Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_057302                                                              17    2528
XP_005248593                                                           17    2528
XP_006714714                                                           17    2528
XP_006714713                                                           17    2528
XP_005248591                                                           17    2528
NP_009117                                                              16    5631
NP_079229                                                              16    5631
XP_005260321                                                           16    5631
XP_005260320                                                           16    5631
XP_006723758                                                           16    5631
XP_006723757                                                           16    5631
XP_006723756                                                           16    5631
XP_006723755                                                           16    5631
XP_006723754                                                           16    5631
XP_006723753                                                           16    5631
XP_005260319                                                           16    5631
XP_005253995                                                           16    5631
XP_006719669                                                           16    5631
NP_005049                                                              16    7355
NP_005237                                                              16    7355
NP_001006121                                                           16    7355
NP_689798                                                              16    7355
NP_001006118                                                           16    7355
NP_775899                                                              16    7355
XP_005262647                                                           16    7355
XP_005262646                                                           16    7355
XP_005262645                                                           16    7355
XP_005262644                                                           16    7355
XP_005262643                                                           16    7355
XP_005262642                                                           16    7355
XP_005262641                                                           16    7355
XP_005262640                                                           16    7355
XP_005262634                                                           16    7355
XP_005262633                                                           16    7355
XP_005262632                                                           16    7355
XP_005262631                                                           16    7355
XP_005262574                                                           16    7355
XP_005262573                                                           16    7355
XP_005262572                                                           16    7355
XP_005262571                                                           16    7355
XP_005262570                                                           16    7355
XP_005262569                                                           16    7355
XP_005262568                                                           16    7355
XP_005271980                                                           16    7355
XP_006714636                                                           16    7355
XP_006714635                                                           16    7355
NP_001006117                                                           16    7355
NP_001006120                                                           16    7355
NP_001269                                                              15    9605
NP_872302                                                              15    9605
NP_958357                                                              15    9605
NP_001020279                                                           15    9605
NP_002080                                                              15    9605
NP_002276                                                              15    9605
XP_006719292                                                           15    9605
XP_005264002                                                           15    9605
XP_005264000                                                           15    9605
XP_006712586                                                           15    9605
XP_005263999                                                           15    9605
XP_005271318                                                           15    9605
XP_005271317                                                           15    9605
XP_005271314                                                           15    9605
NP_777592                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MVEKMLKAL 9
            +VEKMLKAL
Sbjct: 3446 VVEKMLKAL 3454
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MVEKMLKAL 9
            +VEKMLKAL
Sbjct: 3446 VVEKMLKAL 3454
>NP_057302
          Length = 870

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           + EKMLKAL
Sbjct: 360 VTEKMLKAL 368
>XP_005248593
          Length = 503

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           + EKMLKAL
Sbjct: 374 VTEKMLKAL 382
>XP_006714714
          Length = 794

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           + EKMLKAL
Sbjct: 284 VTEKMLKAL 292
>XP_006714713
          Length = 884

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           + EKMLKAL
Sbjct: 374 VTEKMLKAL 382
>XP_005248591
          Length = 884

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           + EKMLKAL
Sbjct: 374 VTEKMLKAL 382
>NP_009117
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>NP_079229
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MVEKMLK 7
           MVEKM+K
Sbjct: 180 MVEKMVK 186
>XP_005260321
          Length = 2365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_005260320
          Length = 2370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723758
          Length = 2386

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723757
          Length = 2404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723756
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723755
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723754
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_006723753
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_005260319
          Length = 2442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   EKMLKAL 9
           EKM+KAL
Sbjct: 303 EKMIKAL 309
>XP_005253995
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  MVEKMLK 7
          MVEKM+K
Sbjct: 44 MVEKMVK 50
>XP_006719669
          Length = 944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MVEKMLK 7
           MVEKM+K
Sbjct: 152 MVEKMVK 158
>NP_005049
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_005237
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           M E+M+KAL
Sbjct: 214 MQEEMIKAL 222
>NP_001006121
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_689798
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_001006118
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_775899
          Length = 4462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    VEKMLKAL 9
            +EK+LKAL
Sbjct: 1410 MEKVLKAL 1417
>XP_005262647
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262646
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262645
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262644
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262643
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262642
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>XP_005262641
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262640
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262634
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>XP_005262633
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262632
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262631
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262574
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262573
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>XP_005262572
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262571
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262570
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>XP_005262569
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005262568
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 28 EKMLKAV 34
>XP_005271980
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           M E+M+KAL
Sbjct: 141 MQEEMIKAL 149
>XP_006714636
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           M E+M+KAL
Sbjct: 214 MQEEMIKAL 222
>XP_006714635
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MVEKMLKAL 9
           M E+M+KAL
Sbjct: 214 MQEEMIKAL 222
>NP_001006117
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_001006120
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  EKMLKAL 9
          EKMLKA+
Sbjct: 21 EKMLKAV 27
>NP_001269
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EKMLKA 8
           EKMLKA
Sbjct: 505 EKMLKA 510
>NP_872302
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EKMLKA 8
           EKMLKA
Sbjct: 392 EKMLKA 397
>NP_958357
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EKMLKAL 9
            EK+LKAL
Sbjct: 1090 EKILKAL 1096
>NP_001020279
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    MVEKMLKAL 9
            MVEK  KAL
Sbjct: 1019 MVEKFGKAL 1027
>NP_002080
          Length = 107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MVEKMLK 7
           ++EKMLK
Sbjct: 96  IIEKMLK 102
>NP_002276
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    MVEKMLKAL 9
            MVEK  KAL
Sbjct: 994  MVEKFGKAL 1002
>XP_006719292
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EKMLKA 8
           EKMLKA
Sbjct: 228 EKMLKA 233
>XP_005264002
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MVEKMLKAL 9
           MVEK  KAL
Sbjct: 663 MVEKFGKAL 671
>XP_005264000
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    MVEKMLKAL 9
            MVEK  KAL
Sbjct: 994  MVEKFGKAL 1002
>XP_006712586
          Length = 1262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    MVEKMLKAL 9
            MVEK  KAL
Sbjct: 1046 MVEKFGKAL 1054
>XP_005263999
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    MVEKMLKAL 9
            MVEK  KAL
Sbjct: 1046 MVEKFGKAL 1054
>XP_005271318
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EKMLKAL 9
            EK+LKAL
Sbjct: 1090 EKILKAL 1096
>XP_005271317
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EKMLKAL 9
            EK+LKAL
Sbjct: 1090 EKILKAL 1096
>XP_005271314
          Length = 1368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    EKMLKAL 9
            EK+LKAL
Sbjct: 1090 EKILKAL 1096
>NP_777592
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  MVEKMLK 7
          M+E+MLK
Sbjct: 49 MIEQMLK 55
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.132    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 368,273
Number of extensions: 655
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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