Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     390
NP_775790                                                              19     665
XP_005251234                                                           19     665
XP_005251233                                                           19     665
NP_001010852                                                           19     869
NP_001245210                                                           18    1482
NP_000242                                                              18    1482
XP_005264389                                                           18    1482
NP_036564                                                              18    1935
XP_006711735                                                           18    1935
XP_005245698                                                           18    1935
NP_001138887                                                           18    1935
NP_001154803                                                           17    3301
NP_001154802                                                           17    3301
NP_061857                                                              17    3301
XP_005269043                                                           17    3301
XP_006719529                                                           17    3301
XP_005269042                                                           17    3301
XP_005269041                                                           17    3301
XP_005263735                                                           17    3301
NP_002431                                                              17    4312
NP_001420                                                              16    5631
NP_085126                                                              16    5631
NP_001136116                                                           16    5631
XP_006724228                                                           16    5631
XP_005246927                                                           16    5631
XP_005246925                                                           16    5631
XP_006712841                                                           16    5631
XP_005246924                                                           16    5631
XP_006712840                                                           16    5631
NP_001121897                                                           16    7355
NP_001041638                                                           16    7355
NP_036354                                                              16    7355
NP_001041637                                                           16    7355
NP_001041636                                                           16    7355
NP_001041639                                                           16    7355
NP_775862                                                              16    7355
XP_005268859                                                           16    7355
XP_006710715                                                           16    7355
XP_006710714                                                           16    7355
XP_006710713                                                           16    7355
XP_005270942                                                           16    7355
XP_005270941                                                           16    7355
XP_006710712                                                           16    7355
XP_006710711                                                           16    7355
XP_005270938                                                           16    7355
XP_005270937                                                           16    7355
NP_003042                                                              15    9605
NP_001159968                                                           15    9605
NP_001122405                                                           15    9605
NP_001122406                                                           15    9605
NP_001273683                                                           15    9605
NP_597734                                                              15    9605
NP_001252541                                                           15    9605
NP_057368                                                              15    9605
NP_996882                                                              15    9605
NP_054790                                                              15    9605
NP_653318                                                              15    9605
NP_002214                                                              15    9605
NP_958934                                                              15    9605
XP_006723818                                                           15    9605
XP_006723817                                                           15    9605
XP_006723816                                                           15    9605
XP_006723815                                                           15    9605
XP_006723814                                                           15    9605
XP_006723813                                                           15    9605
XP_005260405                                                           15    9605
XP_006719127                                                           15    9605
XP_006713728                                                           15    9605
NP_005536                                                              15    9605
>NP_002430
          Length = 1137

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MIITRPNMG 9
           MIIT PNMG
Sbjct: 892 MIITGPNMG 900
>NP_775790
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  MIITRPNMG 9
          MIITRP++G
Sbjct: 59 MIITRPDIG 67
>XP_005251234
          Length = 317

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  MIITRPNMG 9
          MIITRP++G
Sbjct: 59 MIITRPDIG 67
>XP_005251233
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1  MIITRPNMG 9
          MIITRP++G
Sbjct: 59 MIITRPDIG 67
>NP_001010852
          Length = 327

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  MIITRPNMG 9
          M+ITRP++G
Sbjct: 37 MVITRPDIG 45
>NP_001245210
          Length = 868

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IITRPNMG 9
           IIT PNMG
Sbjct: 600 IITGPNMG 607
>NP_000242
          Length = 934

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IITRPNMG 9
           IIT PNMG
Sbjct: 666 IITGPNMG 673
>XP_005264389
          Length = 921

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   IITRPNMG 9
           IIT PNMG
Sbjct: 666 IITGPNMG 673
>NP_036564
          Length = 1290

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TRPNMG 9
           TRPNMG
Sbjct: 418 TRPNMG 423
>XP_006711735
          Length = 739

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TRPNMG 9
           TRPNMG
Sbjct: 418 TRPNMG 423
>XP_005245698
          Length = 1292

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TRPNMG 9
           TRPNMG
Sbjct: 418 TRPNMG 423
>NP_001138887
          Length = 1291

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TRPNMG 9
           TRPNMG
Sbjct: 418 TRPNMG 423
>NP_001154803
          Length = 703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 440 ITRPNAG 446
>NP_001154802
          Length = 692

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 429 ITRPNAG 435
>NP_061857
          Length = 1049

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 429 ITRPNAG 435
>XP_005269043
          Length = 737

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 117 ITRPNAG 123
>XP_006719529
          Length = 923

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 303 ITRPNAG 309
>XP_005269042
          Length = 969

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 349 ITRPNAG 355
>XP_005269041
          Length = 1049

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           ITRPN G
Sbjct: 429 ITRPNAG 435
>XP_005263735
          Length = 686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MIITRPNM 8
           M+IT PN+
Sbjct: 678 MVITNPNL 685
>NP_002431
          Length = 936

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MIITRPNM 8
           +IIT PNM
Sbjct: 676 LIITGPNM 683
>NP_001420
          Length = 2414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           +T PNMG
Sbjct: 131 LTSPNMG 137
>NP_085126
          Length = 1671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 625 LVLTRPN 631
>NP_001136116
          Length = 1700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 625 LVLTRPN 631
>XP_006724228
          Length = 2388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           +T PNMG
Sbjct: 131 LTSPNMG 137
>XP_005246927
          Length = 1683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 608 LVLTRPN 614
>XP_005246925
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 621 LVLTRPN 627
>XP_006712841
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 650 LVLTRPN 656
>XP_005246924
          Length = 1713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 638 LVLTRPN 644
>XP_006712840
          Length = 1725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           +++TRPN
Sbjct: 650 LVLTRPN 656
>NP_001121897
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 388 LLVQRPNSG 396
>NP_001041638
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 360 LLVQRPNSG 368
>NP_036354
          Length = 546

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 385 LLVQRPNSG 393
>NP_001041637
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 361 LLVQRPNSG 369
>NP_001041636
          Length = 535

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 374 LLVQRPNSG 382
>NP_001041639
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 360 LLVQRPNSG 368
>NP_775862
          Length = 2344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IITRPNMG 9
           I+T PN G
Sbjct: 550 ILTSPNQG 557
>XP_005268859
          Length = 2361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IITRPNMG 9
           I+T PN G
Sbjct: 567 ILTSPNQG 574
>XP_006710715
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 245 LLVQRPNSG 253
>XP_006710714
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 245 LLVQRPNSG 253
>XP_006710713
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 245 LLVQRPNSG 253
>XP_005270942
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 268 LLVQRPNSG 276
>XP_005270941
          Length = 429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 268 LLVQRPNSG 276
>XP_006710712
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 360 LLVQRPNSG 368
>XP_006710711
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 371 LLVQRPNSG 379
>XP_005270938
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 371 LLVQRPNSG 379
>XP_005270937
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   MIITRPNMG 9
           +++ RPN G
Sbjct: 375 LLVQRPNSG 383
>NP_003042
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IITRPNMG 9
           ++ RP+MG
Sbjct: 310 MVARPSMG 317
>NP_001159968
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IITRPNMG 9
           ++ RP+MG
Sbjct: 310 MVARPSMG 317
>NP_001122405
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MIITRPNMG 9
          M+I RP+ G
Sbjct: 82 MLIKRPSSG 90
>NP_001122406
          Length = 1109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MIITRPNMG 9
          M+I RP+ G
Sbjct: 82 MLIKRPSSG 90
>NP_001273683
          Length = 1230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MIITRPNMG 9
          M+I RP+ G
Sbjct: 51 MLIKRPSSG 59
>NP_597734
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MIITRPNMG 9
          M+I RP+ G
Sbjct: 82 MLIKRPSSG 90
>NP_001252541
          Length = 2371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  MIITRPN 7
          ++IT+PN
Sbjct: 80 LLITKPN 86
>NP_057368
          Length = 2376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  MIITRPN 7
          ++IT+PN
Sbjct: 80 LLITKPN 86
>NP_996882
          Length = 1551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  MIITRPN 7
          ++IT+PN
Sbjct: 80 LLITKPN 86
>NP_054790
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1628 VVTMPNAG 1635
>NP_653318
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IITRPNM 8
           I+TRP M
Sbjct: 137 ILTRPGM 143
>NP_002214
          Length = 2701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           ++IT+PN
Sbjct: 496 VVITKPN 502
>NP_958934
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           IT PN+G
Sbjct: 280 ITSPNVG 286
>XP_006723818
          Length = 1975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1628 VVTMPNAG 1635
>XP_006723817
          Length = 2020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1585 VVTMPNAG 1592
>XP_006723816
          Length = 2034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1628 VVTMPNAG 1635
>XP_006723815
          Length = 2051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1616 VVTMPNAG 1623
>XP_006723814
          Length = 2052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1617 VVTMPNAG 1624
>XP_006723813
          Length = 2062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1628 VVTMPNAG 1635
>XP_005260405
          Length = 2063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2    IITRPNMG 9
            ++T PN G
Sbjct: 1628 VVTMPNAG 1635
>XP_006719127
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MIITRPN 7
           ++IT+PN
Sbjct: 496 VVITKPN 502
>XP_006713728
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IITRPNM 8
          I+TRP M
Sbjct: 90 ILTRPGM 96
>NP_005536
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ITRPNMG 9
           IT PN+G
Sbjct: 280 ITSPNVG 286
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.144    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 641,389
Number of extensions: 792
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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