Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           19     665
NP_060785                                                              19     665
NP_361014                                                              19     665
NP_001257903                                                           17    4312
NP_001784                                                              17    4312
NP_001275505                                                           17    4312
NP_001093881                                                           17    4312
NP_078857                                                              17    4312
XP_006721269                                                           17    4312
XP_005276150                                                           17    4312
NP_061119                                                              16    5631
NP_613258                                                              16    5631
NP_613075                                                              16    5631
NP_001035248                                                           16    5631
NP_004884                                                              16    5631
XP_005272192                                                           16    5631
XP_005272191                                                           16    5631
XP_005272189                                                           16    5631
NP_000065                                                              16    7355
NP_001129494                                                           16    7355
NP_001275731                                                           16    7355
NP_001040                                                              16    7355
NP_003255                                                              16    7355
NP_064425                                                              16    7355
NP_001001290                                                           16    7355
NP_001136095                                                           16    7355
NP_001136094                                                           16    7355
NP_115873                                                              16    7355
XP_005263250                                                           16    7355
XP_005263252                                                           16    7355
XP_005263253                                                           16    7355
XP_005263254                                                           16    7355
XP_005263251                                                           16    7355
XP_006714032                                                           16    7355
XP_006714031                                                           16    7355
NP_001073121                                                           15    9605
NP_689957                                                              15    9605
NP_821174                                                              15    9605
NP_060340                                                              15    9605
XP_006716564                                                           15    9605
XP_005250826                                                           15    9605
NP_001106                                                              15    9605
NP_659493                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           LVTLESGG
Sbjct: 542 LVTLESGG 549
>NP_060785
          Length = 627

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           LVTLESGG
Sbjct: 580 LVTLESGG 587
>NP_361014
          Length = 707

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           LVTLESGG
Sbjct: 660 LVTLESGG 667
>NP_001257903
          Length = 5121

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVTLESGGV 9
            L T+ESGG+
Sbjct: 3352 LQTIESGGL 3360
>NP_001784
          Length = 829

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VTLESGG 8
          VTLE+GG
Sbjct: 36 VTLEAGG 42
>NP_001275505
          Length = 936

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVTLESGGV 9
           L  LESGGV
Sbjct: 861 LSALESGGV 869
>NP_001093881
          Length = 971

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVTLESGGV 9
           L  LESGGV
Sbjct: 896 LSALESGGV 904
>NP_078857
          Length = 1140

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVTLESGGV 9
            L  LESGGV
Sbjct: 1065 LSALESGGV 1073
>XP_006721269
          Length = 5138

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVTLESGGV 9
            L T+ESGG+
Sbjct: 3369 LQTIESGGL 3377
>XP_005276150
          Length = 156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LVTLESGGV 9
          L T+ESGG+
Sbjct: 88 LQTIESGGL 96
>NP_061119
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>NP_613258
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>NP_613075
          Length = 369

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>NP_001035248
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>NP_004884
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>XP_005272192
          Length = 198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>XP_005272191
          Length = 199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>XP_005272189
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VT+ SGGV
Sbjct: 98  VTIASGGV 105
>NP_000065
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LVTLESG 7
           LVTLE+G
Sbjct: 152 LVTLENG 158
>NP_001129494
          Length = 964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VTLESGG 8
           +TLE GG
Sbjct: 939 ITLEEGG 945
>NP_001275731
          Length = 889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VTLESGG 8
           +TLE GG
Sbjct: 864 ITLEEGG 870
>NP_001040
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LESGGV 9
           LESGGV
Sbjct: 373 LESGGV 378
>NP_003255
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>NP_064425
          Length = 540

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VTL +GG+
Sbjct: 356 VTLSTGGI 363
>NP_001001290
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VTL +GG+
Sbjct: 327 VTLSTGGI 334
>NP_001136095
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           +VTL++GG
Sbjct: 262 VVTLDAGG 269
>NP_001136094
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           +VTL++GG
Sbjct: 223 VVTLDAGG 230
>NP_115873
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVTLESGG 8
           +VTL++GG
Sbjct: 262 VVTLDAGG 269
>XP_005263250
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>XP_005263252
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>XP_005263253
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>XP_005263254
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>XP_005263251
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           L TLE+GG
Sbjct: 525 LKTLEAGG 532
>XP_006714032
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VTL +GG+
Sbjct: 327 VTLSTGGI 334
>XP_006714031
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VTLESGGV 9
           VTL +GG+
Sbjct: 356 VTLSTGGI 363
>NP_001073121
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VTLESGG 8
           VTL++GG
Sbjct: 541 VTLDNGG 547
>NP_689957
          Length = 2213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VTLESGG 8
            VTL++GG
Sbjct: 2054 VTLDNGG 2060
>NP_821174
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           LVT++ GG
Sbjct: 425 LVTVDGGG 432
>NP_060340
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVTLESGG 8
           LVT++ GG
Sbjct: 426 LVTVDGGG 433
>XP_006716564
          Length = 1185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LESGGV 9
           LESGG+
Sbjct: 540 LESGGI 545
>XP_005250826
          Length = 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LESGGV 9
           LESGG+
Sbjct: 540 LESGGI 545
>NP_001106
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LESGGV 9
           LESGG+
Sbjct: 540 LESGGI 545
>NP_659493
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VTLESGGV 9
           ++LESGG+
Sbjct: 100 LSLESGGL 107
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.138    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 589,631
Number of extensions: 654
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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