Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              18    1135
NP_001268885                                                           17    4312
NP_443128                                                              17    4312
NP_008862                                                              16    5631
NP_001273685                                                           16    7355
NP_037499                                                              16    7355
XP_005248216                                                           16    7355
XP_006714024                                                           16    7355
NP_001244950                                                           15    9605
NP_001244948                                                           15    9605
NP_001244949                                                           15    9605
NP_001244951                                                           15    9605
NP_001244952                                                           15    9605
NP_000818                                                              15    9605
NP_001107655                                                           15    9605
NP_015564                                                              15    9605
NP_001070711                                                           15    9605
XP_005258567                                                           15    9605
XP_006718886                                                           15    9605
XP_005271575                                                           15    9605
NP_000820                                                              15    9605
NP_000819                                                              15    9605
NP_789780                                                              15    9605
NP_001077088                                                           15    9605
NP_000817                                                              15    9605
NP_001077089                                                           15    9605
>NP_003290
          Length = 803

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TITLVLKE 9
           TITLVLKE
Sbjct: 246 TITLVLKE 253
>NP_001268885
          Length = 3631

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TITLVLKE 9
           TIT VLKE
Sbjct: 769 TITCVLKE 776
>NP_443128
          Length = 3487

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TITLVLKE 9
           TIT VLKE
Sbjct: 729 TITCVLKE 736
>NP_008862
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MTITLVLKE 9
           MT++L+LK+
Sbjct: 349 MTVSLLLKD 357
>NP_001273685
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TITLVLKE 9
           T+T+VLK+
Sbjct: 649 TVTVVLKD 656
>NP_037499
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TITLVLKE 9
           T+T+VLK+
Sbjct: 648 TVTVVLKD 655
>XP_005248216
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TITLVLKE 9
           T+T+VLK+
Sbjct: 281 TVTVVLKD 288
>XP_006714024
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TITLVLKE 9
           T+T+VLK+
Sbjct: 625 TVTVVLKD 632
>NP_001244950
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 503 LTITLVREE 511
>NP_001244948
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 413 LTITLVREE 421
>NP_001244949
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 398 LTITLVREE 406
>NP_001244951
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 503 LTITLVREE 511
>NP_001244952
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 424 LTITLVREE 432
>NP_000818
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 493 LTITLVREE 501
>NP_001107655
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 493 LTITLVREE 501
>NP_015564
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 509 LTITLVREE 517
>NP_001070711
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 501 LTITLVREE 509
>XP_005258567
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MTITLVLK 8
           MT+ L+LK
Sbjct: 796 MTVPLILK 803
>XP_006718886
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 501 LTITLVREE 509
>XP_005271575
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 501 LTITLVREE 509
>NP_000820
          Length = 902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 501 LTITLVREE 509
>NP_000819
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 509 LTITLVREE 517
>NP_789780
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MTITLVLK 8
           MT+ L+LK
Sbjct: 796 MTVPLILK 803
>NP_001077088
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 500 LTITLVREE 508
>NP_000817
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 500 LTITLVREE 508
>NP_001077089
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MTITLVLKE 9
           +TITLV +E
Sbjct: 453 LTITLVREE 461
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.136    0.319 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,287
Number of extensions: 358
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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