Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           18    1935
NP_060785                                                              18    1935
NP_361014                                                              18    1935
NP_694574                                                              17    2528
XP_005256319                                                           17    2528
XP_006721414                                                           17    2528
NP_001073936                                                           16    5631
NP_000005                                                              16    5631
NP_001036083                                                           16    5631
NP_005475                                                              16    5631
XP_006726604                                                           16    5631
XP_006726603                                                           16    5631
XP_006725215                                                           16    5631
XP_005267304                                                           16    5631
XP_006719240                                                           16    5631
XP_006719237                                                           16    5631
XP_006719119                                                           16    5631
NP_892006                                                              16    7355
NP_149062                                                              16    7355
NP_877398                                                              16    7355
NP_056007                                                              16    7355
NP_001093900                                                           16    7355
NP_001406                                                              16    7355
XP_005260738                                                           16    7355
XP_006723618                                                           16    7355
XP_006715488                                                           16    7355
XP_006715487                                                           16    7355
XP_006715486                                                           16    7355
XP_006715485                                                           16    7355
XP_006715484                                                           16    7355
XP_006715483                                                           16    7355
XP_006715482                                                           16    7355
XP_006715481                                                           16    7355
XP_006715480                                                           16    7355
XP_006715479                                                           16    7355
XP_006715478                                                           16    7355
XP_006715477                                                           16    7355
XP_006715476                                                           16    7355
XP_006715475                                                           16    7355
XP_006715474                                                           16    7355
XP_006715473                                                           16    7355
XP_006715472                                                           16    7355
XP_006715471                                                           16    7355
XP_006715470                                                           16    7355
XP_006714348                                                           16    7355
XP_006714347                                                           16    7355
NP_001093896                                                           16    7355
NP_001093898                                                           16    7355
NP_066982                                                              16    7355
NP_001093897                                                           16    7355
NP_001093899                                                           16    7355
NP_002855                                                              15    9605
NP_065831                                                              15    9605
NP_061180                                                              15    9605
NP_003787                                                              15    9605
NP_001239570                                                           15    9605
XP_005259420                                                           15    9605
XP_005259419                                                           15    9605
>NP_001013433
          Length = 589

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MELKYNILV 9
           MELK NILV
Sbjct: 469 MELKDNILV 477
>NP_060785
          Length = 627

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MELKYNILV 9
           MELK NILV
Sbjct: 507 MELKDNILV 515
>NP_361014
          Length = 707

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MELKYNILV 9
           MELK NILV
Sbjct: 587 MELKDNILV 595
>NP_694574
          Length = 896

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ELKYNILV 9
           E++YNILV
Sbjct: 344 EMEYNILV 351
>XP_005256319
          Length = 678

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ELKYNILV 9
           E++YNILV
Sbjct: 344 EMEYNILV 351
>XP_006721414
          Length = 810

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ELKYNILV 9
           E++YNILV
Sbjct: 258 EMEYNILV 265
>NP_001073936
          Length = 1848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    MELKYNI 7
            M+L+YNI
Sbjct: 1710 MQLRYNI 1716
>NP_000005
          Length = 1474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LKYNIL 8
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>NP_001036083
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MELKYN 6
           ME+KYN
Sbjct: 243 MEMKYN 248
>NP_005475
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MELKYN 6
           ME+KYN
Sbjct: 256 MEMKYN 261
>XP_006726604
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKYNILV 9
           LKYN+L+
Sbjct: 107 LKYNVLL 113
>XP_006726603
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LKYNILV 9
            LKYN+L+
Sbjct: 1125 LKYNVLL 1131
>XP_006725215
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LKYNILV 9
            LKYN+L+
Sbjct: 1125 LKYNVLL 1131
>XP_005267304
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MELKYN 6
           ME+KYN
Sbjct: 256 MEMKYN 261
>XP_006719240
          Length = 113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LKYNILV 9
          LKYN+L+
Sbjct: 21 LKYNVLL 27
>XP_006719237
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LKYNILV 9
            LKYN+L+
Sbjct: 1124 LKYNVLL 1130
>XP_006719119
          Length = 1512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    LKYNIL 8
            LKYNIL
Sbjct: 1328 LKYNIL 1333
>NP_892006
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>NP_149062
          Length = 8749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>NP_877398
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MELKYNILV 9
           M+L Y ILV
Sbjct: 456 MDLMYKILV 464
>NP_056007
          Length = 1216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MELKYNILV 9
           M+L Y ILV
Sbjct: 456 MDLMYKILV 464
>NP_001093900
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 459 EIKYNSMV 466
>NP_001406
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           +LKYNI V
Sbjct: 227 QLKYNIEV 234
>XP_005260738
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MELKYNILV 9
           M+L Y ILV
Sbjct: 456 MDLMYKILV 464
>XP_006723618
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   MELKYNILV 9
           M+L Y ILV
Sbjct: 456 MDLMYKILV 464
>XP_006715488
          Length = 8721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715487
          Length = 8744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715486
          Length = 8758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715485
          Length = 8793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715484
          Length = 8794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715483
          Length = 8795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715482
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>XP_006715481
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 466 LELKYRLL 473
>XP_006715480
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715479
          Length = 8804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715478
          Length = 8809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715477
          Length = 8822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 489 LELKYRLL 496
>XP_006715476
          Length = 8823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715475
          Length = 8827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715474
          Length = 8829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 496 LELKYRLL 503
>XP_006715473
          Length = 8832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715472
          Length = 8839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 506 LELKYRLL 513
>XP_006715471
          Length = 8842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006715470
          Length = 8846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           +ELKY +L
Sbjct: 513 LELKYRLL 520
>XP_006714348
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 421 EIKYNSMV 428
>XP_006714347
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 470 EIKYNSMV 477
>NP_001093896
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 551 EIKYNSMV 558
>NP_001093898
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 502 EIKYNSMV 509
>NP_066982
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 550 EIKYNSMV 557
>NP_001093897
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 550 EIKYNSMV 557
>NP_001093899
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELKYNILV 9
           E+KYN +V
Sbjct: 501 EIKYNSMV 508
>NP_002855
          Length = 1482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    LKYNIL 8
            +KYNIL
Sbjct: 1334 MKYNIL 1339
>NP_065831
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MELKYNI 7
           ++LKYN+
Sbjct: 770 LDLKYNL 776
>NP_061180
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MELKYNIL 8
           MEL++N L
Sbjct: 164 MELRFNTL 171
>NP_003787
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ELKYNILV 9
          +L YNI+V
Sbjct: 71 KLSYNIMV 78
>NP_001239570
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ELKYNILV 9
          +L YNI+V
Sbjct: 53 KLSYNIMV 60
>XP_005259420
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ELKYNILV 9
          +L YNI+V
Sbjct: 71 KLSYNIMV 78
>XP_005259419
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ELKYNILV 9
          +L YNI+V
Sbjct: 53 KLSYNIMV 60
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.146    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 495,090
Number of extensions: 782
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package