Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           21     229
NP_036462                                                              21     229
NP_001243397                                                           21     229
XP_005269721                                                           21     229
NP_001513                                                              19     869
NP_000171                                                              18    1482
NP_001273424                                                           17    2528
NP_062546                                                              17    2528
XP_006720675                                                           17    2528
XP_006720674                                                           17    2528
XP_006720673                                                           17    2528
XP_006720672                                                           17    2528
XP_005254605                                                           17    2528
XP_005254604                                                           17    2528
NP_001138498                                                           17    4312
NP_775099                                                              17    4312
NP_056472                                                              17    4312
NP_683763                                                              17    4312
NP_036429                                                              17    4312
NP_987101                                                              17    4312
NP_987100                                                              17    4312
NP_001172046                                                           17    4312
XP_005252108                                                           17    4312
XP_005263443                                                           17    4312
XP_005263442                                                           17    4312
XP_005263441                                                           17    4312
XP_005263440                                                           17    4312
XP_005263439                                                           17    4312
NP_001116867                                                           17    4312
NP_005383                                                              17    4312
NP_071387                                                              17    4312
NP_001268666                                                           16    5631
NP_004444                                                              16    5631
NP_001268667                                                           16    5631
NP_001019626                                                           16    5631
NP_071924                                                              16    5631
NP_001647                                                              16    5631
XP_005248554                                                           16    5631
NP_000126                                                              16    7355
NP_060040                                                              16    7355
NP_000071                                                              16    7355
NP_001273096                                                           16    7355
NP_071940                                                              16    7355
XP_005256351                                                           16    7355
XP_006721231                                                           16    7355
XP_006721230                                                           16    7355
XP_005268066                                                           16    7355
NP_055106                                                              15    9605
NP_001171826                                                           15    9605
NP_055922                                                              15    9605
NP_001171825                                                           15    9605
NP_036538                                                              15    9605
NP_001171827                                                           15    9605
NP_068746                                                              15    9605
NP_001165161                                                           15    9605
NP_115622                                                              15    9605
XP_006724648                                                           15    9605
XP_005262057                                                           15    9605
XP_005262055                                                           15    9605
XP_005262056                                                           15    9605
XP_005262054                                                           15    9605
XP_005262053                                                           15    9605
XP_005261468                                                           15    9605
XP_005261467                                                           15    9605
XP_006724235                                                           15    9605
XP_005261466                                                           15    9605
XP_006719268                                                           15    9605
XP_005268650                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    NANIGLYE 8
            NANIGLYE
Sbjct: 1497 NANIGLYE 1504
>NP_036462
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    NANIGLYE 8
            NANIGLYE
Sbjct: 1789 NANIGLYE 1796
>NP_001243397
          Length = 1890

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    NANIGLYE 8
            NANIGLYE
Sbjct: 1606 NANIGLYE 1613
>XP_005269721
          Length = 2073

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    NANIGLYE 8
            NANIGLYE
Sbjct: 1789 NANIGLYE 1796
>NP_001513
          Length = 1108

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NANIGLYEG 9
           N+NI +YEG
Sbjct: 560 NSNIAIYEG 568
>NP_000171
          Length = 1103

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NIGLYEG 9
           NIG+YEG
Sbjct: 551 NIGVYEG 557
>NP_001273424
          Length = 1083

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 237 HTNIGLYE 244
>NP_062546
          Length = 1076

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 230 HTNIGLYE 237
>XP_006720675
          Length = 988

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 142 HTNIGLYE 149
>XP_006720674
          Length = 988

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 142 HTNIGLYE 149
>XP_006720673
          Length = 1013

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 230 HTNIGLYE 237
>XP_006720672
          Length = 1053

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 230 HTNIGLYE 237
>XP_005254605
          Length = 1076

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 230 HTNIGLYE 237
>XP_005254604
          Length = 1076

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           + NIGLYE
Sbjct: 230 HTNIGLYE 237
>NP_001138498
          Length = 2299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IGLYEG 9
           +GLYEG
Sbjct: 471 VGLYEG 476
>NP_775099
          Length = 2595

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NANIGLYEG 9
            N N+  YEG
Sbjct: 1363 NLNLNFYEG 1371
>NP_056472
          Length = 2277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    NANIGLYEG 9
            N N+  YEG
Sbjct: 1045 NLNLNFYEG 1053
>NP_683763
          Length = 224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IGLYEG 9
          +GLYEG
Sbjct: 44 VGLYEG 49
>NP_036429
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>NP_987101
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>NP_987100
          Length = 449

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>NP_001172046
          Length = 218

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IGLYEG 9
          +GLYEG
Sbjct: 44 VGLYEG 49
>XP_005252108
          Length = 1097

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +ANI LYE
Sbjct: 275 SANISLYE 282
>XP_005263443
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>XP_005263442
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>XP_005263441
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>XP_005263440
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>XP_005263439
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NANIGLYE 8
           NAN G YE
Sbjct: 170 NANSGYYE 177
>NP_001116867
          Length = 211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  IGLYEG 9
          +GLYEG
Sbjct: 44 VGLYEG 49
>NP_005383
          Length = 1096

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +ANI LYE
Sbjct: 275 SANISLYE 282
>NP_071387
          Length = 704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IGLYEG 9
           +GLYEG
Sbjct: 481 VGLYEG 486
>NP_001268666
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NANIGLYEG 9
           N N+ +Y+G
Sbjct: 500 NRNLSIYDG 508
>NP_004444
          Length = 617

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NANIGLYEG 9
           N N+ +Y+G
Sbjct: 547 NRNLSIYDG 555
>NP_001268667
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   NANIGLYEG 9
           N N+ +Y+G
Sbjct: 486 NRNLSIYDG 494
>NP_001019626
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NANIGLYEG 9
          NAN+GL  G
Sbjct: 29 NANLGLQLG 37
>NP_071924
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   NANIGLY 7
           N+NIG Y
Sbjct: 387 NSNIGFY 393
>NP_001647
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ANIGLYEG 9
           + +GLYEG
Sbjct: 550 SGMGLYEG 557
>XP_005248554
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ANIGLYEG 9
           + +GLYEG
Sbjct: 374 SGMGLYEG 381
>NP_000126
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NIGLYE 8
           N+GLYE
Sbjct: 527 NMGLYE 532
>NP_060040
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    NANIGLYE 8
            NA++G YE
Sbjct: 1111 NAHMGYYE 1118
>NP_000071
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NANIGLYEG 9
           +AN+ +YEG
Sbjct: 125 DANVLVYEG 133
>NP_001273096
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NIGLYE 8
           N+GLYE
Sbjct: 527 NMGLYE 532
>NP_071940
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NANIGLYEG 9
           ++N+G+Y G
Sbjct: 852 DSNMGIYTG 860
>XP_005256351
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NIGLYE 8
           N+GLYE
Sbjct: 527 NMGLYE 532
>XP_006721231
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NIGLYE 8
           N+GLYE
Sbjct: 186 NMGLYE 191
>XP_006721230
          Length = 1412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NIGLYE 8
           N+GLYE
Sbjct: 527 NMGLYE 532
>XP_005268066
          Length = 1172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    NANIGLYEG 9
            ++N+G+Y G
Sbjct: 1086 DSNMGIYTG 1094
>NP_055106
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 136 DANAGLFE 143
>NP_001171826
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>NP_055922
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>NP_001171825
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 309 NANLTLFE 316
>NP_036538
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NANIGLYEG 9
           N N+GL  G
Sbjct: 153 NGNVGLEPG 161
>NP_001171827
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>NP_068746
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ANIGLYEG 9
           AN+ L++G
Sbjct: 271 ANVALFDG 278
>NP_001165161
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 162 DANAGLFE 169
>NP_115622
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NANIGL 6
           NAN+GL
Sbjct: 421 NANLGL 426
>XP_006724648
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 309 NANLTLFE 316
>XP_005262057
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 309 NANLTLFE 316
>XP_005262055
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>XP_005262056
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>XP_005262054
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 273 NANLTLFE 280
>XP_005262053
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           NAN+ L+E
Sbjct: 309 NANLTLFE 316
>XP_005261468
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 136 DANAGLFE 143
>XP_005261467
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 162 DANAGLFE 169
>XP_006724235
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 162 DANAGLFE 169
>XP_005261466
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NANIGLYE 8
           +AN GL+E
Sbjct: 162 DANAGLFE 169
>XP_006719268
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NANIGLYEG 9
           N N+GL  G
Sbjct: 153 NGNVGLEPG 161
>XP_005268650
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   NANIGLYEG 9
           N N+GL  G
Sbjct: 153 NGNVGLEPG 161
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.141    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 544,278
Number of extensions: 952
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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