Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_001130005                                                           17    3301
NP_001191448                                                           17    4312
NP_002552                                                              17    4312
NP_001273428                                                           16    5631
NP_001273425                                                           16    5631
NP_079325                                                              16    5631
NP_001273426                                                           16    5631
NP_055873                                                              16    7355
NP_055211                                                              16    7355
XP_006719854                                                           16    7355
XP_006719853                                                           16    7355
NP_542198                                                              16    7355
NP_057313                                                              15    9605
NP_653271                                                              15    9605
NP_001269353                                                           15    9605
NP_694997                                                              15    9605
NP_005437                                                              15    9605
NP_004425                                                              15    9605
NP_001008707                                                           15    9605
NP_001153026                                                           15    9605
XP_006724432                                                           15    9605
XP_005261876                                                           15    9605
XP_006720137                                                           15    9605
XP_005267457                                                           15    9605
XP_005267456                                                           15    9605
XP_005267455                                                           15    9605
XP_005267454                                                           15    9605
XP_005273935                                                           15    9605
XP_005273934                                                           15    9605
XP_005273933                                                           15    9605
XP_006718554                                                           15    9605
XP_006718553                                                           15    9605
XP_006718552                                                           15    9605
XP_005253033                                                           15    9605
XP_006718315                                                           15    9605
XP_005253032                                                           15    9605
XP_006718314                                                           15    9605
XP_005253031                                                           15    9605
XP_006718313                                                           15    9605
XP_005253030                                                           15    9605
XP_006717969                                                           15    9605
XP_006717968                                                           15    9605
XP_006717967                                                           15    9605
XP_006717966                                                           15    9605
XP_006717965                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MSGESIFFV 9
            MSGES FFV
Sbjct: 1054 MSGESTFFV 1062
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MSGESIFFV 9
            MSGES FFV
Sbjct: 1184 MSGESTFFV 1192
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MSGESIFFV 9
           MSGES FFV
Sbjct: 882 MSGESTFFV 890
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MSGESIFFV 9
           MSGES FFV
Sbjct: 882 MSGESTFFV 890
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    MSGESIFFV 9
            MSGES FFV
Sbjct: 1085 MSGESTFFV 1093
>NP_001130005
          Length = 631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MSGESIF 7
           MSGES+F
Sbjct: 95  MSGESLF 101
>NP_001191448
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GE++FFV
Sbjct: 97  GENVFFV 103
>NP_002552
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GE++FFV
Sbjct: 97  GENVFFV 103
>NP_001273428
          Length = 588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MSGESIFF 8
           + G+SIFF
Sbjct: 166 LKGQSIFF 173
>NP_001273425
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MSGESIFF 8
           + G+SIFF
Sbjct: 219 LKGQSIFF 226
>NP_079325
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MSGESIFF 8
           + G+SIFF
Sbjct: 219 LKGQSIFF 226
>NP_001273426
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MSGESIFF 8
           + G+SIFF
Sbjct: 219 LKGQSIFF 226
>NP_055873
          Length = 1905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSGESIFFV 9
            M+G+S FFV
Sbjct: 1143 MTGKSGFFV 1151
>NP_055211
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GES+F++
Sbjct: 342 GESLFYI 348
>XP_006719854
          Length = 1550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MSGESIFFV 9
           M+G+S FFV
Sbjct: 788 MTGKSGFFV 796
>XP_006719853
          Length = 1809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MSGESIFFV 9
            M+G+S FFV
Sbjct: 1047 MTGKSGFFV 1055
>NP_542198
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GES+F++
Sbjct: 317 GESLFYI 323
>NP_057313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>NP_653271
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MSGESIFF 8
            +SGESI++
Sbjct: 1166 ISGESIYW 1173
>NP_001269353
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MSGESIFF 8
           +SGESI++
Sbjct: 675 ISGESIYW 682
>NP_694997
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 270 SGEVVYFI 277
>NP_005437
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GE++FF+
Sbjct: 106 GENVFFL 112
>NP_004425
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 243 TGETVYFI 250
>NP_001008707
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 262 TGETVYFI 269
>NP_001153026
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  GESIFFV 9
          GE++FF+
Sbjct: 80 GENVFFL 86
>XP_006724432
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  GESIFFV 9
          GE++FF+
Sbjct: 80 GENVFFL 86
>XP_005261876
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GESIFFV 9
           GE++FF+
Sbjct: 106 GENVFFL 112
>XP_006720137
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 262 TGETVYFI 269
>XP_005267457
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 230 TGETVYFI 237
>XP_005267456
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 243 TGETVYFI 250
>XP_005267455
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 249 TGETVYFI 256
>XP_005267454
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   SGESIFFV 9
           +GE+++F+
Sbjct: 262 TGETVYFI 269
>XP_005273935
          Length = 897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 271 SGEVVYFI 278
>XP_005273934
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 270 SGEVVYFI 277
>XP_005273933
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 271 SGEVVYFI 278
>XP_006718554
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 320 SGEVVYFI 327
>XP_006718553
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 321 SGEVVYFI 328
>XP_006718552
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   SGESIFFV 9
           SGE ++F+
Sbjct: 321 SGEVVYFI 328
>XP_005253033
          Length = 258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 172 GETIFF 177
>XP_006718315
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253032
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718314
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253031
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_006718313
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 112 GETIFF 117
>XP_005253030
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   GESIFF 8
           GE+IFF
Sbjct: 172 GETIFF 177
>XP_006717969
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SGESIFF 8
          SGE +FF
Sbjct: 37 SGEPLFF 43
>XP_006717968
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SGESIFF 8
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717967
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SGESIFF 8
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717966
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SGESIFF 8
           SGE +FF
Sbjct: 550 SGEPLFF 556
>XP_006717965
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SGESIFF 8
           SGE +FF
Sbjct: 556 SGEPLFF 562
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.145    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 573,395
Number of extensions: 704
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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