Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           18    1482
NP_055903                                                              18    1482
NP_004432                                                              18    1482
NP_005949                                                              18    1482
NP_004215                                                              17    3301
XP_005274829                                                           17    3301
NP_002746                                                              17    4312
NP_059115                                                              17    4312
XP_005254598                                                           17    4312
XP_006720671                                                           17    4312
NP_005950                                                              16    5631
NP_612567                                                              16    5631
NP_003257                                                              16    5631
NP_612564                                                              16    5631
NP_067018                                                              16    5631
NP_008915                                                              16    5631
NP_001153572                                                           16    5631
NP_955360                                                              16    5631
NP_878268                                                              16    5631
NP_001193987                                                           16    7355
NP_004434                                                              16    7355
XP_006723678                                                           16    7355
XP_006720771                                                           16    7355
NP_003236                                                              16    7355
NP_001092007                                                           15    9605
NP_689499                                                              15    9605
NP_001161743                                                           15    9605
NP_694547                                                              15    9605
NP_079146                                                              15    9605
NP_001167621                                                           15    9605
NP_003382                                                              15    9605
NP_878899                                                              15    9605
NP_055532                                                              15    9605
NP_001185739                                                           15    9605
NP_001273142                                                           15    9605
NP_001273141                                                           15    9605
NP_115632                                                              15    9605
NP_003618                                                              15    9605
NP_060688                                                              15    9605
NP_001631                                                              15    9605
XP_006723575                                                           15    9605
XP_005259502                                                           15    9605
XP_005274415                                                           15    9605
XP_005274414                                                           15    9605
XP_005266139                                                           15    9605
XP_005266136                                                           15    9605
XP_006717167                                                           15    9605
XP_006717166                                                           15    9605
XP_006717165                                                           15    9605
XP_006716172                                                           15    9605
XP_006713597                                                           15    9605
XP_006713596                                                           15    9605
XP_006713595                                                           15    9605
XP_006713594                                                           15    9605
XP_005247222                                                           15    9605
XP_005265155                                                           15    9605
XP_005265154                                                           15    9605
XP_005246148                                                           15    9605
XP_005246145                                                           15    9605
XP_006712675                                                           15    9605
NP_001012780                                                           15    9605
NP_001012777                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           NAGV FVVS
Sbjct: 352 NAGVNFVVS 360
>NP_055903
          Length = 1723

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           NAGV FVVS
Sbjct: 352 NAGVNFVVS 360
>NP_004432
          Length = 984

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AGV+FVVS
Sbjct: 548 AGVVFVVS 555
>NP_005949
          Length = 350

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  NAGVIFVVS 9
          NAG IFVVS
Sbjct: 60 NAGNIFVVS 68
>NP_004215
          Length = 617

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  NAGVIFVVS 9
          N+G IFVVS
Sbjct: 61 NSGNIFVVS 69
>XP_005274829
          Length = 241

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  NAGVIFVVS 9
          N+G IFVVS
Sbjct: 61 NSGNIFVVS 69
>NP_002746
          Length = 393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NAGVIFVVS 9
          N GV+F VS
Sbjct: 78 NGGVVFKVS 86
>NP_059115
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   NAGVIFVV 8
           +AG+IFV+
Sbjct: 250 DAGIIFVI 257
>XP_005254598
          Length = 284

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NAGVIFVVS 9
          N GV+F VS
Sbjct: 78 NGGVVFKVS 86
>XP_006720671
          Length = 367

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  NAGVIFVVS 9
          N GV+F VS
Sbjct: 78 NGGVVFKVS 86
>NP_005950
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  NAGVIFVVS 9
          NAG +F+VS
Sbjct: 73 NAGNLFLVS 81
>NP_612567
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AGVIFVV 8
           AG+IF+V
Sbjct: 564 AGIIFIV 570
>NP_003257
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AGVIFVV 8
           AG+IF+V
Sbjct: 724 AGIIFIV 730
>NP_612564
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AGVIFVV 8
           AG+IF+V
Sbjct: 764 AGIIFIV 770
>NP_067018
          Length = 220

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           +G++FV+S
Sbjct: 121 SGIVFVIS 128
>NP_008915
          Length = 228

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++F++S
Sbjct: 120 AGIVFILS 127
>NP_001153572
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++F++S
Sbjct: 99  AGIVFILS 106
>NP_955360
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG+IF+++
Sbjct: 122 AGIIFIIT 129
>NP_878268
          Length = 226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++F++S
Sbjct: 118 AGIVFILS 125
>NP_001193987
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  NAGVIFVV 8
          N G+IF++
Sbjct: 26 NTGIIFIM 33
>NP_004434
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++FVV+
Sbjct: 566 AGLVFVVA 573
>XP_006723678
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +AG+IFV S
Sbjct: 184 DAGIIFVGS 192
>XP_006720771
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  NAGVIFVV 8
          N G+IF++
Sbjct: 26 NTGIIFIM 33
>NP_003236
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +AG+IFV S
Sbjct: 159 DAGIIFVGS 167
>NP_001092007
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 518 DASILFVVS 526
>NP_689499
          Length = 1317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 493 DASILFVVS 501
>NP_001161743
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++FVV+
Sbjct: 267 AGLLFVVT 274
>NP_694547
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++FVV+
Sbjct: 271 AGLLFVVT 278
>NP_079146
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    NAGVIF 6
            NAGV+F
Sbjct: 1313 NAGVLF 1318
>NP_001167621
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 91 GVIFVV 96
>NP_003382
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +AGV+F ++
Sbjct: 116 SAGVVFAIT 124
>NP_878899
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 91 GVIFVV 96
>NP_055532
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NAGVIF 6
           NAGV+F
Sbjct: 554 NAGVLF 559
>NP_001185739
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           +AGV FVV
Sbjct: 190 DAGVAFVV 197
>NP_001273142
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           N G+IF+V
Sbjct: 160 NYGIIFLV 167
>NP_001273141
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           N G+IF+V
Sbjct: 200 NYGIIFLV 207
>NP_115632
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           N G+IF+V
Sbjct: 304 NYGIIFLV 311
>NP_003618
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           +AGV FVV
Sbjct: 190 DAGVAFVV 197
>NP_060688
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AGVIFVVS 9
           AGVIF+ S
Sbjct: 696 AGVIFINS 703
>NP_001631
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NAGVIFV 7
           +AGV+FV
Sbjct: 255 DAGVVFV 261
>XP_006723575
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NAGVIF 6
           NAGV+F
Sbjct: 554 NAGVLF 559
>XP_005259502
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   NAGVIF 6
           NAGV+F
Sbjct: 567 NAGVLF 572
>XP_005274415
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           +AGV FVV
Sbjct: 206 DAGVAFVV 213
>XP_005274414
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   NAGVIFVV 8
           +AGV FVV
Sbjct: 216 DAGVAFVV 223
>XP_005266139
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 519 DASILFVVS 527
>XP_005266136
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 519 DASILFVVS 527
>XP_006717167
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 485 DASILFVVS 493
>XP_006717166
          Length = 1316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 492 DASILFVVS 500
>XP_006717165
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   NAGVIFVVS 9
           +A ++FVVS
Sbjct: 519 DASILFVVS 527
>XP_006716172
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  NAGVIFVVS 9
          +AGV+F ++
Sbjct: 87 SAGVVFAIT 95
>XP_006713597
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 66 GVIFVV 71
>XP_006713596
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 66 GVIFVV 71
>XP_006713595
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 76 GVIFVV 81
>XP_006713594
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GVIFVV 8
          GVIFVV
Sbjct: 76 GVIFVV 81
>XP_005247222
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AGVIFVVS 9
           AG++FVV+
Sbjct: 271 AGLLFVVT 278
>XP_005265155
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NAGVIFV 7
           +AGV+FV
Sbjct: 154 DAGVVFV 160
>XP_005265154
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   NAGVIFV 7
           +AGV+FV
Sbjct: 209 DAGVVFV 215
>XP_005246148
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AGVIFVVS 9
           AGVIF+ S
Sbjct: 557 AGVIFINS 564
>XP_005246145
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AGVIFVVS 9
           AGVIF+ S
Sbjct: 685 AGVIFINS 692
>XP_006712675
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AGVIFVVS 9
           AGVIF+ S
Sbjct: 697 AGVIFINS 704
>NP_001012780
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AGVIFV 7
           AGVIFV
Sbjct: 108 AGVIFV 113
>NP_001012777
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AGVIFV 7
           AGVIFV
Sbjct: 108 AGVIFV 113
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.143    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,117
Number of extensions: 932
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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