Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     390
NP_001091680                                                           20     390
NP_001091679                                                           20     390
XP_006713048                                                           20     390
XP_006713047                                                           20     390
XP_006713046                                                           20     390
XP_005264943                                                           20     390
NP_005463                                                              18    1935
NP_001363                                                              17    3301
XP_006721528                                                           17    3301
NP_056996                                                              17    4312
XP_005250985                                                           17    4312
XP_006716634                                                           17    4312
XP_006726568                                                           16    5631
XP_006717420                                                           16    5631
XP_006710277                                                           16    5631
NP_005075                                                              16    7355
NP_001244926                                                           16    7355
NP_003310                                                              16    7355
NP_001161829                                                           16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
XP_005249465                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_001108451                                                           15    9605
NP_001108454                                                           15    9605
NP_003713                                                              15    9605
NP_006493                                                              15    9605
NP_001108450                                                           15    9605
NP_001108452                                                           15    9605
NP_001108453                                                           15    9605
NP_000205                                                              15    9605
NP_001278425                                                           15    9605
NP_001035531                                                           15    9605
NP_002811                                                              15    9605
NP_945317                                                              15    9605
NP_945316                                                              15    9605
NP_945315                                                              15    9605
NP_892011                                                              15    9605
NP_001378                                                              15    9605
NP_001135865                                                           15    9605
NP_006394                                                              15    9605
NP_001184223                                                           15    9605
NP_001269285                                                           15    9605
NP_733787                                                              15    9605
NP_599028                                                              15    9605
NP_439897                                                              15    9605
NP_065832                                                              15    9605
NP_065692                                                              15    9605
NP_001155057                                                           15    9605
XP_005253491                                                           15    9605
XP_006719178                                                           15    9605
XP_005251545                                                           15    9605
XP_006715181                                                           15    9605
XP_005249243                                                           15    9605
XP_005247903                                                           15    9605
XP_005247901                                                           15    9605
XP_005247900                                                           15    9605
NP_004052                                                              15    9605
NP_001005245                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 202 MQNTNDVET 210
>NP_001091680
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 202 MQNTNDVET 210
>NP_001091679
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 202 MQNTNDVET 210
>XP_006713048
          Length = 720

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 202 MQNTNDVET 210
>XP_006713047
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 195 MQNTNDVET 203
>XP_006713046
          Length = 774

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 195 MQNTNDVET 203
>XP_005264943
          Length = 781

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MQNTNGVET 9
           MQNTN VET
Sbjct: 202 MQNTNDVET 210
>NP_005463
          Length = 103

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 MQNTNGVET 9
         M+ TNG ET
Sbjct: 1 METTNGTET 9
>NP_001363
          Length = 4486

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MQNTNGVE 8
            +QNT G+E
Sbjct: 2997 LQNTEGIE 3004
>XP_006721528
          Length = 3869

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MQNTNGVE 8
            +QNT G+E
Sbjct: 2997 LQNTEGIE 3004
>NP_056996
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QNTNGVET 9
           +NT GVET
Sbjct: 868 ENTPGVET 875
>XP_005250985
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QNTNGVET 9
           +NT GVET
Sbjct: 868 ENTPGVET 875
>XP_006716634
          Length = 1420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QNTNGVET 9
           +NT GVET
Sbjct: 882 ENTPGVET 889
>XP_006726568
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NTNGVET 9
          NTNGV++
Sbjct: 61 NTNGVDS 67
>XP_006717420
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NTNGVET 9
          NTNGV++
Sbjct: 61 NTNGVDS 67
>XP_006710277
          Length = 142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NTNGVET 9
          NTNGV++
Sbjct: 61 NTNGVDS 67
>NP_005075
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   MQNTNGVE 8
           +QN++G+E
Sbjct: 431 LQNSSGIE 438
>NP_001244926
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1 MQNTNGVET 9
         MQ+T GV+T
Sbjct: 1 MQSTFGVKT 9
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 22225 LENTAGVKT 22233
>NP_001161829
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   MQNTNGVE 8
           +QN++G+E
Sbjct: 431 LQNSSGIE 438
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 22350 LENTAGVKT 22358
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 29649 LENTAGVKT 29657
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 28722 LENTAGVKT 28730
>XP_005249465
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   MQNTNGVE 8
           +QN++G+E
Sbjct: 431 LQNSSGIE 438
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 17962 LENTAGVKT 17970
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 19321 LENTAGVKT 19329
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 29277 LENTAGVKT 29285
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 30783 LENTAGVKT 30791
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 31290 LENTAGVKT 31298
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1     MQNTNGVET 9
             ++NT GV+T
Sbjct: 22417 LENTAGVKT 22425
>NP_001108451
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 380 QNTHGIQ 386
>NP_001108454
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 286 QNTHGIQ 292
>NP_003713
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 380 QNTHGIQ 386
>NP_006493
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NTNGVET 9
           NT+G++T
Sbjct: 407 NTSGIQT 413
>NP_001108450
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 380 QNTHGIQ 386
>NP_001108452
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 286 QNTHGIQ 292
>NP_001108453
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 286 QNTHGIQ 292
>NP_000205
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  MQNTNG 6
          MQN NG
Sbjct: 42 MQNVNG 47
>NP_001278425
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTNGVE 8
           N+NGVE
Sbjct: 141 NSNGVE 146
>NP_001035531
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   NTNGVE 8
           N+NGVE
Sbjct: 141 NSNGVE 146
>NP_002811
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QNTNGVET 9
           Q TN VET
Sbjct: 106 QETNKVET 113
>NP_945317
          Length = 177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QNTNGVET 9
           Q TN VET
Sbjct: 106 QETNKVET 113
>NP_945316
          Length = 177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QNTNGVET 9
           Q TN VET
Sbjct: 106 QETNKVET 113
>NP_945315
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QNTNGVET 9
           Q TN VET
Sbjct: 106 QETNKVET 113
>NP_892011
          Length = 174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QNTNGVE 8
          QNT G+E
Sbjct: 35 QNTGGLE 41
>NP_001378
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QNTNGVE 8
           + TNGVE
Sbjct: 353 EGTNGVE 359
>NP_001135865
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QNTNGVE 8
          QNT G+E
Sbjct: 35 QNTGGLE 41
>NP_006394
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  QNTNGVE 8
          QNT G+E
Sbjct: 35 QNTGGLE 41
>NP_001184223
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   QNTNGVE 8
           + TNGVE
Sbjct: 467 EGTNGVE 473
>NP_001269285
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MQNTNGVE 8
           M+NT G+E
Sbjct: 278 MENTYGLE 285
>NP_733787
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NTNGVET 9
           NT G+ET
Sbjct: 623 NTEGLET 629
>NP_599028
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MQNTNGVE 8
           M+NT G+E
Sbjct: 278 MENTYGLE 285
>NP_439897
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MQNTNGVE 8
           M+NT G+E
Sbjct: 278 MENTYGLE 285
>NP_065832
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NTNGVET 9
           NT G+ET
Sbjct: 452 NTEGLET 458
>NP_065692
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  QNTNGVET 9
          QN NG E+
Sbjct: 73 QNPNGTES 80
>NP_001155057
          Length = 265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  QNTNGVET 9
          QN NG E+
Sbjct: 73 QNPNGTES 80
>XP_005253491
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  QNTNGVET 9
          Q TN VET
Sbjct: 88 QETNKVET 95
>XP_006719178
          Length = 177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QNTNGVET 9
           Q TN VET
Sbjct: 106 QETNKVET 113
>XP_005251545
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  QNTNGVET 9
          QN NG E+
Sbjct: 64 QNPNGTES 71
>XP_006715181
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NTNGVET 9
           NT+G++T
Sbjct: 255 NTSGIQT 261
>XP_005249243
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   NTNGVET 9
           NT+G++T
Sbjct: 345 NTSGIQT 351
>XP_005247903
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 376 QNTHGIQ 382
>XP_005247901
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 363 QNTHGIQ 369
>XP_005247900
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QNTNGVE 8
           QNT+G++
Sbjct: 376 QNTHGIQ 382
>NP_004052
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NTNGVET 9
           NT G+ET
Sbjct: 546 NTAGIET 552
>NP_001005245
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1 MQNTNG 6
         M NTNG
Sbjct: 1 MSNTNG 6
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.112    0.289 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 665,784
Number of extensions: 1305
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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