Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     509
NP_001091680                                                           20     509
NP_001091679                                                           20     509
XP_006713048                                                           20     509
XP_006713047                                                           20     509
XP_006713046                                                           20     509
XP_005264943                                                           20     509
NP_055068                                                              17    3301
NP_001156750                                                           17    3301
NP_001156751                                                           17    3301
NP_073728                                                              17    3301
XP_006724788                                                           17    3301
XP_005255358                                                           17    3301
XP_005255357                                                           17    3301
XP_005255356                                                           17    3301
XP_005255355                                                           17    3301
XP_006712887                                                           17    3301
XP_005246168                                                           17    3301
NP_001138483                                                           17    3301
NP_208384                                                              16    5631
NP_001032412                                                           16    5631
NP_002421                                                              16    5631
NP_859070                                                              16    7355
NP_001128119                                                           16    7355
NP_036538                                                              16    7355
NP_113656                                                              16    7355
NP_001017440                                                           16    7355
NP_940997                                                              16    7355
XP_006719268                                                           16    7355
XP_005268650                                                           16    7355
XP_006716209                                                           16    7355
XP_006713972                                                           16    7355
XP_006713971                                                           16    7355
XP_005245884                                                           16    7355
XP_005245882                                                           16    7355
XP_006710614                                                           16    7355
XP_005245881                                                           16    7355
XP_005245880                                                           16    7355
XP_006710613                                                           16    7355
XP_005245879                                                           16    7355
NP_277055                                                              16    7355
NP_079317                                                              16    7355
NP_001185761                                                           15    9605
NP_001185763                                                           15    9605
NP_003098                                                              15    9605
NP_055459                                                              15    9605
NP_065933                                                              15    9605
NP_001001794                                                           15    9605
XP_006726410                                                           15    9605
XP_005261972                                                           15    9605
XP_005261971                                                           15    9605
XP_006711719                                                           15    9605
XP_006711718                                                           15    9605
XP_006711717                                                           15    9605
XP_006711716                                                           15    9605
XP_006711715                                                           15    9605
XP_006711714                                                           15    9605
XP_006711713                                                           15    9605
XP_006711712                                                           15    9605
XP_006711711                                                           15    9605
XP_006711710                                                           15    9605
XP_006711709                                                           15    9605
XP_005277503                                                           15    9605
XP_005273038                                                           15    9605
XP_006711708                                                           15    9605
XP_005277500                                                           15    9605
XP_006711707                                                           15    9605
XP_005277499                                                           15    9605
XP_006711706                                                           15    9605
XP_006711705                                                           15    9605
XP_006711164                                                           15    9605
XP_006710140                                                           15    9605
NP_705843                                                              15    9605
>NP_001895
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MELGMAMEP 9
          MEL MAMEP
Sbjct: 8  MELDMAMEP 16
>NP_001091680
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MELGMAMEP 9
          MEL MAMEP
Sbjct: 8  MELDMAMEP 16
>NP_001091679
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MELGMAMEP 9
          MEL MAMEP
Sbjct: 8  MELDMAMEP 16
>XP_006713048
          Length = 720

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MELGMAMEP 9
          MEL MAMEP
Sbjct: 8  MELDMAMEP 16
>XP_006713047
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1 MELGMAMEP 9
         MEL MAMEP
Sbjct: 1 MELDMAMEP 9
>XP_006713046
          Length = 774

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1 MELGMAMEP 9
         MEL MAMEP
Sbjct: 1 MELDMAMEP 9
>XP_005264943
          Length = 781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MELGMAMEP 9
          MEL MAMEP
Sbjct: 8  MELDMAMEP 16
>NP_055068
          Length = 2725

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MELGMAMEP 9
            ME+G++ EP
Sbjct: 1734 MEIGLSSEP 1742
>NP_001156750
          Length = 2732

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MELGMAMEP 9
            ME+G++ EP
Sbjct: 1741 MEIGLSSEP 1749
>NP_001156751
          Length = 2731

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MELGMAMEP 9
            ME+G++ EP
Sbjct: 1740 MEIGLSSEP 1748
>NP_073728
          Length = 1255

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ELGMAMEP 9
          ELGM +EP
Sbjct: 64 ELGMLVEP 71
>XP_006724788
          Length = 2570

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MELGMAMEP 9
            ME+G++ EP
Sbjct: 1579 MEIGLSSEP 1587
>XP_005255358
          Length = 1086

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MELGMAMEP 9
           +ELG+ +EP
Sbjct: 338 LELGLELEP 346
>XP_005255357
          Length = 1112

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MELGMAMEP 9
           +ELG+ +EP
Sbjct: 309 LELGLELEP 317
>XP_005255356
          Length = 1114

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MELGMAMEP 9
           +ELG+ +EP
Sbjct: 311 LELGLELEP 319
>XP_005255355
          Length = 1121

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MELGMAMEP 9
           +ELG+ +EP
Sbjct: 338 LELGLELEP 346
>XP_006712887
          Length = 1255

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ELGMAMEP 9
          ELGM +EP
Sbjct: 64 ELGMLVEP 71
>XP_005246168
          Length = 1255

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ELGMAMEP 9
          ELGM +EP
Sbjct: 64 ELGMLVEP 71
>NP_001138483
          Length = 1141

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MELGMAMEP 9
           +ELG+ +EP
Sbjct: 338 LELGLELEP 346
>NP_208384
          Length = 2080

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ELGMAMEP 9
            E GMA EP
Sbjct: 1792 EAGMATEP 1799
>NP_001032412
          Length = 2649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ELGMAMEP 9
            E GMA EP
Sbjct: 2361 EAGMATEP 2368
>NP_002421
          Length = 1320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LGMAMEP 9
          LGM MEP
Sbjct: 61 LGMNMEP 67
>NP_859070
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>NP_001128119
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LGMAMEP 9
           LG+A+EP
Sbjct: 737 LGLAIEP 743
>NP_036538
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ELGMAMEP 9
           E+G+++EP
Sbjct: 319 EVGLSLEP 326
>NP_113656
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ELGMAM 7
           ELGMAM
Sbjct: 102 ELGMAM 107
>NP_001017440
          Length = 219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ELGMAM 7
          ELGMAM
Sbjct: 60 ELGMAM 65
>NP_940997
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LGMAMEP 9
           LG+A+EP
Sbjct: 653 LGLAIEP 659
>XP_006719268
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ELGMAMEP 9
           E+G+++EP
Sbjct: 319 EVGLSLEP 326
>XP_005268650
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ELGMAMEP 9
           E+G+++EP
Sbjct: 319 EVGLSLEP 326
>XP_006716209
          Length = 134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  ELGMAM 7
          ELGMAM
Sbjct: 60 ELGMAM 65
>XP_006713972
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LGMAMEP 9
           LG+A+EP
Sbjct: 674 LGLAIEP 680
>XP_006713971
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LGMAMEP 9
           LG+A+EP
Sbjct: 758 LGLAIEP 764
>XP_005245884
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 279 MELGNALE 286
>XP_005245882
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>XP_006710614
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>XP_005245881
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>XP_005245880
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>XP_006710613
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>XP_005245879
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MELGMAME 8
           MELG A+E
Sbjct: 319 MELGNALE 326
>NP_277055
          Length = 106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ELGMAMEP 9
          +LG A+EP
Sbjct: 4  DLGAALEP 11
>NP_079317
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GMAMEP 9
          GMA+EP
Sbjct: 43 GMALEP 48
>NP_001185761
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1688 IELGRILEP 1696
>NP_001185763
          Length = 2362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1794 IELGRILEP 1802
>NP_003098
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MELGMAMEP 9
          +ELG+A  P
Sbjct: 26 LELGIASSP 34
>NP_055459
          Length = 2346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1794 IELGRILEP 1802
>NP_065933
          Length = 1284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GMAMEP 9
           G+AMEP
Sbjct: 861 GVAMEP 866
>NP_001001794
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MELGMAME 8
          +ELG A+E
Sbjct: 52 LELGQALE 59
>XP_006726410
          Length = 2087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1535 IELGRILEP 1543
>XP_005261972
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MELGMAME 8
          +ELG A+E
Sbjct: 52 LELGQALE 59
>XP_005261971
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MELGMAME 8
          +ELG A+E
Sbjct: 52 LELGQALE 59
>XP_006711719
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1750 IELGRILEP 1758
>XP_006711718
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   MELGMAMEP 9
           +ELG  +EP
Sbjct: 801 IELGRILEP 809
>XP_006711717
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1750 IELGRILEP 1758
>XP_006711716
          Length = 2411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1859 IELGRILEP 1867
>XP_006711715
          Length = 2428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1793 IELGRILEP 1801
>XP_006711714
          Length = 2429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1794 IELGRILEP 1802
>XP_006711713
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1797 IELGRILEP 1805
>XP_006711712
          Length = 2473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_006711711
          Length = 2482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1847 IELGRILEP 1855
>XP_006711710
          Length = 2494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1859 IELGRILEP 1867
>XP_006711709
          Length = 2495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1860 IELGRILEP 1868
>XP_005277503
          Length = 2498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_005273038
          Length = 2509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_006711708
          Length = 2512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_005277500
          Length = 2525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_006711707
          Length = 2553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_005277499
          Length = 2561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_006711706
          Length = 2591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1956 IELGRILEP 1964
>XP_006711705
          Length = 2592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1957 IELGRILEP 1965
>XP_006711164
          Length = 2087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MELGMAMEP 9
            +ELG  +EP
Sbjct: 1535 IELGRILEP 1543
>XP_006710140
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MELGMAMEP 9
          +ELG  +EP
Sbjct: 47 IELGRILEP 55
>NP_705843
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ELGMAMEP 9
           +LG A+EP
Sbjct: 149 DLGPALEP 156
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.130    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 480,971
Number of extensions: 824
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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