Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     299
NP_000170                                                              20     299
NP_001268422                                                           20     299
NP_001268423                                                           20     299
XP_005264328                                                           20     299
NP_085135                                                              18    1935
XP_005258413                                                           18    1935
NP_001229277                                                           17    3301
NP_006552                                                              16    5631
NP_001274420                                                           16    5631
NP_001092275                                                           16    5631
NP_001012421                                                           16    5631
NP_001012419                                                           16    5631
XP_006726609                                                           16    5631
XP_006719787                                                           16    5631
XP_006717432                                                           16    5631
XP_005272589                                                           16    5631
XP_005272582                                                           16    5631
XP_005272576                                                           16    5631
XP_006712026                                                           16    5631
XP_005264244                                                           16    5631
XP_006710027                                                           16    5631
NP_115626                                                              16    5631
NP_065857                                                              16    7355
NP_001019389                                                           16    7355
NP_005871                                                              16    7355
NP_001139                                                              16    7355
NP_689785                                                              16    7355
XP_006726566                                                           16    7355
XP_005267311                                                           16    7355
XP_005267310                                                           16    7355
XP_005267307                                                           16    7355
XP_006720066                                                           16    7355
XP_006717411                                                           16    7355
XP_006717028                                                           16    7355
XP_006717027                                                           16    7355
XP_005272226                                                           16    7355
XP_006714257                                                           16    7355
XP_005263002                                                           16    7355
XP_005262999                                                           16    7355
XP_006714252                                                           16    7355
XP_006714251                                                           16    7355
XP_006714250                                                           16    7355
XP_006710279                                                           16    7355
NP_065107                                                              15    9605
NP_114172                                                              15    9605
NP_065944                                                              15    9605
NP_001137290                                                           15    9605
NP_036442                                                              15    9605
NP_002566                                                              15    9605
NP_997205                                                              15    9605
NP_001129735                                                           15    9605
NP_443179                                                              15    9605
XP_006722712                                                           15    9605
XP_005266703                                                           15    9605
XP_005253773                                                           15    9605
XP_006711753                                                           15    9605
NP_001092763                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           M+VPDKISE
Sbjct: 669 MVVPDKISE 677
>NP_000170
          Length = 1360

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           M+VPDKISE
Sbjct: 799 MVVPDKISE 807
>NP_001268422
          Length = 1058

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           M+VPDKISE
Sbjct: 497 MVVPDKISE 505
>NP_001268423
          Length = 1058

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           M+VPDKISE
Sbjct: 497 MVVPDKISE 505
>XP_005264328
          Length = 1261

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           M+VPDKISE
Sbjct: 700 MVVPDKISE 708
>NP_085135
          Length = 2248

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVPDKISE 9
            LVPDK++E
Sbjct: 1564 LVPDKLNE 1571
>XP_005258413
          Length = 2249

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LVPDKISE 9
            LVPDK++E
Sbjct: 1565 LVPDKLNE 1572
>NP_001229277
          Length = 104

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LVPDKIS 8
          LVPDK+S
Sbjct: 44 LVPDKLS 50
>NP_006552
          Length = 521

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  MLVPDKIS 8
          +LVPD+I+
Sbjct: 19 LLVPDRIN 26
>NP_001274420
          Length = 1795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LVPDKIS 8
            +VPDK+S
Sbjct: 1467 IVPDKLS 1473
>NP_001092275
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 301 VPEKVSE 307
>NP_001012421
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 301 VPEKVSE 307
>NP_001012419
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 301 VPEKVSE 307
>XP_006726609
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MLVPDKISE 9
            +L+P+KI+E
Sbjct: 1273 ILLPEKINE 1281
>XP_006719787
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MLVPDKISE 9
            +L+P+KI+E
Sbjct: 1273 ILLPEKINE 1281
>XP_006717432
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  MLVPDKIS 8
          +LVPD+I+
Sbjct: 19 LLVPDRIN 26
>XP_005272589
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 300 VPEKVSE 306
>XP_005272582
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 300 VPEKVSE 306
>XP_005272576
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 300 VPEKVSE 306
>XP_006712026
          Length = 937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LVPDKIS 8
           +VPDK+S
Sbjct: 609 IVPDKLS 615
>XP_005264244
          Length = 1795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LVPDKIS 8
            +VPDK+S
Sbjct: 1467 IVPDKLS 1473
>XP_006710027
          Length = 2837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MLVPDKISE 9
            +L+P+KI+E
Sbjct: 1272 ILLPEKINE 1280
>NP_115626
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VPDKISE 9
           VP+K+SE
Sbjct: 301 VPEKVSE 307
>NP_065857
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>NP_001019389
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>NP_005871
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   PDKISE 9
           PDK+SE
Sbjct: 345 PDKLSE 350
>NP_001139
          Length = 3957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3181 LLPDDVSE 3188
>NP_689785
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           ++VP+ ISE
Sbjct: 204 LMVPEDISE 212
>XP_006726566
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           +L+PD +SE
Sbjct: 388 VLLPDPLSE 396
>XP_005267311
          Length = 755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>XP_005267310
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>XP_005267307
          Length = 788

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>XP_006720066
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          +VPD+I E
Sbjct: 58 IVPDEIEE 65
>XP_006717411
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           +L+PD +SE
Sbjct: 388 VLLPDPLSE 396
>XP_006717028
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           ++VP+ ISE
Sbjct: 132 LMVPEDISE 140
>XP_006717027
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           ++VP+ ISE
Sbjct: 159 LMVPEDISE 167
>XP_005272226
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           ++VP+ ISE
Sbjct: 216 LMVPEDISE 224
>XP_006714257
          Length = 4145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3190 LLPDDVSE 3197
>XP_005263002
          Length = 4072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3148 LLPDDVSE 3155
>XP_005262999
          Length = 4147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3192 LLPDDVSE 3199
>XP_006714252
          Length = 4153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3198 LLPDDVSE 3205
>XP_006714251
          Length = 4165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3210 LLPDDVSE 3217
>XP_006714250
          Length = 4190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LVPDKISE 9
            L+PD +SE
Sbjct: 3235 LLPDDVSE 3242
>XP_006710279
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLVPDKISE 9
           +L+PD +SE
Sbjct: 388 VLLPDPLSE 396
>NP_065107
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVPDKISE 9
           LVP  ISE
Sbjct: 519 LVPQSISE 526
>NP_114172
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  MLVPDKISE 9
          MLVP  +SE
Sbjct: 88 MLVPVPVSE 96
>NP_065944
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LVPDKIS 8
           +VP+KIS
Sbjct: 160 IVPEKIS 166
>NP_001137290
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           +L+PD+I++
Sbjct: 266 LLLPDEIAD 274
>NP_036442
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          LVP +ISE
Sbjct: 19 LVPKEISE 26
>NP_002566
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   MLVPDKISE 9
           +L+PD+I++
Sbjct: 266 LLLPDEIAD 274
>NP_997205
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MLVPDKISE 9
          +L PD+I E
Sbjct: 40 VLTPDRIPE 48
>NP_001129735
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MLVPDKISE 9
          +L PDKI +
Sbjct: 41 VLTPDKIPD 49
>NP_443179
          Length = 2170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1    MLVPDKI 7
            +++PDK+
Sbjct: 1266 LIIPDKV 1272
>XP_006722712
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MLVPDKISE 9
          +L PDKI +
Sbjct: 41 VLTPDKIPD 49
>XP_005266703
          Length = 1501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   MLVPDKI 7
           +++PDK+
Sbjct: 597 LIIPDKV 603
>XP_005253773
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LVPDKISE 9
           LVP  ISE
Sbjct: 476 LVPQSISE 483
>XP_006711753
          Length = 1521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  MLVPDKISE 9
          + +PD +SE
Sbjct: 14 LTIPDAVSE 22
>NP_001092763
          Length = 1234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LVPDKISE 9
          LVP +ISE
Sbjct: 19 LVPKEISE 26
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.135    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 645,591
Number of extensions: 694
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package