Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444284                                                              17    3301
XP_006718716                                                           17    3301
NP_000450                                                              16    5631
NP_001277006                                                           16    5631
XP_005251620                                                           16    5631
XP_005251618                                                           16    5631
NP_277053                                                              16    7355
XP_006724633                                                           16    7355
XP_005272755                                                           16    7355
XP_006724632                                                           16    7355
XP_005272754                                                           16    7355
XP_005272753                                                           16    7355
XP_005272752                                                           16    7355
XP_005272751                                                           16    7355
XP_005268276                                                           15    9605
NP_004265                                                              15    9605

>NP_444284
          Length = 295

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MELILVNVL 9
           MEL+LVN L
Sbjct: 140 MELLLVNKL 148



>XP_006718716
          Length = 303

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   MELILVNVL 9
           MEL+LVN L
Sbjct: 148 MELLLVNKL 156



>NP_000450
          Length = 1124

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MELILVNVL 9
          M+LIL+N L
Sbjct: 24 MDLILINSL 32



>NP_001277006
          Length = 1081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MELILVNVL 9
          M+LIL+N L
Sbjct: 24 MDLILINSL 32



>XP_005251620
          Length = 1080

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MELILVNVL 9
          M+LIL+N L
Sbjct: 24 MDLILINSL 32



>XP_005251618
          Length = 1123

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  MELILVNVL 9
          M+LIL+N L
Sbjct: 24 MDLILINSL 32



>NP_277053
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 384 LVLVNVL 390



>XP_006724633
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 333 LVLVNVL 339



>XP_005272755
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 384 LVLVNVL 390



>XP_006724632
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 384 LVLVNVL 390



>XP_005272754
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 390 LVLVNVL 396



>XP_005272753
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 431 LVLVNVL 437



>XP_005272752
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 431 LVLVNVL 437



>XP_005272751
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LILVNVL 9
           L+LVNVL
Sbjct: 431 LVLVNVL 437



>XP_005268276
          Length = 2320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MELILVNV 8
            M+LI+VN+
Sbjct: 1164 MQLIIVNL 1171



>NP_004265
          Length = 2319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MELILVNV 8
            M+LI+VN+
Sbjct: 1163 MQLIIVNL 1170



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.155    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 369,393
Number of extensions: 466
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)