Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001157394                                                           17    2528
NP_001007026                                                           17    4312
NP_004862                                                              17    4312
XP_006726836                                                           17    4312
XP_006723018                                                           17    4312
XP_005258128                                                           17    4312
XP_005258127                                                           17    4312
XP_006717092                                                           17    4312
XP_006717091                                                           17    4312
XP_006717090                                                           17    4312
XP_006710104                                                           17    4312
NP_776190                                                              16    5631
XP_005276302                                                           16    5631
XP_005276301                                                           16    5631
XP_006716433                                                           16    5631
XP_005273633                                                           16    5631
XP_006716432                                                           16    5631
XP_005273632                                                           16    5631
XP_005272367                                                           16    5631
XP_005272366                                                           16    5631
XP_005276014                                                           16    5631
XP_005276013                                                           16    5631
XP_005275994                                                           16    5631
NP_689759                                                              16    5631
NP_112561                                                              16    5631
NP_006791                                                              16    7355
NP_001269103                                                           16    7355
NP_001180199                                                           16    7355
NP_523353                                                              16    7355
NP_001157934                                                           16    7355
XP_005274497                                                           16    7355
XP_006724524                                                           16    7355
NP_001189451                                                           15    9605
NP_001186169                                                           15    9605
NP_849188                                                              15    9605
NP_149417                                                              15    9605
NP_001186168                                                           15    9605
NP_001186166                                                           15    9605
NP_001186167                                                           15    9605
NP_114147                                                              15    9605
NP_703157                                                              15    9605
NP_065810                                                              15    9605
XP_005275664                                                           15    9605
XP_005275531                                                           15    9605
XP_006725998                                                           15    9605
XP_005275359                                                           15    9605
XP_006725910                                                           15    9605
XP_005275236                                                           15    9605
XP_006725801                                                           15    9605
XP_005275100                                                           15    9605
XP_006725800                                                           15    9605
XP_005272946                                                           15    9605
XP_005260150                                                           15    9605
XP_006720684                                                           15    9605
XP_006718461                                                           15    9605
XP_006718460                                                           15    9605
XP_006715267                                                           15    9605
XP_005249460                                                           15    9605
XP_003846618                                                           15    9605
NP_705834                                                              15    9605
>NP_001157394
          Length = 867

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MESHSSTR 8
           +E HSSTR
Sbjct: 848 LEDHSSTR 855
>NP_001007026
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SHSSTRN 9
          SHSSTR+
Sbjct: 38 SHSSTRD 44
>NP_004862
          Length = 250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SHSSTRN 9
          SHSSTR+
Sbjct: 38 SHSSTRD 44
>XP_006726836
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           ESH STR+
Sbjct: 343 ESHPSTRS 350
>XP_006723018
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           ESH STR+
Sbjct: 343 ESHPSTRS 350
>XP_005258128
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SHSSTRN 9
          SHSSTR+
Sbjct: 88 SHSSTRD 94
>XP_005258127
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SHSSTRN 9
          SHSSTR+
Sbjct: 88 SHSSTRD 94
>XP_006717092
          Length = 672

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ESHSSTRN 9
          E HSS+RN
Sbjct: 20 EFHSSSRN 27
>XP_006717091
          Length = 675

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ESHSSTRN 9
          E HSS+RN
Sbjct: 20 EFHSSSRN 27
>XP_006717090
          Length = 737

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ESHSSTRN 9
          E HSS+RN
Sbjct: 20 EFHSSSRN 27
>XP_006710104
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           ESH STR+
Sbjct: 343 ESHPSTRS 350
>NP_776190
          Length = 155

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           E HSST N
Sbjct: 141 EKHSSTPN 148
>XP_005276302
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 145 QTHSSTRH 152
>XP_005276301
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 176 QTHSSTRH 183
>XP_006716433
          Length = 3069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MESHSSTRN 9
            ++SH ST+N
Sbjct: 1792 IDSHLSTKN 1800
>XP_005273633
          Length = 3069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MESHSSTRN 9
            ++SH ST+N
Sbjct: 1792 IDSHLSTKN 1800
>XP_006716432
          Length = 3172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MESHSSTRN 9
            ++SH ST+N
Sbjct: 1895 IDSHLSTKN 1903
>XP_005273632
          Length = 3172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MESHSSTRN 9
            ++SH ST+N
Sbjct: 1895 IDSHLSTKN 1903
>XP_005272367
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 145 QTHSSTRH 152
>XP_005272366
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 176 QTHSSTRH 183
>XP_005276014
          Length = 344

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 145 QTHSSTRH 152
>XP_005276013
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESHSSTRN 9
           ++HSSTR+
Sbjct: 176 QTHSSTRH 183
>XP_005275994
          Length = 318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SHSSTR 8
           SHSSTR
Sbjct: 165 SHSSTR 170
>NP_689759
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           E+H  TRN
Sbjct: 321 ETHGDTRN 328
>NP_112561
          Length = 2789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MESHSSTRN 9
            ++SH ST+N
Sbjct: 1512 IDSHLSTKN 1520
>NP_006791
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 343 EAHYSTKN 350
>NP_001269103
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 360 EAHYSTKN 367
>NP_001180199
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 497 EAHYSTKN 504
>NP_523353
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 509 EAHYSTKN 516
>NP_001157934
          Length = 5335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MESHSSTRN 9
           M  HSSTR+
Sbjct: 606 MPVHSSTRS 614
>XP_005274497
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 343 EAHYSTKN 350
>XP_006724524
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ESHSSTRN 9
           E+H ST+N
Sbjct: 360 EAHYSTKN 367
>NP_001189451
          Length = 767

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MESHSSTRN 9
           +ESH  TR+
Sbjct: 451 LESHPRTRS 459
>NP_001186169
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>NP_849188
          Length = 2400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SHSSTRN 9
           SH +TRN
Sbjct: 171 SHRNTRN 177
>NP_149417
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>NP_001186168
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>NP_001186166
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>NP_001186167
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>NP_114147
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MESHSSTR 8
           + SHSST+
Sbjct: 269 LRSHSSTQ 276
>NP_703157
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SHSSTRN 9
           +HS TRN
Sbjct: 231 NHSHTRN 237
>NP_065810
          Length = 4700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    SHSSTRN 9
            +HSST N
Sbjct: 3541 THSSTEN 3547
>XP_005275664
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005275531
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_006725998
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005275359
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_006725910
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005275236
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_006725801
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005275100
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_006725800
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005272946
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005260150
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MESHSSTR 8
           + SHSST+
Sbjct: 269 LRSHSSTQ 276
>XP_006720684
          Length = 4713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    SHSSTRN 9
            +HSST N
Sbjct: 3554 THSSTEN 3560
>XP_006718461
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   MESHSSTR 8
           MES  STR
Sbjct: 798 MESEDSTR 805
>XP_006718460
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   MESHSSTR 8
           MES  STR
Sbjct: 943 MESEDSTR 950
>XP_006715267
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_005249460
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ESHSSTRN 9
           ESH  TR+
Sbjct: 198 ESHGETRS 205
>XP_003846618
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SHSSTRN 9
           +HS TRN
Sbjct: 231 NHSHTRN 237
>NP_705834
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MESHSST 7
           MES+SST
Sbjct: 178 MESNSST 184
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.292   0.0961    0.239 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 606,034
Number of extensions: 902
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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