Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065871                                                              18    1482
XP_005260528                                                           18    1482
NP_005912                                                              17    2528
XP_005248577                                                           17    2528
XP_005248576                                                           17    2528
NP_001135975                                                           17    3301
XP_005262371                                                           17    3301
NP_001278086                                                           17    4312
NP_001181876                                                           17    4312
NP_937887                                                              17    4312
NP_937884                                                              17    4312
NP_004944                                                              17    4312
NP_001181875                                                           17    4312
NP_937885                                                              17    4312
NP_886553                                                              17    4312
XP_005245231                                                           17    4312
NP_001265616                                                           16    5631
NP_001042                                                              16    5631
XP_006726609                                                           16    5631
XP_005261778                                                           16    5631
XP_006724374                                                           16    5631
XP_006719787                                                           16    5631
XP_006710027                                                           16    5631
NP_079160                                                              16    7355
NP_862826                                                              16    7355
NP_001230679                                                           16    7355
XP_005268132                                                           16    7355
XP_006713095                                                           16    7355
NP_570124                                                              15    9605
NP_071882                                                              15    9605
NP_001136074                                                           15    9605
NP_001136073                                                           15    9605
NP_001035292                                                           15    9605
NP_892010                                                              15    9605
NP_057455                                                              15    9605
NP_068807                                                              15    9605
NP_006801                                                              15    9605
XP_005257823                                                           15    9605
XP_005262827                                                           15    9605
XP_006714170                                                           15    9605
XP_006714169                                                           15    9605
XP_006714168                                                           15    9605
XP_005262826                                                           15    9605
XP_006714167                                                           15    9605
XP_005264540                                                           15    9605
XP_006712138                                                           15    9605
XP_006711443                                                           15    9605
>NP_065871
          Length = 1659

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   CRRLMAIA 9
           CRRLMA++
Sbjct: 901 CRRLMALS 908
>XP_005260528
          Length = 956

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   CRRLMAIA 9
           CRRLMA++
Sbjct: 198 CRRLMALS 205
>NP_005912
          Length = 1512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MCRRLMAIA 9
           M RRLMAIA
Sbjct: 852 MRRRLMAIA 860
>XP_005248577
          Length = 1349

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MCRRLMAIA 9
           M RRLMAIA
Sbjct: 689 MRRRLMAIA 697
>XP_005248576
          Length = 1375

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   MCRRLMAIA 9
           M RRLMAIA
Sbjct: 715 MRRRLMAIA 723
>NP_001135975
          Length = 1103

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MCRRLMAI 8
          +CRRLM +
Sbjct: 76 LCRRLMTL 83
>XP_005262371
          Length = 1107

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MCRRLMAI 8
          +CRRLM +
Sbjct: 76 LCRRLMTL 83
>NP_001278086
          Length = 1559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 778 MCRCLMAL 785
>NP_001181876
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 825 MCRCLMAL 832
>NP_937887
          Length = 1512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 731 MCRCLMAL 738
>NP_937884
          Length = 1599

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 818 MCRCLMAL 825
>NP_004944
          Length = 1404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 623 MCRCLMAL 630
>NP_001181875
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 825 MCRCLMAL 832
>NP_937885
          Length = 1435

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 654 MCRCLMAL 661
>NP_886553
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR LMA+
Sbjct: 819 MCRCLMAL 826
>XP_005245231
          Length = 166

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  MCRRLMAI 8
          +CRR MA+
Sbjct: 10 LCRRKMAV 17
>NP_001265616
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR +MA+
Sbjct: 115 MCRLVMAV 122
>NP_001042
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR +MA+
Sbjct: 115 MCRLVMAV 122
>XP_006726609
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           +CR+LM I
Sbjct: 254 ICRKLMVI 261
>XP_005261778
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR +MA+
Sbjct: 115 MCRLVMAV 122
>XP_006724374
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           MCR +MA+
Sbjct: 115 MCRLVMAV 122
>XP_006719787
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           +CR+LM I
Sbjct: 254 ICRKLMVI 261
>XP_006710027
          Length = 2837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MCRRLMAI 8
           +CR+LM I
Sbjct: 254 ICRKLMVI 261
>NP_079160
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CR LMAI
Sbjct: 179 CRGLMAI 185
>NP_862826
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRRLMA 7
          CRRL+A
Sbjct: 14 CRRLLA 19
>NP_001230679
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRRLMA 7
          CRRL+A
Sbjct: 14 CRRLLA 19
>XP_005268132
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CR LMAI
Sbjct: 179 CRGLMAI 185
>XP_006713095
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RRLMAIA 9
          RRLMA+A
Sbjct: 5  RRLMALA 11
>NP_570124
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   CRRLM 6
           CRRLM
Sbjct: 146 CRRLM 150
>NP_071882
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CRRLMAIA 9
           C R+MA+A
Sbjct: 541 CCRIMALA 548
>NP_001136074
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MCRRLMA 7
           +CRRL++
Sbjct: 142 LCRRLLS 148
>NP_001136073
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MCRRLMA 7
           +CRRL++
Sbjct: 142 LCRRLLS 148
>NP_001035292
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>NP_892010
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MCRRLMA 7
           +CRRL++
Sbjct: 228 LCRRLLS 234
>NP_057455
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  MCRRLMA 7
          +C+RL+A
Sbjct: 18 LCKRLLA 24
>NP_068807
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MCRRLMA 7
           +CRRL++
Sbjct: 156 LCRRLLS 162
>NP_006801
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   MCRRLM 6
           MC+R+M
Sbjct: 184 MCKRMM 189
>XP_005257823
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   MCRRLMA 7
           +CRRL++
Sbjct: 142 LCRRLLS 148
>XP_005262827
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714170
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714169
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714168
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_005262826
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714167
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CRRLMAI 8
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_005264540
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CRRLMAIA 9
           C R+MA+A
Sbjct: 540 CCRIMALA 547
>XP_006712138
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CRRLMAIA 9
           C R+MA+A
Sbjct: 546 CCRIMALA 553
>XP_006711443
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  MCRRLMA 7
          +C+RL+A
Sbjct: 18 LCKRLLA 24
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.360    0.142    0.465 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,009
Number of extensions: 355
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.4 bits)
S2: 28 (15.4 bits)

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