Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              21     229
NP_001087241                                                           21     229
XP_006714101                                                           21     229
XP_005265799                                                           21     229
XP_005265798                                                           21     229
XP_005265797                                                           21     229
NP_277042                                                              17    3301
NP_277043                                                              17    3301
NP_000153                                                              17    3301
NP_002903                                                              17    3301
NP_001273361                                                           17    3301
NP_001273360                                                           17    3301
XP_006715607                                                           17    3301
XP_006715606                                                           17    3301
NP_060311                                                              17    4312
NP_110407                                                              17    4312
NP_848599                                                              17    4312
XP_006713081                                                           17    4312
NP_004954                                                              16    5631
NP_001137481                                                           16    5631
NP_001137482                                                           16    5631
NP_001137480                                                           16    5631
NP_001137475                                                           16    5631
NP_001137477                                                           16    5631
NP_001137478                                                           16    5631
NP_001137476                                                           16    5631
NP_115928                                                              16    5631
XP_005262403                                                           16    5631
XP_005262402                                                           16    5631
XP_005262401                                                           16    5631
XP_005262400                                                           16    5631
XP_005262399                                                           16    5631
NP_997005                                                              16    7355
NP_036230                                                              16    7355
NP_001171554                                                           16    7355
NP_000392                                                              16    7355
NP_071505                                                              16    7355
NP_071320                                                              16    7355
NP_003874                                                              16    7355
XP_006717093                                                           16    7355
XP_005264590                                                           16    7355
XP_005264589                                                           16    7355
XP_005264588                                                           16    7355
XP_005264587                                                           16    7355
XP_005264585                                                           16    7355
XP_005264584                                                           16    7355
XP_005264583                                                           16    7355
XP_005264582                                                           16    7355
XP_005264581                                                           16    7355
NP_055527                                                              15    9605
NP_006721                                                              15    9605
NP_001009932                                                           15    9605
NP_001009933                                                           15    9605
NP_001009934                                                           15    9605
NP_000664                                                              15    9605
NP_001159976                                                           15    9605
NP_001171953                                                           15    9605
NP_000967                                                              15    9605
NP_001431                                                              15    9605
XP_005277886                                                           15    9605
XP_006724302                                                           15    9605
XP_006721170                                                           15    9605
XP_006721169                                                           15    9605
XP_005255780                                                           15    9605
XP_006716365                                                           15    9605
NP_037505                                                              15    9605
>NP_000213
          Length = 976

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 415 ILTYDRLVN 423
>NP_001087241
          Length = 972

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 415 ILTYDRLVN 423
>XP_006714101
          Length = 526

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 416 ILTYDRLVN 424
>XP_005265799
          Length = 973

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 416 ILTYDRLVN 424
>XP_005265798
          Length = 976

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 416 ILTYDRLVN 424
>XP_005265797
          Length = 977

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MLTYDRLVN 9
           +LTYDRLVN
Sbjct: 416 ILTYDRLVN 424
>NP_277042
          Length = 466

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MLTYDRLVN 9
           +L YDRLV+
Sbjct: 271 LLEYDRLVD 279
>NP_277043
          Length = 464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MLTYDRLVN 9
           +L YDRLV+
Sbjct: 269 LLEYDRLVD 277
>NP_000153
          Length = 465

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MLTYDRLVN 9
           +L YDRLV+
Sbjct: 270 LLEYDRLVD 278
>NP_002903
          Length = 3130

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    MLTYDR 6
            MLTYDR
Sbjct: 2934 MLTYDR 2939
>NP_001273361
          Length = 3052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    MLTYDR 6
            MLTYDR
Sbjct: 2856 MLTYDR 2861
>NP_001273360
          Length = 3052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    MLTYDR 6
            MLTYDR
Sbjct: 2856 MLTYDR 2861
>XP_006715607
          Length = 3052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    MLTYDR 6
            MLTYDR
Sbjct: 2856 MLTYDR 2861
>XP_006715606
          Length = 3130

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    MLTYDR 6
            MLTYDR
Sbjct: 2934 MLTYDR 2939
>NP_060311
          Length = 166

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YDRLVN 9
           YDRL+N
Sbjct: 105 YDRLIN 110
>NP_110407
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLTYDRLVN 9
           ML YD +VN
Sbjct: 149 MLQYDAVVN 157
>NP_848599
          Length = 3092

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YDRLVN 9
            YDRL+N
Sbjct: 2132 YDRLIN 2137
>XP_006713081
          Length = 3964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    YDRLVN 9
            YDRL+N
Sbjct: 2155 YDRLIN 2160
>NP_004954
          Length = 1073

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLTYDRLVN 9
           +LTYD  VN
Sbjct: 394 LLTYDTHVN 402
>NP_001137481
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137482
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137480
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137475
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137477
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137478
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_001137476
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_115928
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>XP_005262403
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>XP_005262402
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>XP_005262401
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>XP_005262400
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>XP_005262399
          Length = 845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           LT+D L+N
Sbjct: 465 LTFDALIN 472
>NP_997005
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MLTYDRL 7
           +LTYDR+
Sbjct: 460 VLTYDRV 466
>NP_036230
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TYDRLVN 9
           TY+R++N
Sbjct: 229 TYNRIIN 235
>NP_001171554
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MLTYDRL 7
           +LTYDR+
Sbjct: 470 VLTYDRV 476
>NP_000392
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MLTYDRL 7
           +LTYDR+
Sbjct: 493 VLTYDRV 499
>NP_071505
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 200 LSYDEVVN 207
>NP_071320
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 189 LSYDEVVN 196
>NP_003874
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MLTYDR 6
           +LTYDR
Sbjct: 384 LLTYDR 389
>XP_006717093
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TYDRLVN 9
           TY+R++N
Sbjct: 229 TYNRIIN 235
>XP_005264590
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LTYDRLVN 9
          L+YD +VN
Sbjct: 60 LSYDEVVN 67
>XP_005264589
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 99  LSYDEVVN 106
>XP_005264588
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 99  LSYDEVVN 106
>XP_005264587
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 99  LSYDEVVN 106
>XP_005264585
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 135 LSYDEVVN 142
>XP_005264584
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 189 LSYDEVVN 196
>XP_005264583
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 191 LSYDEVVN 198
>XP_005264582
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 202 LSYDEVVN 209
>XP_005264581
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD +VN
Sbjct: 202 LSYDEVVN 209
>NP_055527
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTYDRLV 8
            LTY+RL+
Sbjct: 1445 LTYERLL 1451
>NP_006721
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TYDRLV 8
           TYDR+V
Sbjct: 225 TYDRVV 230
>NP_001009932
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TYDRLV 8
           TYDR+V
Sbjct: 225 TYDRVV 230
>NP_001009933
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TYDRLV 8
           TYDR+V
Sbjct: 225 TYDRVV 230
>NP_001009934
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TYDRLV 8
           TYDR+V
Sbjct: 225 TYDRVV 230
>NP_000664
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MLTYDRLV 8
           MLTYD ++
Sbjct: 312 MLTYDPML 319
>NP_001159976
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MLTYDRLV 8
           MLTYD ++
Sbjct: 320 MLTYDPML 327
>NP_001171953
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD L+N
Sbjct: 477 LSYDSLLN 484
>NP_000967
          Length = 165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           +T+D +VN
Sbjct: 104 ITFDEIVN 111
>NP_001431
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MLTYDR 6
           MLTY+R
Sbjct: 667 MLTYER 672
>XP_005277886
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TYDRLV 8
           TYDR+V
Sbjct: 225 TYDRVV 230
>XP_006724302
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD L+N
Sbjct: 477 LSYDSLLN 484
>XP_006721170
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTYDRLV 8
            LTY+RL+
Sbjct: 1445 LTYERLL 1451
>XP_006721169
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTYDRLV 8
            LTY+RL+
Sbjct: 1445 LTYERLL 1451
>XP_005255780
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTYDRLV 8
            LTY+RL+
Sbjct: 1445 LTYERLL 1451
>XP_006716365
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MLTYDR 6
           MLTY+R
Sbjct: 667 MLTYER 672
>NP_037505
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTYDRLVN 9
           L+YD L+N
Sbjct: 477 LSYDSLLN 484
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.143    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,943
Number of extensions: 667
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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