Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     509
XP_005268094                                                           20     509
NP_000224                                                              17    3301
XP_005264366                                                           17    3301
XP_006712078                                                           17    3301
NP_059988                                                              17    4312
NP_115691                                                              16    5631
XP_005263560                                                           16    5631
NP_001193770                                                           16    7355
NP_001186308                                                           16    7355
NP_001131074                                                           16    7355
NP_057039                                                              16    7355
NP_612373                                                              16    7355
NP_001186307                                                           16    7355
NP_004184                                                              16    7355
XP_006718114                                                           16    7355
XP_005270318                                                           16    7355
XP_006718113                                                           16    7355
XP_006718112                                                           16    7355
XP_006718111                                                           16    7355
XP_006718110                                                           16    7355
XP_005263397                                                           16    7355
XP_005263396                                                           16    7355
XP_005263395                                                           16    7355
XP_005264409                                                           16    7355
XP_005264408                                                           16    7355
NP_001153115                                                           15    9605
NP_060819                                                              15    9605
NP_001164491                                                           15    9605
NP_001158220                                                           15    9605
NP_001158219                                                           15    9605
NP_009142                                                              15    9605
NP_001158218                                                           15    9605
NP_059113                                                              15    9605
NP_689636                                                              15    9605
NP_116256                                                              15    9605
XP_005262135                                                           15    9605
XP_005262134                                                           15    9605
XP_005255016                                                           15    9605
XP_005255015                                                           15    9605
XP_005255014                                                           15    9605
XP_006720666                                                           15    9605
XP_006720665                                                           15    9605
XP_005255012                                                           15    9605
XP_005254442                                                           15    9605
XP_006719091                                                           15    9605
XP_006719090                                                           15    9605
XP_005253235                                                           15    9605
NP_002364                                                              15    9605
>NP_000360
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MRLDQKIRL 9
           MRLD+KIRL
Sbjct: 527 MRLDRKIRL 535
>XP_005268094
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MRLDQKIRL 9
           MRLD+KIRL
Sbjct: 527 MRLDRKIRL 535
>NP_000224
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           + LDQK+RL
Sbjct: 472 IHLDQKLRL 480
>XP_005264366
          Length = 380

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           + LDQK+RL
Sbjct: 153 IHLDQKLRL 161
>XP_006712078
          Length = 389

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           + LDQK+RL
Sbjct: 162 IHLDQKLRL 170
>NP_059988
          Length = 368

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+RL
Sbjct: 264 LDQKLRL 270
>NP_115691
          Length = 321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           M+L+QK+R
Sbjct: 156 MQLEQKVR 163
>XP_005263560
          Length = 254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  MRLDQKIR 8
          M+L+QK+R
Sbjct: 89 MQLEQKVR 96
>NP_001193770
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RLDQKI 7
           RLDQKI
Sbjct: 432 RLDQKI 437
>NP_001186308
          Length = 1855

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 776 LRLDEALRL 784
>NP_001131074
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  MRLDQKI 7
          +R+DQKI
Sbjct: 80 LRIDQKI 86
>NP_057039
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MRLDQKI 7
           +R+DQKI
Sbjct: 103 LRIDQKI 109
>NP_612373
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           M LD++IRL
Sbjct: 792 MYLDEEIRL 800
>NP_001186307
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 777 LRLDEALRL 785
>NP_004184
          Length = 1859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 776 LRLDEALRL 784
>XP_006718114
          Length = 1850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 810 LRLDEALRL 818
>XP_005270318
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 777 LRLDEALRL 785
>XP_006718113
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 798 LRLDEALRL 806
>XP_006718112
          Length = 1889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 810 LRLDEALRL 818
>XP_006718111
          Length = 1892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 809 LRLDEALRL 817
>XP_006718110
          Length = 1893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           +RLD+ +RL
Sbjct: 810 LRLDEALRL 818
>XP_005263397
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           M LD++IRL
Sbjct: 487 MYLDEEIRL 495
>XP_005263396
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           M LD++IRL
Sbjct: 679 MYLDEEIRL 687
>XP_005263395
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           M LD++IRL
Sbjct: 713 MYLDEEIRL 721
>XP_005264409
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MRLDQKI 7
           +R+DQKI
Sbjct: 103 LRIDQKI 109
>XP_005264408
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MRLDQKI 7
           +R+DQKI
Sbjct: 103 LRIDQKI 109
>NP_001153115
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>NP_060819
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>NP_001164491
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MRLDQKIRL 9
          + LD+KI+L
Sbjct: 42 LSLDEKIKL 50
>NP_001158220
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>NP_001158219
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>NP_009142
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>NP_001158218
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>NP_059113
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MRLDQKIRL 9
           + LD+KI+L
Sbjct: 230 VHLDEKIKL 238
>NP_689636
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MRLDQKIRL 9
          + LD+KI+L
Sbjct: 42 LSLDEKIKL 50
>NP_116256
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLDQKIR 8
           RL+QK+R
Sbjct: 622 RLEQKLR 628
>XP_005262135
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MRLDQKIRL 9
          + LD+KI+L
Sbjct: 42 LSLDEKIKL 50
>XP_005262134
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MRLDQKIRL 9
          + LD+KI+L
Sbjct: 42 LSLDEKIKL 50
>XP_005255016
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_005255015
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_005255014
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_006720666
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_006720665
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_005255012
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LDQKIRL 9
           LDQK+R+
Sbjct: 253 LDQKLRV 259
>XP_005254442
          Length = 3041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LDQKIR 8
            LDQK+R
Sbjct: 1737 LDQKVR 1742
>XP_006719091
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>XP_006719090
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MRLDQKIR 8
           +RL+QKI+
Sbjct: 207 VRLEQKIK 214
>XP_005253235
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RLDQKIR 8
           RL+QK+R
Sbjct: 623 RLEQKLR 629
>NP_002364
          Length = 2803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LDQKIR 8
            LDQK+R
Sbjct: 1499 LDQKVR 1504
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.152    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 442,544
Number of extensions: 752
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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