Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_001175                                                              20     509
NP_055907                                                              18    1135
XP_005255242                                                           18    1135
XP_005255241                                                           18    1135
XP_005255240                                                           18    1135
XP_005255239                                                           18    1135
NP_808881                                                              17    2528
NP_060224                                                              17    4312
XP_005249256                                                           17    4312
XP_006715189                                                           17    4312
XP_006715188                                                           17    4312
NP_000060                                                              16    5631
NP_620165                                                              16    5631
NP_001265662                                                           16    5631
NP_473455                                                              16    5631
NP_004299                                                              16    5631
XP_005245535                                                           16    5631
NP_055031                                                              16    7355
NP_004247                                                              16    7355
NP_001136065                                                           16    7355
NP_001136066                                                           16    7355
NP_000284                                                              15    9605
NP_001027005                                                           15    9605
NP_150285                                                              15    9605
NP_001139114                                                           15    9605
NP_055502                                                              15    9605
NP_060898                                                              15    9605
NP_001004127                                                           15    9605
NP_001265546                                                           15    9605
NP_001265545                                                           15    9605
NP_060516                                                              15    9605
NP_004327                                                              15    9605
NP_006728                                                              15    9605
NP_001229796                                                           15    9605
NP_056028                                                              15    9605
NP_065770                                                              15    9605
NP_001230183                                                           15    9605
NP_057321                                                              15    9605
NP_851851                                                              15    9605
NP_001185655                                                           15    9605
XP_005256041                                                           15    9605
XP_005256040                                                           15    9605
XP_006719512                                                           15    9605
XP_005253957                                                           15    9605
XP_006718232                                                           15    9605
XP_005252889                                                           15    9605
XP_006713894                                                           15    9605
XP_006713893                                                           15    9605
XP_006713892                                                           15    9605
XP_005269431                                                           15    9605
XP_006713891                                                           15    9605
XP_006713890                                                           15    9605
NP_060906                                                              15    9605
NP_851852                                                              15    9605
NP_001017526                                                           15    9605
NP_001131031                                                           15    9605
NP_004505                                                              15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2922 GVEGVFRR 2929
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 1574 GVEGVFRR 1581
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2574 GVEGVFRR 2581
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2916 GVEGVFRR 2923
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2922 GVEGVFRR 2929
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2922 GVEGVFRR 2929
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    GVEGVFRR 9
            GVEGVFRR
Sbjct: 2922 GVEGVFRR 2929
>NP_001175
          Length = 2644

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    MGVEGVFRR 9
            MG EG+FRR
Sbjct: 2526 MGTEGLFRR 2534
>NP_055907
          Length = 3661

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    GVEGVFR 8
            GVEGVFR
Sbjct: 2387 GVEGVFR 2393
>XP_005255242
          Length = 3609

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    GVEGVFR 8
            GVEGVFR
Sbjct: 2335 GVEGVFR 2341
>XP_005255241
          Length = 3637

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    GVEGVFR 8
            GVEGVFR
Sbjct: 2363 GVEGVFR 2369
>XP_005255240
          Length = 3663

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    GVEGVFR 8
            GVEGVFR
Sbjct: 2389 GVEGVFR 2395
>XP_005255239
          Length = 3689

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    GVEGVFR 8
            GVEGVFR
Sbjct: 2415 GVEGVFR 2421
>NP_808881
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GVEGVFR 8
           G+EGVFR
Sbjct: 369 GLEGVFR 375
>NP_060224
          Length = 1440

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MGVEGVFRR 9
           +GV+ +FRR
Sbjct: 420 LGVDSLFRR 428
>XP_005249256
          Length = 1054

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  MGVEGVFRR 9
          +GV+ +FRR
Sbjct: 34 LGVDSLFRR 42
>XP_006715189
          Length = 1240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MGVEGVFRR 9
           +GV+ +FRR
Sbjct: 420 LGVDSLFRR 428
>XP_006715188
          Length = 1400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MGVEGVFRR 9
           +GV+ +FRR
Sbjct: 420 LGVDSLFRR 428
>NP_000060
          Length = 1873

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    EGVFRR 9
            EG+FRR
Sbjct: 1595 EGIFRR 1600
>NP_620165
          Length = 266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 119 EGIFRR 124
>NP_001265662
          Length = 668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  EGVFRR 9
          EG+FRR
Sbjct: 56 EGIFRR 61
>NP_473455
          Length = 731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 119 EGIFRR 124
>NP_004299
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 278 EGIFRR 283
>XP_005245535
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    EGVFRR 9
            EG+FRR
Sbjct: 1576 EGIFRR 1581
>NP_055031
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VEGVFRR 9
           +EGVF R
Sbjct: 250 IEGVFER 256
>NP_004247
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MGVEGVFRR 9
           MG+ G+F R
Sbjct: 453 MGLVGIFSR 461
>NP_001136065
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VEGVFRR 9
           +EGVF R
Sbjct: 250 IEGVFER 256
>NP_001136066
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VEGVFRR 9
           +EGVF R
Sbjct: 250 IEGVFER 256
>NP_000284
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           M ++GVFR
Sbjct: 372 MMIDGVFR 379
>NP_001027005
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           M ++GVFR
Sbjct: 365 MMIDGVFR 372
>NP_150285
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           +GVFRR
Sbjct: 206 DGVFRR 211
>NP_001139114
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 417 EGMFRR 422
>NP_055502
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 462 EGMFRR 467
>NP_060898
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VEGVFRR 9
          V+GVF+R
Sbjct: 92 VQGVFQR 98
>NP_001004127
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VEGVFRR 9
           +EG FRR
Sbjct: 113 LEGAFRR 119
>NP_001265546
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 959 EGLFRR 964
>NP_001265545
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    EGVFRR 9
            EG+FRR
Sbjct: 996  EGLFRR 1001
>NP_060516
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MGVEGVFRR 9
           +G EG F+R
Sbjct: 598 VGSEGTFQR 606
>NP_004327
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    EGVFRR 9
            EG+FRR
Sbjct: 1016 EGLFRR 1021
>NP_006728
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVEGVF 7
           G+EGVF
Sbjct: 450 GLEGVF 455
>NP_001229796
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVEGVF 7
           G+EGVF
Sbjct: 433 GLEGVF 438
>NP_056028
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           +GVE VF+
Sbjct: 293 LGVENVFQ 300
>NP_065770
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    GVEGVFR 8
            G EG+FR
Sbjct: 1569 GGEGIFR 1575
>NP_001230183
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           +GVE VF+
Sbjct: 293 LGVENVFQ 300
>NP_057321
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VEGVFRR 9
           +EGV+R+
Sbjct: 541 IEGVYRK 547
>NP_851851
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 350 EGLFRR 355
>NP_001185655
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 228 EGLFRR 233
>XP_005256041
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           M ++GVFR
Sbjct: 365 MMIDGVFR 372
>XP_005256040
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           M ++GVFR
Sbjct: 372 MMIDGVFR 379
>XP_006719512
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VEGVFRR 9
           +EGV+R+
Sbjct: 143 IEGVYRK 149
>XP_005253957
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VEGVFRR 9
           +EGV+R+
Sbjct: 528 IEGVYRK 534
>XP_006718232
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           +GVE VF+
Sbjct: 269 LGVENVFQ 276
>XP_005252889
          Length = 1307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MGVEGVFR 8
           +GVE VF+
Sbjct: 293 LGVENVFQ 300
>XP_006713894
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 310 EGMFRR 315
>XP_006713893
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 310 EGMFRR 315
>XP_006713892
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 417 EGMFRR 422
>XP_005269431
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 477 EGMFRR 482
>XP_006713891
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 462 EGMFRR 467
>XP_006713890
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 477 EGMFRR 482
>NP_060906
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  MGVEGVFR 8
          +G++GV R
Sbjct: 66 LGIQGVIR 73
>NP_851852
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 228 EGLFRR 233
>NP_001017526
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EGVFRR 9
           EG+FRR
Sbjct: 259 EGLFRR 264
>NP_001131031
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VEGVFRR 9
           +EGV+R+
Sbjct: 429 IEGVYRK 435
>NP_004505
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VEGVFRR 9
           V+GVF+R
Sbjct: 123 VDGVFQR 129
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.155    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,374
Number of extensions: 1050
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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