Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     390
NP_001035957                                                           20     390
XP_005276506                                                           20     390
XP_006721991                                                           20     390
XP_006721990                                                           20     390
XP_006721989                                                           20     390
XP_005258041                                                           20     390
XP_006721988                                                           20     390
XP_006721987                                                           20     390
XP_006721986                                                           20     390
XP_005258040                                                           20     390
XP_006721985                                                           20     390
XP_006720412                                                           20     390
NP_055935                                                              17    4312
NP_060833                                                              17    4312
NP_001026879                                                           17    4312
NP_001135920                                                           17    4312
NP_001135921                                                           17    4312
XP_006721159                                                           17    4312
XP_005255675                                                           17    4312
XP_005270007                                                           17    4312
XP_005270006                                                           17    4312
XP_005270005                                                           17    4312
XP_005270004                                                           17    4312
XP_005270003                                                           17    4312
NP_001135923                                                           17    4312
NP_114427                                                              17    4312
NP_001135922                                                           17    4312
NP_001118230                                                           16    5631
XP_006721512                                                           16    5631
XP_006721511                                                           16    5631
NP_001004684                                                           16    5631
NP_001230925                                                           16    7355
NP_001027                                                              16    7355
NP_001139189                                                           15    9605
NP_001167539                                                           15    9605
NP_001123368                                                           15    9605
NP_542775                                                              15    9605
NP_001027025                                                           15    9605
XP_005262286                                                           15    9605
XP_006724781                                                           15    9605
XP_006724780                                                           15    9605
XP_005262283                                                           15    9605
>NP_000258
          Length = 2818

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1569 LSIFYQAG 1576
>NP_001035957
          Length = 2839

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1590 LSIFYQAG 1597
>XP_005276506
          Length = 151

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   LSIFYQAG 9
           LSIFYQAG
Sbjct: 114 LSIFYQAG 121
>XP_006721991
          Length = 1632

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1600 LSIFYQAG 1607
>XP_006721990
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1600 LSIFYQAG 1607
>XP_006721989
          Length = 2823

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1600 LSIFYQAG 1607
>XP_005258041
          Length = 2836

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1569 LSIFYQAG 1576
>XP_006721988
          Length = 2846

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1579 LSIFYQAG 1586
>XP_006721987
          Length = 2849

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1600 LSIFYQAG 1607
>XP_006721986
          Length = 2854

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1587 LSIFYQAG 1594
>XP_005258040
          Length = 2857

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1590 LSIFYQAG 1597
>XP_006721985
          Length = 2867

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    LSIFYQAG 9
            LSIFYQAG
Sbjct: 1600 LSIFYQAG 1607
>XP_006720412
          Length = 128

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  LSIFYQAG 9
          LSIFYQAG
Sbjct: 91 LSIFYQAG 98
>NP_055935
          Length = 4169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SIFYQAG 9
           SIFYQ G
Sbjct: 583 SIFYQQG 589
>NP_060833
          Length = 315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 196 LGLFYEAG 203
>NP_001026879
          Length = 342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 196 LGLFYEAG 203
>NP_001135920
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 187 MLSIFYFA 194
>NP_001135921
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 165 MLSIFYFA 172
>XP_006721159
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 232 MLSIFYFA 239
>XP_005255675
          Length = 573

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 232 MLSIFYFA 239
>XP_005270007
          Length = 232

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 113 LGLFYEAG 120
>XP_005270006
          Length = 241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 196 LGLFYEAG 203
>XP_005270005
          Length = 259

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 113 LGLFYEAG 120
>XP_005270004
          Length = 265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 196 LGLFYEAG 203
>XP_005270003
          Length = 306

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIFYQAG 9
           L +FY+AG
Sbjct: 196 LGLFYEAG 203
>NP_001135923
          Length = 476

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 187 MLSIFYFA 194
>NP_114427
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 187 MLSIFYFA 194
>NP_001135922
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLSIFY A
Sbjct: 114 MLSIFYFA 121
>NP_001118230
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           MLS+FY A
Sbjct: 230 MLSVFYFA 237
>XP_006721512
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  MLSIFYQA 8
          MLS+FY A
Sbjct: 60 MLSVFYFA 67
>XP_006721511
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  MLSIFYQA 8
          MLS+FY A
Sbjct: 79 MLSVFYFA 86
>NP_001004684
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MLSIFYQA 8
           M+S+FY A
Sbjct: 289 MISVFYTA 296
>NP_001230925
          Length = 4865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IFYQAG 9
           IFY+AG
Sbjct: 249 IFYEAG 254
>NP_001027
          Length = 4870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IFYQAG 9
           IFY+AG
Sbjct: 249 IFYEAG 254
>NP_001139189
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5  FYQAG 9
          FYQAG
Sbjct: 26 FYQAG 30
>NP_001167539
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>NP_001123368
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>NP_542775
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>NP_001027025
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LSIFYQA 8
           +S+FYQ+
Sbjct: 142 ISVFYQS 148
>XP_005262286
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>XP_006724781
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>XP_006724780
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
>XP_005262283
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MLSIFYQAG 9
           M+SI+ +AG
Sbjct: 341 MMSIYSEAG 349
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.145    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,184
Number of extensions: 555
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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