Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     869
XP_006716142                                                           19     869
XP_005250088                                                           19     869
XP_006716141                                                           19     869
XP_005250085                                                           19     869
XP_006716140                                                           19     869
XP_005250084                                                           19     869
XP_005250083                                                           19     869
XP_005250082                                                           19     869
NP_937839                                                              18    1935
XP_005247120                                                           18    1935
XP_006713533                                                           18    1935
XP_006713532                                                           18    1935
NP_005807                                                              18    1935
NP_002378                                                              17    3301
NP_001078846                                                           17    3301
XP_005272048                                                           17    3301
XP_006714680                                                           17    3301
NP_115804                                                              17    4312
NP_001009811                                                           17    4312
NP_055799                                                              17    4312
XP_006724772                                                           17    4312
XP_005257233                                                           17    4312
XP_005257231                                                           17    4312
NP_775871                                                              16    5631
NP_001269836                                                           16    7355
NP_001269837                                                           16    7355
NP_001269838                                                           16    7355
NP_006576                                                              16    7355
NP_116321                                                              16    7355
XP_005258102                                                           16    7355
NP_065816                                                              15    9605
NP_061728                                                              15    9605
NP_113683                                                              15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
NP_113684                                                              15    9605
>NP_733751
          Length = 4911

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3436 MVGSEISSS 3444
>XP_006716142
          Length = 4927

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_005250088
          Length = 4928

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_006716141
          Length = 4959

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_005250085
          Length = 4979

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_006716140
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_005250084
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>XP_005250083
          Length = 4982

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3452 MVGSEISSS 3460
>XP_005250082
          Length = 4983

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MLGSEISSS 9
            M+GSEISSS
Sbjct: 3453 MVGSEISSS 3461
>NP_937839
          Length = 585

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   MLGSEISSS 9
           +LGSEISS+
Sbjct: 377 LLGSEISST 385
>XP_005247120
          Length = 419

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   MLGSEISSS 9
           +LGSEISS+
Sbjct: 377 LLGSEISST 385
>XP_006713533
          Length = 568

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   MLGSEISSS 9
           +LGSEISS+
Sbjct: 361 LLGSEISST 369
>XP_006713532
          Length = 584

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   MLGSEISSS 9
           +LGSEISS+
Sbjct: 377 LLGSEISST 385
>NP_005807
          Length = 569

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   MLGSEISSS 9
           +LGSEISS+
Sbjct: 361 LLGSEISST 369
>NP_002378
          Length = 829

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MLGSEISS 8
           +LGSEISS
Sbjct: 346 VLGSEISS 353
>NP_001078846
          Length = 1019

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MLGSEISS 8
           +LGSEISS
Sbjct: 536 VLGSEISS 543
>XP_005272048
          Length = 851

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MLGSEISS 8
           +LGSEISS
Sbjct: 346 VLGSEISS 353
>XP_006714680
          Length = 1002

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   MLGSEISS 8
           +LGSEISS
Sbjct: 497 VLGSEISS 504
>NP_115804
          Length = 1810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LGSEISSS 9
            LG+E+SSS
Sbjct: 1059 LGAEVSSS 1066
>NP_001009811
          Length = 1044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGSE+S+S
Sbjct: 562 LGSEVSTS 569
>NP_055799
          Length = 1080

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGSE+S+S
Sbjct: 562 LGSEVSTS 569
>XP_006724772
          Length = 1605

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LG+E+SSS
Sbjct: 854 LGAEVSSS 861
>XP_005257233
          Length = 1046

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGSE+S+S
Sbjct: 562 LGSEVSTS 569
>XP_005257231
          Length = 1080

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGSE+S+S
Sbjct: 562 LGSEVSTS 569
>NP_775871
          Length = 8384

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LGSEISSS 9
            LGS++SSS
Sbjct: 7791 LGSQLSSS 7798
>NP_001269836
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MLGSEISSS 9
           +LGS ISSS
Sbjct: 188 ILGSGISSS 196
>NP_001269837
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MLGSEISSS 9
           +LGS ISSS
Sbjct: 156 ILGSGISSS 164
>NP_001269838
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MLGSEISSS 9
           +LGS ISSS
Sbjct: 134 ILGSGISSS 142
>NP_006576
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MLGSEISSS 9
           +LGS ISSS
Sbjct: 207 ILGSGISSS 215
>NP_116321
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LGSEISSS 9
           LGS +SSS
Sbjct: 246 LGSSVSSS 253
>XP_005258102
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LGSEISSS 9
           LGS +SSS
Sbjct: 216 LGSSVSSS 223
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>NP_061728
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGS++SS+
Sbjct: 281 LGSDVSST 288
>NP_113683
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGS++SS+
Sbjct: 281 LGSDVSST 288
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MLGSEISSS 9
           M+G  ISSS
Sbjct: 387 MIGQAISSS 395
>NP_113684
          Length = 808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LGSEISSS 9
           LGS++SS+
Sbjct: 281 LGSDVSST 288
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.292    0.109    0.241 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,863
Number of extensions: 764
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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