Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              20     299
NP_444254                                                              20     299
NP_444253                                                              20     299
NP_444255                                                              20     299
XP_005247551                                                           20     299
XP_005247550                                                           20     299
XP_006713712                                                           20     299
XP_005247549                                                           20     299
NP_001278327                                                           18    1935
NP_001005751                                                           18    1935
XP_005269865                                                           18    1935
XP_006717894                                                           18    1935
XP_005269864                                                           18    1935
NP_001162577                                                           18    1935
NP_056077                                                              18    1935
NP_006436                                                              17    4312
NP_001124456                                                           16    5631
NP_001124448                                                           16    5631
NP_003485                                                              16    5631
NP_001123927                                                           16    5631
NP_001124454                                                           16    5631
NP_001124452                                                           16    5631
NP_001124459                                                           16    5631
NP_001124455                                                           16    5631
NP_001124457                                                           16    5631
NP_001124450                                                           16    5631
NP_001124451                                                           16    5631
NP_001124449                                                           16    5631
NP_001124458                                                           16    5631
NP_001124453                                                           16    5631
NP_689916                                                              16    5631
XP_006726453                                                           16    5631
XP_006715953                                                           16    5631
XP_006715952                                                           16    5631
XP_005250250                                                           16    5631
XP_006715951                                                           16    5631
XP_005250248                                                           16    5631
XP_006712226                                                           16    5631
XP_005264642                                                           16    5631
XP_005264641                                                           16    5631
XP_006711783                                                           16    5631
NP_056981                                                              16    5631
NP_001166176                                                           16    7355
NP_037506                                                              16    7355
NP_001036024                                                           16    7355
NP_001409                                                              16    7355
NP_003608                                                              16    7355
NP_001155901                                                           16    7355
NP_001241678                                                           16    7355
NP_059110                                                              15    9605
NP_001070731                                                           15    9605
NP_001798                                                              15    9605
NP_004993                                                              15    9605
NP_001162578                                                           15    9605
NP_001193719                                                           15    9605
NP_001231924                                                           15    9605
NP_001193718                                                           15    9605
XP_006726896                                                           15    9605
XP_006724470                                                           15    9605
XP_006724137                                                           15    9605
XP_006710179                                                           15    9605
>NP_444256
          Length = 1794

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 959 NAKPAETLK 967

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 971 NAKPAETLK 979
>NP_444254
          Length = 1845

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 959 NAKPAETLK 967

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 971 NAKPAETLK 979
>NP_444253
          Length = 1914

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1028 NAKPAETLK 1036

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1040 NAKPAETLK 1048
>NP_444255
          Length = 1863

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1028 NAKPAETLK 1036

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1040 NAKPAETLK 1048
>XP_005247551
          Length = 1855

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 969 NAKPAETLK 977

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   NAKPAKTLK 9
           NAKPA+TLK
Sbjct: 981 NAKPAETLK 989
>XP_005247550
          Length = 1856

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1038 NAKPAETLK 1046

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1050 NAKPAETLK 1058
>XP_006713712
          Length = 1923

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1038 NAKPAETLK 1046

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1050 NAKPAETLK 1058
>XP_005247549
          Length = 1924

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1038 NAKPAETLK 1046

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    NAKPAKTLK 9
            NAKPA+TLK
Sbjct: 1050 NAKPAETLK 1058
>NP_001278327
          Length = 1320

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 317 AKPRKTLK 324
>NP_001005751
          Length = 1341

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 317 AKPRKTLK 324
>XP_005269865
          Length = 1331

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 369 AKPRKTLK 376
>XP_006717894
          Length = 1342

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 369 AKPRKTLK 376
>XP_005269864
          Length = 1364

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 369 AKPRKTLK 376
>NP_001162577
          Length = 1279

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 317 AKPRKTLK 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP+KT K
Sbjct: 467 HSKPSKTRK 475
>NP_056077
          Length = 1320

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKPAKTLK 9
           AKP KTLK
Sbjct: 317 AKPRKTLK 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP+KT K
Sbjct: 467 HSKPSKTRK 475
>NP_006436
          Length = 2335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   NAKPAKTL 8
           N KP KTL
Sbjct: 523 NLKPVKTL 530
>NP_001124456
          Length = 2088

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1942 KPAKTAK 1948
>NP_001124448
          Length = 2066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1920 KPAKTAK 1926
>NP_003485
          Length = 2080

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1934 KPAKTAK 1940
>NP_001123927
          Length = 2081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1935 KPAKTAK 1941
>NP_001124454
          Length = 2112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1966 KPAKTAK 1972
>NP_001124452
          Length = 2097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1951 KPAKTAK 1957
>NP_001124459
          Length = 2119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1973 KPAKTAK 1979
>NP_001124455
          Length = 2102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1956 KPAKTAK 1962
>NP_001124457
          Length = 2098

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1952 KPAKTAK 1958
>NP_001124450
          Length = 2101

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1955 KPAKTAK 1961
>NP_001124451
          Length = 2111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1965 KPAKTAK 1971
>NP_001124449
          Length = 2087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1941 KPAKTAK 1947
>NP_001124458
          Length = 2067

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1921 KPAKTAK 1927
>NP_001124453
          Length = 2118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1972 KPAKTAK 1978
>NP_689916
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_006726453
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AKPAKT 7
           AKPAKT
Sbjct: 252 AKPAKT 257
>XP_006715953
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_006715952
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_005250250
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_006715951
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_005250248
          Length = 1584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  NAKPAKT 7
          N+KP+KT
Sbjct: 92 NSKPSKT 98
>XP_006712226
          Length = 590

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AKPAKT 7
           AKPAKT
Sbjct: 96  AKPAKT 101

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AKPAKT 7
           AKPAKT
Sbjct: 223 AKPAKT 228
>XP_005264642
          Length = 2132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1986 KPAKTAK 1992
>XP_005264641
          Length = 2133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KPAKTLK 9
            KPAKT K
Sbjct: 1987 KPAKTAK 1993
>XP_006711783
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AKPAKT 7
           AKPAKT
Sbjct: 289 AKPAKT 294
>NP_056981
          Length = 510

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PAKTLK 9
           PAKTLK
Sbjct: 123 PAKTLK 128
>NP_001166176
          Length = 907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KPAKTLK 9
           KPAKT K
Sbjct: 529 KPAKTSK 535
>NP_037506
          Length = 868

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           +A PAKT++
Sbjct: 536 SANPAKTMQ 544
>NP_001036024
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KPAKTLK 9
           KPAKT K
Sbjct: 491 KPAKTSK 497
>NP_001409
          Length = 907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KPAKTLK 9
           KPAKT K
Sbjct: 529 KPAKTSK 535
>NP_003608
          Length = 181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KPAKTLK 9
          KPAKT K
Sbjct: 46 KPAKTQK 52
>NP_001155901
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           +A PAKT++
Sbjct: 541 SANPAKTMQ 549
>NP_001241678
          Length = 185

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KPAKTLK 9
          KPAKT K
Sbjct: 46 KPAKTQK 52
>NP_059110
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP KTL+
Sbjct: 202 DSKPLKTLE 210
>NP_001070731
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NAKPAKT 7
          NA PA+T
Sbjct: 8  NASPART 14
>NP_001798
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   NAKPAKT 7
           NAK AKT
Sbjct: 430 NAKSAKT 436
>NP_004993
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NAKPAKTL 8
           + KPAKT+
Sbjct: 368 DVKPAKTV 375
>NP_001162578
          Length = 1245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP+KT K
Sbjct: 443 HSKPSKTRK 451
>NP_001193719
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NAKPAKT 7
          NA PA+T
Sbjct: 8  NASPART 14
>NP_001231924
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NAKPAKT 7
          NA PA+T
Sbjct: 8  NASPART 14
>NP_001193718
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  NAKPAKT 7
          NA PA+T
Sbjct: 8  NASPART 14
>XP_006726896
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP KTL+
Sbjct: 217 DSKPLKTLE 225
>XP_006724470
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP KTL+
Sbjct: 188 DSKPLKTLE 196
>XP_006724137
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP KTL+
Sbjct: 128 DSKPLKTLE 136
>XP_006710179
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAKPAKTLK 9
           ++KP KTL+
Sbjct: 188 DSKPLKTLE 196
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.113    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 720,504
Number of extensions: 893
Number of successful extensions: 72
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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