Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           20     509
NP_000240                                                              20     509
NP_001161089                                                           20     509
NP_005352                                                              16    5631
NP_705692                                                              16    5631
NP_786884                                                              16    5631
NP_001269431                                                           16    5631
NP_001269434                                                           16    5631
NP_786885                                                              16    5631
NP_001269433                                                           16    5631
NP_001269430                                                           16    5631
XP_006724877                                                           16    5631
XP_005277896                                                           16    5631
XP_005277895                                                           16    5631
XP_005277893                                                           16    5631
NP_001165783                                                           15    9605
NP_002661                                                              15    9605
NP_001138791                                                           15    9605
XP_006713725                                                           15    9605
XP_006713724                                                           15    9605
XP_006713723                                                           15    9605
XP_005270768                                                           15    9605
NP_036448                                                              15    9605
>NP_001245200
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAVSREMIE 9
           NAVSRE+IE
Sbjct: 222 NAVSRELIE 230
>NP_000240
          Length = 756

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAVSREMIE 9
           NAVSRE+IE
Sbjct: 222 NAVSRELIE 230
>NP_001161089
          Length = 658

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAVSREMIE 9
           NAVSRE+IE
Sbjct: 124 NAVSRELIE 132
>NP_005352
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_705692
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_786884
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_001269431
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_001269434
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_786885
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_001269433
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_001269430
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>XP_006724877
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>XP_005277896
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>XP_005277895
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>XP_005277893
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVSREMIE 9
           A+SR+M+E
Sbjct: 108 AISRKMVE 115
>NP_001165783
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>NP_002661
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>NP_001138791
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>XP_006713725
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>XP_006713724
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>XP_006713723
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAVSREMI 8
           NAV +EMI
Sbjct: 563 NAVRQEMI 570
>XP_005270768
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NAVSREMIE 9
           + ++REM+E
Sbjct: 109 SVITREMVE 117
>NP_036448
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NAVSREMIE 9
          + ++REM+E
Sbjct: 79 SVITREMVE 87
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.118    0.273 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 288,512
Number of extensions: 298
Number of successful extensions: 23
Number of sequences better than 10000.0: 23
Number of HSP's gapped: 23
Number of HSP's successfully gapped: 23
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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