>XP_005249243
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NDGFTVLSN 9
           +D FTV+ N
Sbjct: 335 HDAFTVIKN 343
>NP_060644
          Length = 1059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DGFTVLSN 9
           +GFTVL N
Sbjct: 259 NGFTVLVN 266
>NP_001005284
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   GFTVLSN 9
           GFTVLS+
Sbjct: 219 GFTVLSS 225
>NP_000072
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 2373 NRGFSLLAN 2381
>NP_000382
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NDGFTVLSN 9
           +DG+ V+SN
Sbjct: 456 SDGYWVVSN 464
>NP_000055
          Length = 1663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NDGFTV 6
            N+GFTV
Sbjct: 1327 NEGFTV 1332
>NP_005132
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NDGFTVLSN 9
           N G+TV+ N
Sbjct: 276 NGGWTVIQN 284
>NP_001171670
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   NDGFTVLSN 9
           N G+TV+ N
Sbjct: 217 NGGWTVIQN 225
>NP_001167522
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GFTVLSN 9
           GF VLSN
Sbjct: 897 GFLVLSN 903
>NP_006021
          Length = 1143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GFTVLSN 9
           GF VLSN
Sbjct: 890 GFLVLSN 896
>NP_001278030
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GFTVLSN 9
           GF VLSN
Sbjct: 821 GFLVLSN 827
>NP_001005505
          Length = 1145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GFTVLSN 9
           GF VLSN
Sbjct: 890 GFLVLSN 896
>NP_037384
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NDGFT 5
          NDGFT
Sbjct: 35 NDGFT 39
>NP_057036
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  DGFTVLS 8
          D FTVLS
Sbjct: 21 DSFTVLS 27
>XP_005250022
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  NDGFT 5
          NDGFT
Sbjct: 35 NDGFT 39
>XP_005265638
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   GFTVLSN 9
           GF VLSN
Sbjct: 891 GFLVLSN 897
>XP_005273087
          Length = 2788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 2373 NRGFSLLAN 2381
>XP_006711794
          Length = 3022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 1594 NRGFSLLAN 1602
>XP_005273086
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 2373 NRGFSLLAN 2381
>XP_005273085
          Length = 3755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 2327 NRGFSLLAN 2335
>XP_005273084
          Length = 3801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    NDGFTVLSN 9
            N GF++L+N
Sbjct: 2373 NRGFSLLAN 2381
>NP_057336
          Length = 4857

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>NP_006421
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NDGFTVL 7
          NDG T+L
Sbjct: 72 NDGATIL 78
>NP_000304
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DGFTVLSN 9
           +GF +LSN
Sbjct: 188 NGFVMLSN 195
>NP_006420
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NDGFTVL 7
          NDG T+L
Sbjct: 60 NDGATIL 66
>NP_001159757
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NDGFTVL 7
          NDG T+L
Sbjct: 16 NDGATIL 22
>NP_110379
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NDGFTVL 7
          NDG T+L
Sbjct: 56 NDGATIL 62
>XP_006723584
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NDGFTVLSN 9
           ND   VLSN
Sbjct: 626 NDSHKVLSN 634
>XP_006723583
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NDGFTVLSN 9
           ND   VLSN
Sbjct: 626 NDSHKVLSN 634
>XP_006723582
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NDGFTVLSN 9
           ND   VLSN
Sbjct: 626 NDSHKVLSN 634
>XP_005247683
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DGFTVLSN 9
           +GF +LSN
Sbjct: 220 NGFVMLSN 227
>XP_006712120
          Length = 4812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264512
          Length = 4840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264511
          Length = 4847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_006712119
          Length = 4851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264510
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_006712118
          Length = 4864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264509
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264508
          Length = 4875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_006712117
          Length = 4878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264507
          Length = 4880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_005264506
          Length = 4884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NDGFTV 6
           +DGFTV
Sbjct: 659 DDGFTV 664
>XP_006710114
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   NDGFTVLSN 9
           ND   VLSN
Sbjct: 408 NDSHKVLSN 416
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.133    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 584,046
Number of extensions: 1105
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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