Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              19     869
NP_003310                                                              17    4312
NP_597676                                                              17    4312
NP_001243779                                                           17    4312
NP_596869                                                              17    4312
XP_005246888                                                           17    4312
XP_006712788                                                           17    4312
XP_006712787                                                           17    4312
XP_006712786                                                           17    4312
NP_001254479                                                           17    4312
NP_597681                                                              17    4312
NP_055426                                                              16    5631
XP_006715467                                                           16    5631
NP_001135446                                                           16    7355
NP_071372                                                              16    7355
NP_001135445                                                           16    7355
NP_056069                                                              16    7355
XP_006716380                                                           16    7355
XP_006716379                                                           16    7355
XP_005273516                                                           16    7355
XP_005273515                                                           16    7355
XP_005248822                                                           16    7355
XP_005245872                                                           16    7355
XP_005245870                                                           16    7355
XP_006710576                                                           16    7355
XP_005245869                                                           16    7355
XP_006710575                                                           16    7355
XP_005245868                                                           16    7355
XP_005245867                                                           16    7355
XP_005245866                                                           16    7355
NP_078852                                                              16    7355
NP_005912                                                              15    9605
NP_001123308                                                           15    9605
NP_001123306                                                           15    9605
NP_001123312                                                           15    9605
NP_001123307                                                           15    9605
NP_001123316                                                           15    9605
NP_001123304                                                           15    9605
NP_001123305                                                           15    9605
NP_001123309                                                           15    9605
NP_001123299                                                           15    9605
NP_001123313                                                           15    9605
NP_000710                                                              15    9605
NP_001123314                                                           15    9605
NP_001123311                                                           15    9605
NP_001123310                                                           15    9605
NP_001123318                                                           15    9605
NP_001123301                                                           15    9605
NP_001123303                                                           15    9605
NP_001123315                                                           15    9605
NP_001123302                                                           15    9605
NP_001161095                                                           15    9605
NP_955630                                                              15    9605
NP_001161096                                                           15    9605
NP_001161097                                                           15    9605
NP_116202                                                              15    9605
NP_998771                                                              15    9605
NP_001073137                                                           15    9605
NP_001273382                                                           15    9605
XP_006720018                                                           15    9605
XP_005254139                                                           15    9605
XP_006720017                                                           15    9605
XP_006719080                                                           15    9605
XP_006719079                                                           15    9605
XP_006719078                                                           15    9605
XP_005248577                                                           15    9605
XP_005248576                                                           15    9605
NP_803875                                                              15    9605
>NP_004251
          Length = 1208

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVKLVDS G
Sbjct: 989 MVKLVDSMG 997
>NP_003310
          Length = 26926

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 22637 MVKVLDSPG 22645
>NP_597676
          Length = 27051

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 22762 MVKVLDSPG 22770
>NP_001243779
          Length = 34350

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 30061 MVKVLDSPG 30069
>NP_596869
          Length = 33423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 29134 MVKVLDSPG 29142
>XP_005246888
          Length = 22663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 18374 MVKVLDSPG 18382
>XP_006712788
          Length = 24022

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 19733 MVKVLDSPG 19741
>XP_006712787
          Length = 33978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 29689 MVKVLDSPG 29697
>XP_006712786
          Length = 35484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 31195 MVKVLDSPG 31203
>NP_001254479
          Length = 35991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 31702 MVKVLDSPG 31710
>NP_597681
          Length = 27118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     MVKLVDSTG 9
             MVK++DS G
Sbjct: 22829 MVKVLDSPG 22837
>NP_055426
          Length = 5596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLVDSTG 9
           KLVD TG
Sbjct: 951 KLVDGTG 957
>XP_006715467
          Length = 5550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLVDSTG 9
           KLVD TG
Sbjct: 951 KLVDGTG 957
>NP_001135446
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 570 LKMVESTG 577
>NP_071372
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 575 LKMVESTG 582
>NP_001135445
          Length = 1175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 570 LKMVESTG 577
>NP_056069
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVK++ +TG
Sbjct: 871 MVKILQATG 879
>XP_006716380
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVK++ +TG
Sbjct: 807 MVKILQATG 815
>XP_006716379
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVK++ +TG
Sbjct: 807 MVKILQATG 815
>XP_005273516
          Length = 1762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVK++ +TG
Sbjct: 807 MVKILQATG 815
>XP_005273515
          Length = 1805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           MVK++ +TG
Sbjct: 871 MVKILQATG 879
>XP_005248822
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VKLVDSTG 9
           +KL D TG
Sbjct: 208 IKLTDKTG 215
>XP_005245872
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 575 LKMVESTG 582
>XP_005245870
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 575 LKMVESTG 582
>XP_006710576
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 561 LKMVESTG 568
>XP_005245869
          Length = 1193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 566 LKMVESTG 573
>XP_006710575
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 569 LKMVESTG 576
>XP_005245868
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 570 LKMVESTG 577
>XP_005245867
          Length = 1201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 574 LKMVESTG 581
>XP_005245866
          Length = 1202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VKLVDSTG 9
           +K+V+STG
Sbjct: 575 LKMVESTG 582
>NP_078852
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VKLVDSTG 9
           +KL D TG
Sbjct: 207 IKLTDKTG 214
>NP_005912
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVDSTG 9
            L+DSTG
Sbjct: 1376 LIDSTG 1381
>NP_001123308
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1764 KLVDST 1769
>NP_001123306
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1766 KLVDST 1771
>NP_001123312
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001123307
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1766 KLVDST 1771
>NP_001123316
          Length = 2135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1744 KLVDST 1749
>NP_001123304
          Length = 2158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1767 KLVDST 1772
>NP_001123305
          Length = 2157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1766 KLVDST 1771
>NP_001123309
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1755 KLVDST 1760
>NP_001123299
          Length = 2186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1795 KLVDST 1800
>NP_001123313
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_000710
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001123314
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001123311
          Length = 2144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1753 KLVDST 1758
>NP_001123310
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1755 KLVDST 1760
>NP_001123318
          Length = 2127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1736 KLVDST 1741
>NP_001123301
          Length = 2179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1788 KLVDST 1793
>NP_001123303
          Length = 2166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1775 KLVDST 1780
>NP_001123315
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001123302
          Length = 2173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001161095
          Length = 2138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_955630
          Length = 2221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1795 KLVDST 1800
>NP_001161096
          Length = 2173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1747 KLVDST 1752
>NP_001161097
          Length = 2198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1736 KLVDST 1741
>NP_116202
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 643 MIILLDNTG 651
>NP_998771
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KLVDSTG 9
           +LVD+TG
Sbjct: 431 RLVDTTG 437
>NP_001073137
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 624 MIILLDNTG 632
>NP_001273382
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 513 MIILLDNTG 521
>XP_006720018
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 397 MIILLDNTG 405
>XP_005254139
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 407 MIILLDNTG 415
>XP_006720017
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MVKLVDSTG 9
           M+ L+D+TG
Sbjct: 624 MIILLDNTG 632
>XP_006719080
          Length = 2168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1777 KLVDST 1782
>XP_006719079
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1068 KLVDST 1073
>XP_006719078
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    KLVDST 8
            KLVDST
Sbjct: 1514 KLVDST 1519
>XP_005248577
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVDSTG 9
            L+DSTG
Sbjct: 1213 LIDSTG 1218
>XP_005248576
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LVDSTG 9
            L+DSTG
Sbjct: 1239 LIDSTG 1244
>NP_803875
          Length = 4243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VKLVDST 8
            +KLVD+T
Sbjct: 3646 IKLVDTT 3652
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.130    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 436,099
Number of extensions: 782
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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