Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     390
NP_065915                                                              18    1935
XP_005246765                                                           18    1935
NP_001005207                                                           17    2528
NP_056109                                                              17    2528
XP_005257447                                                           17    2528
XP_005257446                                                           17    2528
XP_005257445                                                           17    2528
XP_005257444                                                           17    2528
XP_005257443                                                           17    2528
XP_005257442                                                           17    2528
NP_061939                                                              17    3301
NP_056377                                                              17    4312
NP_803879                                                              16    5631
NP_803881                                                              16    5631
NP_001258992                                                           16    5631
NP_110428                                                              16    5631
NP_001229291                                                           16    5631
NP_001258991                                                           16    5631
NP_001092270                                                           16    5631
NP_001258990                                                           16    5631
NP_940931                                                              16    5631
NP_001138525                                                           16    5631
NP_001164056                                                           16    5631
NP_694566                                                              16    5631
XP_006724671                                                           16    5631
XP_006724670                                                           16    5631
XP_006721944                                                           16    5631
XP_006721943                                                           16    5631
XP_006721942                                                           16    5631
NP_055448                                                              16    5631
NP_078911                                                              16    7355
NP_115979                                                              16    7355
NP_073592                                                              16    7355
NP_660281                                                              16    7355
NP_542397                                                              16    7355
NP_001008726                                                           16    7355
NP_001005366                                                           16    7355
NP_001245201                                                           16    7355
XP_005254013                                                           16    7355
XP_005254012                                                           16    7355
XP_005254011                                                           16    7355
XP_006717298                                                           16    7355
XP_005252185                                                           16    7355
XP_006717294                                                           16    7355
XP_005252184                                                           16    7355
XP_005252183                                                           16    7355
XP_006710939                                                           16    7355
XP_005271228                                                           16    7355
XP_006710938                                                           16    7355
XP_006710937                                                           16    7355
NP_057043                                                              15    9605
NP_477352                                                              15    9605
NP_002641                                                              15    9605
NP_001137484                                                           15    9605
XP_005261692                                                           15    9605
XP_005261691                                                           15    9605
XP_005274106                                                           15    9605
XP_005274105                                                           15    9605
XP_006716779                                                           15    9605
NP_004138                                                              15    9605
NP_000929                                                              15    9605
NP_056969                                                              15    9605
>NP_005179
          Length = 906

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MVKNILREF 9
           M KNILREF
Sbjct: 887 MAKNILREF 895
>NP_065915
          Length = 653

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVKNILREF 9
           MV NILR+F
Sbjct: 248 MVGNILRDF 256
>XP_005246765
          Length = 653

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVKNILREF 9
           MV NILR+F
Sbjct: 248 MVGNILRDF 256
>NP_001005207
          Length = 964

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>NP_056109
          Length = 964

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>XP_005257447
          Length = 925

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>XP_005257446
          Length = 925

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>XP_005257445
          Length = 930

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>XP_005257444
          Length = 930

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 323 KNIIREF 329
>XP_005257443
          Length = 939

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 323 KNIIREF 329
>XP_005257442
          Length = 973

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KNI+REF
Sbjct: 357 KNIIREF 363
>NP_061939
          Length = 1249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    MVKNILREF 9
            MVK ILRE+
Sbjct: 1046 MVKVILREY 1054
>NP_056377
          Length = 489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKNI+RE
Sbjct: 193 VKNIIRE 199
>NP_803879
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_803881
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_001258992
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_110428
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_001229291
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_001258991
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_001092270
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_001258990
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>NP_940931
          Length = 1503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           +++N+L+EF
Sbjct: 308 VIQNVLQEF 316
>NP_001138525
          Length = 856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           +++N+L+EF
Sbjct: 252 VIQNVLQEF 260
>NP_001164056
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NILREF 9
           NILREF
Sbjct: 453 NILREF 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NILREF 9
           NILREF
Sbjct: 778 NILREF 783
>NP_694566
          Length = 1458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NILREF 9
           NILREF
Sbjct: 442 NILREF 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   NILREF 9
           NILREF
Sbjct: 789 NILREF 794
>XP_006724671
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>XP_006724670
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           M+K+++RE+
Sbjct: 439 MLKDVIREY 447
>XP_006721944
          Length = 1232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           +++N+L+EF
Sbjct: 308 VIQNVLQEF 316
>XP_006721943
          Length = 1456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           +++N+L+EF
Sbjct: 308 VIQNVLQEF 316
>XP_006721942
          Length = 1503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MVKNILREF 9
           +++N+L+EF
Sbjct: 308 VIQNVLQEF 316
>NP_055448
          Length = 1173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MVKNILRE 8
           + KNILRE
Sbjct: 519 LYKNILRE 526
>NP_078911
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MVKNILREF 9
           MVK+ LR F
Sbjct: 391 MVKDALRSF 399
>NP_115979
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKN+L+E
Sbjct: 548 VKNVLKE 554
>NP_073592
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KNILREF 9
          KN+++EF
Sbjct: 60 KNVMKEF 66
>NP_660281
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKNILREF 9
           VKN+LR +
Sbjct: 380 VKNLLRNY 387
>NP_542397
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NILREF 9
          N+LREF
Sbjct: 61 NVLREF 66
>NP_001008726
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NILREF 9
          N+LREF
Sbjct: 61 NVLREF 66
>NP_001005366
          Length = 1265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKN+L+E
Sbjct: 517 VKNVLKE 523
>NP_001245201
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  NILREF 9
          N+LREF
Sbjct: 61 NVLREF 66
>XP_005254013
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKN+L+E
Sbjct: 511 VKNVLKE 517
>XP_005254012
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKN+L+E
Sbjct: 517 VKNVLKE 523
>XP_005254011
          Length = 1334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           VKN+L+E
Sbjct: 548 VKNVLKE 554
>XP_006717298
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KNILREF 9
          KN+++EF
Sbjct: 60 KNVMKEF 66
>XP_005252185
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MVKNILREF 9
           MVK+ LR F
Sbjct: 235 MVKDALRSF 243
>XP_006717294
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MVKNILREF 9
           MVK+ LR F
Sbjct: 391 MVKDALRSF 399
>XP_005252184
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MVKNILREF 9
           MVK+ LR F
Sbjct: 391 MVKDALRSF 399
>XP_005252183
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MVKNILREF 9
           MVK+ LR F
Sbjct: 391 MVKDALRSF 399
>XP_006710939
          Length = 989

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKNILREF 9
           VKN+LR +
Sbjct: 326 VKNLLRNY 333
>XP_005271228
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKNILREF 9
           VKN+LR +
Sbjct: 380 VKNLLRNY 387
>XP_006710938
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKNILREF 9
           VKN+LR +
Sbjct: 380 VKNLLRNY 387
>XP_006710937
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VKNILREF 9
           VKN+LR +
Sbjct: 380 VKNLLRNY 387
>NP_057043
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           +N++REF
Sbjct: 249 ENVIREF 255
>NP_477352
          Length = 2102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    VKNILRE 8
            ++N+LRE
Sbjct: 1370 IRNVLRE 1376
>NP_002641
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   VKNILRE 8
           ++N+LRE
Sbjct: 122 IRNVLRE 128
>NP_001137484
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           +N++REF
Sbjct: 211 ENVIREF 217
>XP_005261692
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    VKNILRE 8
            ++N+LRE
Sbjct: 1398 IRNVLRE 1404
>XP_005261691
          Length = 2099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    VKNILRE 8
            ++N+LRE
Sbjct: 1367 IRNVLRE 1373
>XP_005274106
          Length = 1685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKNILREF 9
          +VKN+ RE+
Sbjct: 80 IVKNVGREY 88
>XP_005274105
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKNILREF 9
          +VKN+ RE+
Sbjct: 80 IVKNVGREY 88
>XP_006716779
          Length = 2399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    KNILRE 8
            KN+LRE
Sbjct: 1156 KNVLRE 1161
>NP_004138
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KNILREF 9
           KN+++EF
Sbjct: 327 KNLIKEF 333
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MVKNILRE 8
           M KN+L+E
Sbjct: 407 MFKNLLKE 414
>NP_056969
          Length = 1555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MVKNILREF 9
          +VKN+ RE+
Sbjct: 80 IVKNVGREY 88
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.150    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 447,229
Number of extensions: 743
Number of successful extensions: 65
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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