Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     665
NP_653080                                                              19     665
XP_005267292                                                           19     665
XP_005267291                                                           19     665
XP_005267290                                                           19     665
NP_067002                                                              17    3301
NP_056503                                                              17    3301
XP_005245441                                                           17    3301
XP_005245439                                                           17    3301
XP_005245440                                                           17    3301
XP_005245438                                                           17    3301
NP_005145                                                              17    4312
NP_001122082                                                           17    4312
NP_001269978                                                           17    4312
XP_006720825                                                           17    4312
XP_006720824                                                           17    4312
NP_114147                                                              16    5631
XP_005260150                                                           16    5631
NP_001189472                                                           16    7355
NP_853530                                                              16    7355
NP_037385                                                              16    7355
NP_001018067                                                           16    7355
NP_056965                                                              16    7355
XP_006718243                                                           16    7355
XP_006718242                                                           16    7355
XP_006718241                                                           16    7355
XP_006718240                                                           16    7355
XP_006715919                                                           16    7355
XP_006715917                                                           16    7355
XP_005250208                                                           16    7355
XP_005250207                                                           16    7355
NP_005912                                                              15    9605
NP_689637                                                              15    9605
NP_036222                                                              15    9605
NP_443070                                                              15    9605
NP_055605                                                              15    9605
NP_001257870                                                           15    9605
NP_001269211                                                           15    9605
NP_112600                                                              15    9605
XP_005262298                                                           15    9605
XP_005248577                                                           15    9605
XP_005248576                                                           15    9605
XP_006710603                                                           15    9605
XP_006710602                                                           15    9605
XP_006710600                                                           15    9605
XP_005270757                                                           15    9605
XP_006710599                                                           15    9605
XP_006710598                                                           15    9605
XP_006710597                                                           15    9605
XP_006710596                                                           15    9605
XP_006710595                                                           15    9605
XP_006710594                                                           15    9605
XP_006710593                                                           15    9605
XP_006710592                                                           15    9605
XP_006710591                                                           15    9605
XP_006710590                                                           15    9605
XP_006710589                                                           15    9605
XP_006710588                                                           15    9605
XP_006710587                                                           15    9605
XP_006710586                                                           15    9605
XP_006710585                                                           15    9605
XP_005270755                                                           15    9605
XP_006710584                                                           15    9605
XP_005270754                                                           15    9605
XP_005270753                                                           15    9605
XP_006710583                                                           15    9605
XP_005270752                                                           15    9605
XP_006710582                                                           15    9605
XP_005270751                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           EKMEAQQA
Sbjct: 858 EKMEAQQA 865
>NP_653080
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           EKMEAQQA
Sbjct: 760 EKMEAQQA 767
>XP_005267292
          Length = 1677

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           EKMEAQQA
Sbjct: 753 EKMEAQQA 760
>XP_005267291
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           EKMEAQQA
Sbjct: 760 EKMEAQQA 767
>XP_005267290
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           EKMEAQQA
Sbjct: 858 EKMEAQQA 865
>NP_067002
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           MEKM  QQA
Sbjct: 463 MEKMAEQQA 471
>NP_056503
          Length = 1060

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           E+M+AQQA
Sbjct: 720 ERMQAQQA 727
>XP_005245441
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           MEKM  QQA
Sbjct: 463 MEKMAEQQA 471
>XP_005245439
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           MEKM  QQA
Sbjct: 464 MEKMAEQQA 472
>XP_005245440
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           MEKM  QQA
Sbjct: 464 MEKMAEQQA 472
>XP_005245438
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           MEKM  QQA
Sbjct: 464 MEKMAEQQA 472
>NP_005145
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           MEK E++QA
Sbjct: 525 MEKKESEQA 533
>NP_001122082
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           MEK E++QA
Sbjct: 525 MEKKESEQA 533
>NP_001269978
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           MEK E++QA
Sbjct: 448 MEKKESEQA 456
>XP_006720825
          Length = 1089

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           MEK E++QA
Sbjct: 525 MEKKESEQA 533
>XP_006720824
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           MEK E++QA
Sbjct: 525 MEKKESEQA 533
>NP_114147
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           M  MEAQQA
Sbjct: 665 MALMEAQQA 673
>XP_005260150
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   MEKMEAQQA 9
           M  MEAQQA
Sbjct: 665 MALMEAQQA 673
>NP_001189472
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 727 EMEAQQA 733
>NP_853530
          Length = 1505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 716 EMEAQQA 722
>NP_037385
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  MEKMEAQQA 9
          +E+MEA++A
Sbjct: 69 VEEMEAEEA 77
>NP_001018067
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  MEKMEAQQA 9
          +E+MEA++A
Sbjct: 69 VEEMEAEEA 77
>NP_056965
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  MEKMEAQQA 9
          +E+MEA++A
Sbjct: 69 VEEMEAEEA 77
>XP_006718243
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MEKMEAQQA 9
           +E+MEA++A
Sbjct: 132 VEEMEAEEA 140
>XP_006718242
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MEKMEAQQA 9
           +E+MEA++A
Sbjct: 132 VEEMEAEEA 140
>XP_006718241
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  MEKMEAQQA 9
          +E+MEA++A
Sbjct: 69 VEEMEAEEA 77
>XP_006718240
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   MEKMEAQQA 9
           +E+MEA++A
Sbjct: 132 VEEMEAEEA 140
>XP_006715919
          Length = 1494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 705 EMEAQQA 711
>XP_006715917
          Length = 1583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 794 EMEAQQA 800
>XP_005250208
          Length = 1603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 814 EMEAQQA 820
>XP_005250207
          Length = 1604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KMEAQQA 9
           +MEAQQA
Sbjct: 815 EMEAQQA 821
>NP_005912
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKMEAQQ 8
            EKMEA++
Sbjct: 1179 EKMEAEE 1185
>NP_689637
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           E++EAQ+A
Sbjct: 576 EQLEAQEA 583
>NP_036222
          Length = 5430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 2987 LEKLRAQQ 2994
>NP_443070
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   MEKMEAQ 7
           +EKM+AQ
Sbjct: 394 LEKMQAQ 400
>NP_055605
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           +EK+E Q+A
Sbjct: 557 LEKIEKQEA 565
>NP_001257870
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           +EK+E Q+A
Sbjct: 557 LEKIEKQEA 565
>NP_001269211
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   MEKMEAQQA 9
           +EK+E Q+A
Sbjct: 515 LEKIEKQEA 523
>NP_112600
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EKMEAQQ 8
           +K+EAQQ
Sbjct: 307 QKLEAQQ 313
>XP_005262298
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EKMEAQQA 9
           E++EAQ+A
Sbjct: 299 EQLEAQEA 306
>XP_005248577
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKMEAQQ 8
            EKMEA++
Sbjct: 1016 EKMEAEE 1022
>XP_005248576
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    EKMEAQQ 8
            EKMEA++
Sbjct: 1042 EKMEAEE 1048
>XP_006710603
          Length = 5324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 2987 LEKLRAQQ 2994
>XP_006710602
          Length = 7391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5054 LEKLRAQQ 5061
>XP_006710600
          Length = 5384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 2987 LEKLRAQQ 2994
>XP_005270757
          Length = 5460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 3126 LEKLRAQQ 3133
>XP_006710599
          Length = 5656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 3147 LEKLRAQQ 3154
>XP_006710598
          Length = 7553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5044 LEKLRAQQ 5051
>XP_006710597
          Length = 7451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5054 LEKLRAQQ 5061
>XP_006710596
          Length = 7512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5003 LEKLRAQQ 5010
>XP_006710595
          Length = 7526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5017 LEKLRAQQ 5024
>XP_006710594
          Length = 7528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5019 LEKLRAQQ 5026
>XP_006710593
          Length = 7539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5030 LEKLRAQQ 5037
>XP_006710592
          Length = 7544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5035 LEKLRAQQ 5042
>XP_006710591
          Length = 7558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5049 LEKLRAQQ 5056
>XP_006710590
          Length = 7563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5054 LEKLRAQQ 5061
>XP_006710589
          Length = 7595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5086 LEKLRAQQ 5093
>XP_006710588
          Length = 7614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_006710587
          Length = 7645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5136 LEKLRAQQ 5143
>XP_006710586
          Length = 7645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_006710585
          Length = 7657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_005270755
          Length = 7663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_006710584
          Length = 7686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_005270754
          Length = 7694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_005270753
          Length = 7700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_006710583
          Length = 7702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5193 LEKLRAQQ 5200
>XP_005270752
          Length = 7717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_006710582
          Length = 7720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
>XP_005270751
          Length = 7723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    MEKMEAQQ 8
            +EK+ AQQ
Sbjct: 5214 LEKLRAQQ 5221
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.101    0.224 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 449,569
Number of extensions: 810
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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