Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001244163                                                           17    4312
NP_001244166                                                           17    4312
NP_001244159                                                           17    4312
NP_001244160                                                           17    4312
NP_001093392                                                           17    4312
NP_057323                                                              17    4312
XP_006724767                                                           17    4312
XP_006724766                                                           17    4312
XP_006724765                                                           17    4312
XP_006724764                                                           17    4312
XP_006724763                                                           17    4312
XP_006724762                                                           17    4312
XP_006724761                                                           17    4312
XP_006724760                                                           17    4312
XP_006724759                                                           17    4312
XP_006724758                                                           17    4312
XP_006724757                                                           17    4312
XP_006724756                                                           17    4312
XP_005256732                                                           17    4312
XP_006718366                                                           16    5631
XP_005253166                                                           16    5631
NP_004445                                                              16    7355
NP_733751                                                              16    7355
NP_001161437                                                           16    7355
NP_113621                                                              16    7355
NP_689711                                                              16    7355
NP_001182760                                                           16    7355
NP_775934                                                              16    7355
NP_079466                                                              16    7355
NP_001252544                                                           16    7355
XP_006716142                                                           16    7355
XP_005250088                                                           16    7355
XP_006716141                                                           16    7355
XP_005250085                                                           16    7355
XP_006716140                                                           16    7355
XP_005250084                                                           16    7355
XP_005250083                                                           16    7355
XP_005250082                                                           16    7355
XP_006714917                                                           16    7355
XP_006714916                                                           16    7355
XP_006714915                                                           16    7355
XP_006714914                                                           16    7355
XP_006714913                                                           16    7355
XP_006714912                                                           16    7355
XP_006714911                                                           16    7355
XP_006714910                                                           16    7355
XP_006714909                                                           16    7355
XP_006714908                                                           16    7355
XP_006714907                                                           16    7355
XP_006714906                                                           16    7355
XP_006714905                                                           16    7355
XP_006714904                                                           16    7355
XP_005265946                                                           16    7355
XP_006712733                                                           16    7355
XP_006712732                                                           16    7355
XP_006712731                                                           16    7355
XP_006712730                                                           16    7355
XP_006712729                                                           16    7355
XP_006712728                                                           16    7355
XP_006712727                                                           16    7355
XP_006712726                                                           16    7355
XP_006712725                                                           16    7355
XP_006712724                                                           16    7355
XP_005264052                                                           16    7355
XP_006710447                                                           16    7355
XP_006710446                                                           16    7355
XP_006710445                                                           16    7355
XP_005270577                                                           16    7355
NP_003382                                                              15    9605
NP_055616                                                              15    9605
XP_006716172                                                           15    9605
XP_006711879                                                           15    9605
XP_005273329                                                           15    9605
>NP_001244163
          Length = 954

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>NP_001244166
          Length = 954

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>NP_001244159
          Length = 954

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>NP_001244160
          Length = 1059

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 624 SHRQMS 629
>NP_001093392
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>NP_057323
          Length = 3530

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LVSSHRQMS 9
            LVS HRQ +
Sbjct: 3384 LVSQHRQQT 3392
>XP_006724767
          Length = 641

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 206 SHRQMS 211
>XP_006724766
          Length = 645

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 210 SHRQMS 215
>XP_006724765
          Length = 652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 217 SHRQMS 222
>XP_006724764
          Length = 861

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>XP_006724763
          Length = 901

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>XP_006724762
          Length = 903

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>XP_006724761
          Length = 1033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>XP_006724760
          Length = 1033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>XP_006724759
          Length = 1033

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 598 SHRQMS 603
>XP_006724758
          Length = 1058

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>XP_006724757
          Length = 1080

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 645 SHRQMS 650
>XP_006724756
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SHRQMS 9
           SHRQMS
Sbjct: 702 SHRQMS 707
>XP_005256732
          Length = 3531

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LVSSHRQMS 9
            LVS HRQ +
Sbjct: 3385 LVSQHRQQT 3393
>XP_006718366
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VSSHRQMS 9
          VSSHR +S
Sbjct: 40 VSSHRTLS 47
>XP_005253166
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VSSHRQMS 9
          VSSHR +S
Sbjct: 40 VSSHRTLS 47
>NP_004445
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           S HRQMS
Sbjct: 242 SYHRQMS 248
>NP_733751
          Length = 4911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4126 LVSSHR 4131
>NP_001161437
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>NP_113621
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVSSHRQMS 9
           LVSSH +++
Sbjct: 385 LVSSHHELA 393
>NP_689711
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>NP_001182760
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>NP_775934
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>NP_079466
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>NP_001252544
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>XP_006716142
          Length = 4927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4142 LVSSHR 4147
>XP_005250088
          Length = 4928

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4143 LVSSHR 4148
>XP_006716141
          Length = 4959

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4174 LVSSHR 4179
>XP_005250085
          Length = 4979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4198 LVSSHR 4203
>XP_006716140
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4197 LVSSHR 4202
>XP_005250084
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4197 LVSSHR 4202
>XP_005250083
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4197 LVSSHR 4202
>XP_005250082
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVSSHR 6
            LVSSHR
Sbjct: 4198 LVSSHR 4203
>XP_006714917
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>XP_006714916
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>XP_006714915
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 148 ITGSHQQMS 156
>XP_006714914
          Length = 334

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 275 ITGSHQQMS 283
>XP_006714913
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 240 ITGSHQQMS 248
>XP_006714912
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>XP_006714911
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 251 ITGSHQQMS 259
>XP_006714910
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 252 ITGSHQQMS 260
>XP_006714909
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 252 ITGSHQQMS 260
>XP_006714908
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 252 ITGSHQQMS 260
>XP_006714907
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 252 ITGSHQQMS 260
>XP_006714906
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 252 ITGSHQQMS 260
>XP_006714905
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 280 ITGSHQQMS 288
>XP_006714904
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 294 ITGSHQQMS 302
>XP_005265946
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVSSHRQMS 9
           +  SH+QMS
Sbjct: 328 ITGSHQQMS 336
>XP_006712733
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_006712732
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_006712731
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 276 VSSHKQPS 283
>XP_006712730
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 280 VSSHKQPS 287
>XP_006712729
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 295 VSSHKQPS 302
>XP_006712728
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 481 VSSHKQPS 488
>XP_006712727
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 493 VSSHKQPS 500
>XP_006712726
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_006712725
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_006712724
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_005264052
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VSSHRQMS 9
           VSSH+Q S
Sbjct: 527 VSSHKQPS 534
>XP_006710447
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>XP_006710446
          Length = 1239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 264 SSHSQMS 270
>XP_006710445
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>XP_005270577
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SSHRQMS 9
           SSH QMS
Sbjct: 275 SSHSQMS 281
>NP_003382
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVSSHRQM 8
          LVSS RQ+
Sbjct: 47 LVSSQRQL 54
>NP_055616
          Length = 2137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    LVSSHRQM 8
            L+S+HR++
Sbjct: 1210 LISNHRRL 1217
>XP_006716172
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVSSHRQM 8
          LVSS RQ+
Sbjct: 18 LVSSQRQL 25
>XP_006711879
          Length = 1364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    LVSSHRQM 8
            L+S+HR++
Sbjct: 1210 LISNHRRL 1217
>XP_005273329
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    LVSSHRQM 8
            L+S+HR++
Sbjct: 1007 LISNHRRL 1014
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.113    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 571,712
Number of extensions: 660
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package