Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     299
NP_006663                                                              17    2528
NP_696961                                                              17    2528
NP_001166101                                                           17    3301
NP_443180                                                              17    3301
XP_006723065                                                           17    3301
XP_005258546                                                           17    3301
XP_006723064                                                           17    3301
XP_005258545                                                           17    3301
XP_005258544                                                           17    3301
XP_006723063                                                           17    3301
XP_006723062                                                           17    3301
NP_878918                                                              17    4312
NP_055995                                                              17    4312
NP_005654                                                              17    4312
XP_006720147                                                           17    4312
XP_005267517                                                           17    4312
XP_005267516                                                           17    4312
XP_005267515                                                           17    4312
XP_005267514                                                           17    4312
XP_005267513                                                           17    4312
XP_005267512                                                           17    4312
XP_005267511                                                           17    4312
XP_006713980                                                           17    4312
XP_006713979                                                           17    4312
NP_004659                                                              16    5631
NP_079029                                                              16    5631
NP_008892                                                              16    5631
XP_005273723                                                           16    5631
XP_005273722                                                           16    5631
XP_006716232                                                           16    5631
XP_006716231                                                           16    5631
XP_006712824                                                           16    5631
NP_116053                                                              16    5631
NP_001121369                                                           16    7355
NP_056087                                                              16    7355
NP_005934                                                              16    7355
NP_113602                                                              16    7355
NP_001247434                                                           16    7355
NP_116562                                                              16    7355
NP_001247433                                                           16    7355
NP_110397                                                              16    7355
NP_066580                                                              16    7355
NP_001068566                                                           16    7355
NP_001275681                                                           16    7355
XP_005255927                                                           16    7355
XP_005255926                                                           16    7355
XP_005255925                                                           16    7355
XP_005255924                                                           16    7355
XP_005253535                                                           16    7355
XP_005253534                                                           16    7355
XP_005253531                                                           16    7355
XP_006718985                                                           16    7355
XP_006718984                                                           16    7355
XP_006715821                                                           16    7355
XP_005249868                                                           16    7355
NP_602307                                                              16    7355
NP_001230913                                                           15    9605
NP_068810                                                              15    9605
NP_001138610                                                           15    9605
NP_001230914                                                           15    9605
NP_004949                                                              15    9605
NP_060666                                                              15    9605
NP_001171726                                                           15    9605
NP_536724                                                              15    9605
NP_940916                                                              15    9605
NP_059115                                                              15    9605
NP_077741                                                              15    9605
NP_001932                                                              15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
NP_005889                                                              15    9605
NP_976240                                                              15    9605
>NP_002430
          Length = 1137

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   PLELQYIE 9
           PLELQYIE
Sbjct: 231 PLELQYIE 238
>NP_006663
          Length = 546

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MPLELQYIE 9
           MPLEL++++
Sbjct: 215 MPLELEWLD 223
>NP_696961
          Length = 548

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MPLELQYIE 9
           MPLEL++++
Sbjct: 217 MPLELEWLD 225
>NP_001166101
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MPLELQYIE 9
          +PL LQY+E
Sbjct: 3  VPLLLQYLE 11
>NP_443180
          Length = 1126

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_006723065
          Length = 1162

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MPLELQYIE 9
          +PL LQY+E
Sbjct: 3  VPLLLQYLE 11
>XP_005258546
          Length = 1259

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_006723064
          Length = 1270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_005258545
          Length = 1287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_005258544
          Length = 1288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_006723063
          Length = 1297

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>XP_006723062
          Length = 1298

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL LQY+E
Sbjct: 139 VPLLLQYLE 147
>NP_878918
          Length = 6907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>NP_055995
          Length = 6885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>NP_005654
          Length = 539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MPLELQYI 8
           +PLE QY+
Sbjct: 148 LPLECQYL 155
>XP_006720147
          Length = 4788

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267517
          Length = 6883

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267516
          Length = 6884

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267515
          Length = 6899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267514
          Length = 6908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267513
          Length = 6921

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267512
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_005267511
          Length = 6922

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    MPLELQYIE 9
            +PLELQ +E
Sbjct: 1712 IPLELQVME 1720
>XP_006713980
          Length = 458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MPLELQYI 8
          +PLE QY+
Sbjct: 67 LPLECQYL 74
>XP_006713979
          Length = 564

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MPLELQYI 8
           +PLE QY+
Sbjct: 173 LPLECQYL 180
>NP_004659
          Length = 1857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PLELQYIE 9
            PL+L YIE
Sbjct: 1793 PLKLGYIE 1800
>NP_079029
          Length = 1316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL +QY E
Sbjct: 433 LPLGIQYFE 441
>NP_008892
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  MPLELQYIE 9
          MPL+ QY E
Sbjct: 4  MPLKAQYQE 12
>XP_005273723
          Length = 453

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL  QY+E
Sbjct: 151 LPLTTQYLE 159
>XP_005273722
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL  QY+E
Sbjct: 179 LPLTTQYLE 187
>XP_006716232
          Length = 2753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PLELQYIE 9
            PL+L YIE
Sbjct: 2689 PLKLGYIE 2696
>XP_006716231
          Length = 2753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PLELQYIE 9
            PL+L YIE
Sbjct: 2689 PLKLGYIE 2696
>XP_006712824
          Length = 1056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL +QY E
Sbjct: 433 LPLGIQYFE 441
>NP_116053
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL  QY+E
Sbjct: 179 LPLTTQYLE 187
>NP_001121369
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 427 LQLQYLE 433
>NP_056087
          Length = 1315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 427 LQLQYLE 433
>NP_005934
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MPLELQYIE 9
           +PL++++IE
Sbjct: 239 LPLDVRFIE 247
>NP_113602
          Length = 1019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 130 IPLELQF 136
>NP_001247434
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 130 IPLELQF 136
>NP_116562
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 107 IPLELQF 113
>NP_001247433
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 107 IPLELQF 113
>NP_110397
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PLELQYIE 9
          P+E QY E
Sbjct: 10 PMEAQYAE 17
>NP_066580
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL + YIE
Sbjct: 176 LPLGISYIE 184
>NP_001068566
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MPLELQYIE 9
           +PL++++IE
Sbjct: 239 LPLDVRFIE 247
>NP_001275681
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PLELQYIE 9
          P+E QY E
Sbjct: 10 PMEAQYAE 17
>XP_005255927
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 431 LQLQYLE 437
>XP_005255926
          Length = 1269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 427 LQLQYLE 433
>XP_005255925
          Length = 1273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 431 LQLQYLE 437
>XP_005255924
          Length = 1281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           L+LQY+E
Sbjct: 427 LQLQYLE 433
>XP_005253535
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL + YIE
Sbjct: 174 LPLGISYIE 182
>XP_005253534
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL + YIE
Sbjct: 156 LPLGISYIE 164
>XP_005253531
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL + YIE
Sbjct: 176 LPLGISYIE 184
>XP_006718985
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PLELQYIE 9
          P+E QY E
Sbjct: 10 PMEAQYAE 17
>XP_006718984
          Length = 253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  PLELQYIE 9
          P+E QY E
Sbjct: 10 PMEAQYAE 17
>XP_006715821
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 130 IPLELQF 136
>XP_005249868
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MPLELQY 7
           +PLELQ+
Sbjct: 130 IPLELQF 136
>NP_602307
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MPLELQYIE 9
           +PL + YIE
Sbjct: 176 LPLGISYIE 184
>NP_001230913
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PLELQYI 8
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_068810
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PLELQYI 8
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_001138610
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PLELQYI 8
           P+E QY+
Sbjct: 280 PMEFQYL 286
>NP_001230914
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   PLELQYI 8
           P+E QY+
Sbjct: 283 PMEFQYL 289
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LELQYI 8
            LELQY+
Sbjct: 2121 LELQYV 2126
>NP_060666
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL+ +YIE
Sbjct: 295 VPLKHEYIE 303
>NP_001171726
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MPLELQYIE 9
           +PL+ +YIE
Sbjct: 295 VPLKHEYIE 303
>NP_536724
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   PLELQYI 8
           P+E++YI
Sbjct: 130 PMEMRYI 136
>NP_940916
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   PLELQYI 8
           P+EL+Y+
Sbjct: 719 PVELRYV 725
>NP_059115
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   LELQYIE 9
           +E+QY+E
Sbjct: 96  IEVQYVE 102
>NP_077741
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PLELQYIE 9
           PL L YIE
Sbjct: 182 PLNLFYIE 189
>NP_001932
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PLELQYIE 9
           PL L YIE
Sbjct: 182 PLNLFYIE 189
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LELQYI 8
            LELQY+
Sbjct: 1894 LELQYV 1899
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LELQYI 8
            LELQY+
Sbjct: 2121 LELQYV 2126
>NP_005889
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LELQYI 8
           LELQY+
Sbjct: 150 LELQYV 155
>NP_976240
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LELQYI 8
           LELQY+
Sbjct: 150 LELQYV 155
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.144    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 689,303
Number of extensions: 1456
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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