Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1482
NP_653080                                                              18    1482
XP_005267292                                                           18    1482
XP_005267291                                                           18    1482
XP_005267290                                                           18    1482
NP_997203                                                              17    3301
NP_037528                                                              16    5631
NP_001269970                                                           16    5631
NP_001269971                                                           16    5631
NP_003651                                                              16    5631
XP_005261006                                                           16    5631
XP_006724055                                                           16    5631
XP_006723513                                                           16    5631
NP_057213                                                              16    5631
NP_004841                                                              16    7355
XP_006723786                                                           16    7355
XP_006723783                                                           16    7355
XP_006723781                                                           16    7355
XP_006723780                                                           16    7355
XP_006723779                                                           16    7355
XP_006713311                                                           16    7355
XP_006713310                                                           16    7355
XP_005264819                                                           16    7355
XP_006713309                                                           16    7355
XP_005246247                                                           16    7355
NP_060763                                                              16    7355
NP_078789                                                              15    9605
NP_588616                                                              15    9605
NP_001137160                                                           15    9605
NP_001257863                                                           15    9605
NP_055605                                                              15    9605
NP_001257870                                                           15    9605
NP_001269211                                                           15    9605
NP_006176                                                              15    9605
NP_002069                                                              15    9605
NP_001273490                                                           15    9605
XP_005254204                                                           15    9605
XP_005254202                                                           15    9605
XP_005254201                                                           15    9605
XP_006718633                                                           15    9605
XP_006718632                                                           15    9605
XP_006718631                                                           15    9605
XP_006718630                                                           15    9605
XP_006718629                                                           15    9605
XP_006718628                                                           15    9605
XP_006718627                                                           15    9605
XP_006718626                                                           15    9605
XP_006718625                                                           15    9605
XP_005265541                                                           15    9605
XP_006713398                                                           15    9605
XP_006713397                                                           15    9605
XP_006713396                                                           15    9605
XP_005265132                                                           15    9605
XP_006713173                                                           15    9605
XP_005265130                                                           15    9605
XP_005265129                                                           15    9605
XP_005265127                                                           15    9605
XP_005265126                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEAQ AQKS
Sbjct: 860 MEAQQAQKS 868
>NP_653080
          Length = 1684

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEAQ AQKS
Sbjct: 762 MEAQQAQKS 770
>XP_005267292
          Length = 1677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEAQ AQKS
Sbjct: 755 MEAQQAQKS 763
>XP_005267291
          Length = 1684

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEAQ AQKS
Sbjct: 762 MEAQQAQKS 770
>XP_005267290
          Length = 1782

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEAQ AQKS
Sbjct: 860 MEAQQAQKS 868
>NP_997203
          Length = 288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  MEAQLAQK 8
          MEA++AQK
Sbjct: 51 MEAEMAQK 58
>NP_037528
          Length = 1055

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EAQLAQKS 9
           +AQLAQK+
Sbjct: 704 DAQLAQKA 711
>NP_001269970
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EAQLAQKS 9
           +AQLAQK+
Sbjct: 704 DAQLAQKA 711
>NP_001269971
          Length = 1087

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EAQLAQKS 9
           +AQLAQK+
Sbjct: 704 DAQLAQKA 711
>NP_003651
          Length = 1194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           +EAQLAQ+
Sbjct: 374 IEAQLAQR 381
>XP_005261006
          Length = 721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EAQLAQKS 9
           +AQLAQK+
Sbjct: 300 DAQLAQKA 307
>XP_006724055
          Length = 826

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EAQLAQKS 9
           +AQLAQK+
Sbjct: 405 DAQLAQKA 412
>XP_006723513
          Length = 1185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           +EAQLAQ+
Sbjct: 374 IEAQLAQR 381
>NP_057213
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   MEAQLAQ 7
           MEAQ+AQ
Sbjct: 400 MEAQMAQ 406
>NP_004841
          Length = 1388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MEAQLAQKS 9
            M+AQ+A++S
Sbjct: 1091 MQAQIAEES 1099
>XP_006723786
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEA+L Q+S
Sbjct: 312 MEARLRQRS 320
>XP_006723783
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEA+L Q+S
Sbjct: 367 MEARLRQRS 375
>XP_006723781
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEA+L Q+S
Sbjct: 312 MEARLRQRS 320
>XP_006723780
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEA+L Q+S
Sbjct: 344 MEARLRQRS 352
>XP_006723779
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   MEAQLAQKS 9
           MEA+L Q+S
Sbjct: 367 MEARLRQRS 375
>XP_006713311
          Length = 939

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 894 LEAHLAQK 901
>XP_006713310
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    MEAQLAQK 8
            +EA LAQK
Sbjct: 993  LEAHLAQK 1000
>XP_005264819
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    MEAQLAQK 8
            +EA LAQK
Sbjct: 1106 LEAHLAQK 1113
>XP_006713309
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    MEAQLAQK 8
            +EA LAQK
Sbjct: 1106 LEAHLAQK 1113
>XP_005246247
          Length = 1417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    MEAQLAQKS 9
            M+AQ+A++S
Sbjct: 1091 MQAQIAEES 1099
>NP_060763
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 559 LEAHLAQK 566
>NP_078789
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           M+AQ+A+K
Sbjct: 691 MKAQMAEK 698
>NP_588616
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAQLAQK 8
           EAQLAQ+
Sbjct: 923 EAQLAQE 929
>NP_001137160
          Length = 1054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    EAQLAQK 8
            EAQLAQ+
Sbjct: 1006 EAQLAQE 1012
>NP_001257863
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 529 LEATLAQK 536
>NP_055605
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 529 LEATLAQK 536
>NP_001257870
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 529 LEATLAQK 536
>NP_001269211
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MEAQLAQK 8
           +EA LAQK
Sbjct: 487 LEATLAQK 494
>NP_006176
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>NP_002069
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2108 LQTQLAQKT 2116
>NP_001273490
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1582 LQAQLSQK 1589
>XP_005254204
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAQLAQK 8
           EAQLAQ+
Sbjct: 923 EAQLAQE 929
>XP_005254202
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAQLAQK 8
           EAQLAQ+
Sbjct: 923 EAQLAQE 929
>XP_005254201
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EAQLAQK 8
           EAQLAQ+
Sbjct: 989 EAQLAQE 995
>XP_006718633
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1582 LQAQLSQK 1589
>XP_006718632
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718631
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718630
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718629
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718628
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718627
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718626
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_006718625
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    MEAQLAQK 8
            ++AQL+QK
Sbjct: 1596 LQAQLSQK 1603
>XP_005265541
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           M+AQ+A+K
Sbjct: 691 MKAQMAEK 698
>XP_006713398
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           M+AQ+A+K
Sbjct: 691 MKAQMAEK 698
>XP_006713397
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           M+AQ+A+K
Sbjct: 691 MKAQMAEK 698
>XP_006713396
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   MEAQLAQK 8
           M+AQ+A+K
Sbjct: 691 MKAQMAEK 698
>XP_005265132
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2092 LQTQLAQKT 2100
>XP_006713173
          Length = 2250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2128 LQTQLAQKT 2136
>XP_005265130
          Length = 2252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2130 LQTQLAQKT 2138
>XP_005265129
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2147 LQTQLAQKT 2155
>XP_005265127
          Length = 2283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2163 LQTQLAQKT 2171
>XP_005265126
          Length = 2285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    MEAQLAQKS 9
            ++ QLAQK+
Sbjct: 2163 LQTQLAQKT 2171
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.102    0.221 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 288,455
Number of extensions: 566
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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