Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_001275558                                                           18    1935
NP_004431                                                              18    1935
XP_006715432                                                           18    1935
XP_005248726                                                           18    1935
NP_004739                                                              17    4312
NP_001191379                                                           17    4312
NP_065790                                                              17    4312
NP_055833                                                              16    5631
NP_001186871                                                           16    5631
NP_036410                                                              16    5631
XP_005262312                                                           16    5631
XP_006715463                                                           16    5631
XP_006715462                                                           16    5631
XP_006715461                                                           16    5631
XP_006715460                                                           16    5631
XP_006715459                                                           16    5631
XP_006715458                                                           16    5631
XP_006715457                                                           16    5631
XP_006715456                                                           16    5631
NP_036285                                                              16    7355
NP_001193545                                                           16    7355
NP_001193544                                                           16    7355
NP_835260                                                              16    7355
XP_005252919                                                           16    7355
XP_006718239                                                           16    7355
XP_005252918                                                           16    7355
XP_005252917                                                           16    7355
XP_005252915                                                           16    7355
XP_005252914                                                           16    7355
XP_005251896                                                           16    7355
XP_005251895                                                           16    7355
XP_005251894                                                           16    7355
XP_006714523                                                           16    7355
XP_005248329                                                           16    7355
XP_005248328                                                           16    7355
XP_006714522                                                           16    7355
XP_006714521                                                           16    7355
XP_006714520                                                           16    7355
XP_005248327                                                           16    7355
XP_005248326                                                           16    7355
XP_006714519                                                           16    7355
NP_055925                                                              16    7355
NP_059138                                                              15    9605
NP_036450                                                              15    9605
NP_955452                                                              15    9605
XP_005272248                                                           15    9605
XP_006717135                                                           15    9605
XP_006717133                                                           15    9605
XP_006717132                                                           15    9605
XP_005272243                                                           15    9605
XP_005272242                                                           15    9605
XP_006717130                                                           15    9605
XP_005248027                                                           15    9605
XP_006713947                                                           15    9605
XP_006713543                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 2315 MIKKLDASC 2323
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   MIKQLDASC 9
           MIK+LDASC
Sbjct: 967 MIKKLDASC 975
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 1967 MIKKLDASC 1975
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 2309 MIKKLDASC 2317
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 2315 MIKKLDASC 2323
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 2315 MIKKLDASC 2323
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    MIKQLDASC 9
            MIK+LDASC
Sbjct: 2315 MIKKLDASC 2323
>NP_001275558
          Length = 993

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQLDASC 9
           K+LDASC
Sbjct: 621 KELDASC 627
>NP_004431
          Length = 998

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQLDASC 9
           K+LDASC
Sbjct: 626 KELDASC 632
>XP_006715432
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQLDASC 9
           K+LDASC
Sbjct: 238 KELDASC 244
>XP_005248726
          Length = 994

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQLDASC 9
           K+LDASC
Sbjct: 622 KELDASC 628
>NP_004739
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MIKQLDASC 9
           M+K+LD  C
Sbjct: 664 MLKELDTFC 672
>NP_001191379
          Length = 807

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MIKQLDASC 9
           M+K+LD  C
Sbjct: 664 MLKELDTFC 672
>NP_065790
          Length = 757

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MIKQLDASC 9
           M+K+LD  C
Sbjct: 664 MLKELDTFC 672
>NP_055833
          Length = 2465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2122 QMDASC 2127
>NP_001186871
          Length = 2476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2113 QMDASC 2118
>NP_036410
          Length = 347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           KQL ASC
Sbjct: 212 KQLPASC 218
>XP_005262312
          Length = 224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KQLDASC 9
          KQL ASC
Sbjct: 89 KQLPASC 95
>XP_006715463
          Length = 2434

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2122 QMDASC 2127
>XP_006715462
          Length = 2452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2089 QMDASC 2094
>XP_006715461
          Length = 2456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2113 QMDASC 2118
>XP_006715460
          Length = 2465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2122 QMDASC 2127
>XP_006715459
          Length = 2475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2112 QMDASC 2117
>XP_006715458
          Length = 2476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2113 QMDASC 2118
>XP_006715457
          Length = 2485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2122 QMDASC 2127
>XP_006715456
          Length = 2485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    QLDASC 9
            Q+DASC
Sbjct: 2122 QMDASC 2127
>NP_036285
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 67 QLDANC 72
>NP_001193545
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 89 QLDANC 94
>NP_001193544
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 67 QLDANC 72
>NP_835260
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1431 IKELDAS 1437
>XP_005252919
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 67 QLDANC 72
>XP_006718239
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 89 QLDANC 94
>XP_005252918
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 89 QLDANC 94
>XP_005252917
          Length = 300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 67 QLDANC 72
>XP_005252915
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 78 QLDANC 83
>XP_005252914
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  QLDASC 9
          QLDA+C
Sbjct: 89 QLDANC 94
>XP_005251896
          Length = 1063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           KQL+ SC
Sbjct: 223 KQLETSC 229
>XP_005251895
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           KQL+ SC
Sbjct: 223 KQLETSC 229
>XP_005251894
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           KQL+ SC
Sbjct: 223 KQLETSC 229
>XP_006714523
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1100 IKELDAS 1106
>XP_005248329
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1257 IKELDAS 1263
>XP_005248328
          Length = 2699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1257 IKELDAS 1263
>XP_006714522
          Length = 2719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1277 IKELDAS 1283
>XP_006714521
          Length = 2781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1339 IKELDAS 1345
>XP_006714520
          Length = 2802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1360 IKELDAS 1366
>XP_005248327
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1431 IKELDAS 1437
>XP_005248326
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1431 IKELDAS 1437
>XP_006714519
          Length = 2873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    IKQLDAS 8
            IK+LDAS
Sbjct: 1431 IKELDAS 1437
>NP_055925
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           KQL+ SC
Sbjct: 223 KQLETSC 229
>NP_059138
          Length = 1032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IKQLDASC 9
           +++LD SC
Sbjct: 703 LRRLDVSC 710
>NP_036450
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IKQLDASC 9
           +K+L A+C
Sbjct: 372 VKELQAAC 379
>NP_955452
          Length = 2590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IKQLDASC 9
            IK+ DA+C
Sbjct: 2404 IKENDAAC 2411
>XP_005272248
          Length = 1226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 595 RQLQASC 601
>XP_006717135
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 601 RQLQASC 607
>XP_006717133
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 639 RQLQASC 645
>XP_006717132
          Length = 1254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 639 RQLQASC 645
>XP_005272243
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 633 RQLQASC 639
>XP_005272242
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 634 RQLQASC 640
>XP_006717130
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KQLDASC 9
           +QL ASC
Sbjct: 639 RQLQASC 645
>XP_005248027
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IKQLDASC 9
          +K+L A+C
Sbjct: 67 VKELQAAC 74
>XP_006713947
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IKQLDASC 9
           +K+L A+C
Sbjct: 372 VKELQAAC 379
>XP_006713543
          Length = 2591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IKQLDASC 9
            IK+ DA+C
Sbjct: 2405 IKENDAAC 2412
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.130    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 471,716
Number of extensions: 855
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package