Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              20     299
XP_005251512                                                           20     299
NP_055462                                                              17    3301
NP_001171928                                                           17    3301
NP_001171927                                                           17    3301
XP_006725284                                                           17    3301
XP_006725283                                                           17    3301
XP_006725282                                                           17    3301
XP_006725281                                                           17    3301
XP_006725280                                                           17    3301
XP_006725279                                                           17    3301
XP_006725278                                                           17    3301
XP_005255766                                                           17    3301
XP_006721049                                                           17    3301
XP_005255765                                                           17    3301
XP_005255764                                                           17    3301
XP_005255763                                                           17    3301
XP_005255762                                                           17    3301
XP_005255761                                                           17    3301
NP_003593                                                              17    4312
NP_001268233                                                           17    4312
NP_001128683                                                           17    4312
XP_006716216                                                           17    4312
XP_005250700                                                           17    4312
XP_006716215                                                           17    4312
NP_001171922                                                           16    5631
XP_006719914                                                           16    5631
XP_005266530                                                           16    5631
XP_006719913                                                           16    5631
XP_006719912                                                           16    5631
XP_006719911                                                           16    5631
XP_006719910                                                           16    5631
XP_006719909                                                           16    5631
NP_112567                                                              16    5631
NP_000381                                                              16    7355
NP_005679                                                              16    7355
NP_001018881                                                           16    7355
NP_062823                                                              16    7355
XP_006724678                                                           16    7355
XP_006723348                                                           16    7355
XP_006723347                                                           16    7355
XP_005247116                                                           16    7355
XP_005247115                                                           16    7355
NP_758859                                                              15    9605
NP_005209                                                              15    9605
NP_071900                                                              15    9605
NP_758424                                                              15    9605
NP_061142                                                              15    9605
NP_064627                                                              15    9605
NP_056169                                                              15    9605
NP_443179                                                              15    9605
NP_060697                                                              15    9605
XP_005266703                                                           15    9605
XP_005266019                                                           15    9605
XP_005266018                                                           15    9605
XP_005266017                                                           15    9605
XP_006714965                                                           15    9605
XP_006714964                                                           15    9605
XP_005266016                                                           15    9605
XP_006714316                                                           15    9605
XP_006713327                                                           15    9605
XP_005265385                                                           15    9605
>NP_004963
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MACLMMTEM 9
          MACL MTEM
Sbjct: 3  MACLTMTEM 11
>XP_005251512
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  MACLMMTEM 9
          MACL MTEM
Sbjct: 3  MACLTMTEM 11
>NP_055462
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1354 CLMMTDL 1360
>NP_001171928
          Length = 1739

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1351 CLMMTDL 1357
>NP_001171927
          Length = 1742

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1354 CLMMTDL 1360
>XP_006725284
          Length = 1564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1176 CLMMTDL 1182
>XP_006725283
          Length = 1600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1212 CLMMTDL 1218
>XP_006725282
          Length = 1613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1225 CLMMTDL 1231
>XP_006725281
          Length = 1733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1345 CLMMTDL 1351
>XP_006725280
          Length = 1741

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1353 CLMMTDL 1359
>XP_006725279
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_006725278
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_005255766
          Length = 1564

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1176 CLMMTDL 1182
>XP_006721049
          Length = 1600

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1212 CLMMTDL 1218
>XP_005255765
          Length = 1613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1225 CLMMTDL 1231
>XP_005255764
          Length = 1733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1345 CLMMTDL 1351
>XP_005255763
          Length = 1741

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1353 CLMMTDL 1359
>XP_005255762
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>XP_005255761
          Length = 1743

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CLMMT++
Sbjct: 1355 CLMMTDL 1361
>NP_003593
          Length = 327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 262 ACLLLTE 268
>NP_001268233
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 232 ACLLLTE 238
>NP_001128683
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 257 ACLLLTE 263
>XP_006716216
          Length = 282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 217 ACLLLTE 223
>XP_005250700
          Length = 287

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 222 ACLLLTE 228
>XP_006716215
          Length = 322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ACLMMTE 8
           ACL++TE
Sbjct: 257 ACLLLTE 263
>NP_001171922
          Length = 1619

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 59 CLLMTE 64
>XP_006719914
          Length = 1639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_005266530
          Length = 1643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719913
          Length = 1650

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719912
          Length = 1672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 59 CLLMTE 64
>XP_006719911
          Length = 1688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719910
          Length = 1692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>XP_006719909
          Length = 1692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 79 CLLMTE 84
>NP_112567
          Length = 1623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CLMMTE 8
          CL+MTE
Sbjct: 59 CLLMTE 64
>NP_000381
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MACLMMTE 8
           M+C M+TE
Sbjct: 149 MSCEMLTE 156
>NP_005679
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   MACLMMTEM 9
           + CLM+T++
Sbjct: 183 IVCLMITQL 191
>NP_001018881
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   MACLMMTEM 9
           + CLM+T++
Sbjct: 183 IVCLMITQL 191
>NP_062823
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MACLMM 6
           MACLM+
Sbjct: 166 MACLML 171
>XP_006724678
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   MACLMMTE 8
           M+C M+TE
Sbjct: 128 MSCEMLTE 135
>XP_006723348
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  MACLMM 6
          MACLM+
Sbjct: 37 MACLML 42
>XP_006723347
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   MACLMM 6
           MACLM+
Sbjct: 166 MACLML 171
>XP_005247116
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   MACLMMTEM 9
           + CLM+T++
Sbjct: 183 IVCLMITQL 191
>XP_005247115
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   MACLMMTEM 9
           + CLM+T++
Sbjct: 183 IVCLMITQL 191
>NP_758859
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1299 LECLGLTEM 1307
>NP_005209
          Length = 68

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  CLMMTEM 9
          CL+++EM
Sbjct: 12 CLLLSEM 18
>NP_071900
          Length = 2696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1568 LECLGLTEM 1576
>NP_758424
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    MACLMMTEM 9
            +AC+ +TE+
Sbjct: 1146 LACIAITEI 1154
>NP_061142
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    MACLMMTEM 9
            +AC+ +TE+
Sbjct: 1146 LACIAITEI 1154
>NP_064627
          Length = 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    MACLMMTE 8
            M CL MT+
Sbjct: 1282 MECLRMTD 1289
>NP_056169
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   MACLMMT 7
           M CLM+T
Sbjct: 306 MDCLMLT 312
>NP_443179
          Length = 2170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CL++T+M
Sbjct: 2075 CLLVTDM 2081
>NP_060697
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   CLMMTEM 9
           C+++TEM
Sbjct: 156 CVVLTEM 162
>XP_005266703
          Length = 1501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    CLMMTEM 9
            CL++T+M
Sbjct: 1406 CLLVTDM 1412
>XP_005266019
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  MACLMMTEM 9
          + CL +TEM
Sbjct: 66 LECLGLTEM 74
>XP_005266018
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1299 LECLGLTEM 1307
>XP_005266017
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1299 LECLGLTEM 1307
>XP_006714965
          Length = 2427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1299 LECLGLTEM 1307
>XP_006714964
          Length = 2696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1568 LECLGLTEM 1576
>XP_005266016
          Length = 2696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    MACLMMTEM 9
            + CL +TEM
Sbjct: 1568 LECLGLTEM 1576
>XP_006714316
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  CLMMTEM 9
          C+++TEM
Sbjct: 81 CVVLTEM 87
>XP_006713327
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   MACLMMTE 8
           M CL MT+
Sbjct: 917 MECLRMTD 924
>XP_005265385
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    MACLMMTE 8
            M CL MT+
Sbjct: 1185 MECLRMTD 1192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.125    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 531,691
Number of extensions: 565
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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