Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     299
NP_000170                                                              20     299
NP_001268422                                                           20     299
NP_001268423                                                           20     299
XP_005264328                                                           20     299
NP_000231                                                              16    5631
NP_001257387                                                           16    5631
NP_055889                                                              16    5631
NP_000370                                                              16    5631
NP_001095841                                                           16    5631
NP_079231                                                              16    5631
XP_006723318                                                           16    5631
NP_060495                                                              16    5631
NP_066276                                                              16    7355
NP_001241686                                                           16    7355
NP_001241688                                                           16    7355
NP_001241687                                                           16    7355
NP_006269                                                              16    7355
NP_001265321                                                           16    7355
NP_001193856                                                           16    7355
XP_005271708                                                           16    7355
XP_005271707                                                           16    7355
XP_005271706                                                           16    7355
XP_006718960                                                           16    7355
XP_006718959                                                           16    7355
XP_006715067                                                           16    7355
NP_001137469                                                           15    9605
NP_001137468                                                           15    9605
NP_060715                                                              15    9605
NP_001257391                                                           15    9605
NP_777631                                                              15    9605
NP_001257393                                                           15    9605
NP_001257395                                                           15    9605
NP_001257390                                                           15    9605
NP_777630                                                              15    9605
NP_777629                                                              15    9605
NP_005052                                                              15    9605
NP_001158508                                                           15    9605
NP_002532                                                              15    9605
XP_005249816                                                           15    9605
XP_005249818                                                           15    9605
XP_006710890                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MSKYDRVVR 9
           +SKYDRVVR
Sbjct: 372 ISKYDRVVR 380
>NP_000170
          Length = 1360

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MSKYDRVVR 9
           +SKYDRVVR
Sbjct: 502 ISKYDRVVR 510
>NP_001268422
          Length = 1058

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MSKYDRVVR 9
           +SKYDRVVR
Sbjct: 200 ISKYDRVVR 208
>NP_001268423
          Length = 1058

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MSKYDRVVR 9
           +SKYDRVVR
Sbjct: 200 ISKYDRVVR 208
>XP_005264328
          Length = 1261

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MSKYDRVVR 9
           +SKYDRVVR
Sbjct: 403 ISKYDRVVR 411
>NP_000231
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           M++Y RV+R
Sbjct: 416 MTQYGRVIR 424
>NP_001257387
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           M++Y RV+R
Sbjct: 283 MTQYGRVIR 291
>NP_055889
          Length = 1770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    MSKYDRVV 8
            MSKYD +V
Sbjct: 1201 MSKYDLLV 1208
>NP_000370
          Length = 1333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  MSKYDRV 7
          +SKYDR+
Sbjct: 55 LSKYDRL 61
>NP_001095841
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YDRVVR 9
           YDRV+R
Sbjct: 332 YDRVIR 337
>NP_079231
          Length = 684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YDRVVR 9
           YDRV+R
Sbjct: 332 YDRVIR 337
>XP_006723318
          Length = 622

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           +SKYD V++
Sbjct: 304 LSKYDTVLK 312
>NP_060495
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           +SKYD V++
Sbjct: 304 LSKYDTVLK 312
>NP_066276
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MSKYDRVVR 9
           +SKY RV R
Sbjct: 183 LSKYGRVKR 191
>NP_001241686
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 138 INKYDVVIR 146
>NP_001241688
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 137 INKYDVVIR 145
>NP_001241687
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 138 INKYDVVIR 146
>NP_006269
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 134 INKYDVVIR 142
>NP_001265321
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           +S+YDR ++
Sbjct: 195 VSRYDRTIQ 203
>NP_001193856
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MSKYDRV 7
            +SK+DRV
Sbjct: 1961 LSKFDRV 1967
>XP_005271708
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 134 INKYDVVIR 142
>XP_005271707
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 138 INKYDVVIR 146
>XP_005271706
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 157 INKYDVVIR 165
>XP_006718960
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 159 INKYDVVIR 167
>XP_006718959
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MSKYDRVVR 9
           ++KYD V+R
Sbjct: 161 INKYDVVIR 169
>XP_006715067
          Length = 4707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MSKYDRV 7
            +SK+DRV
Sbjct: 1961 LSKFDRV 1967
>NP_001137469
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           ++KYDR+
Sbjct: 337 IAKYDRI 343
>NP_001137468
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           ++KYDR+
Sbjct: 489 IAKYDRI 495
>NP_060715
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           ++KYDR+
Sbjct: 546 IAKYDRI 552
>NP_001257391
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_777631
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_001257393
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_001257395
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_001257390
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_777630
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_777629
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
>NP_005052
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MSKYDRVVR 9
           M KY +V+R
Sbjct: 153 MKKYCKVIR 161
>NP_001158508
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           +SKYD++
Sbjct: 555 ISKYDKI 561
>NP_002532
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           +SKYD++
Sbjct: 559 ISKYDKI 565
>XP_005249816
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           +SKYD++
Sbjct: 574 ISKYDKI 580
>XP_005249818
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MSKYDRV 7
           +SKYD++
Sbjct: 570 ISKYDKI 576
>XP_006710890
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  SKYDRV 7
          SKYDR+
Sbjct: 39 SKYDRL 44
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.136    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 436,028
Number of extensions: 685
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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