Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     390
NP_066124                                                              20     390
XP_006717999                                                           20     390
NP_001258558                                                           17    4312
NP_005911                                                              17    4312
NP_071903                                                              17    4312
XP_005249613                                                           17    4312
XP_006711396                                                           17    4312
XP_005245226                                                           17    4312
XP_005245227                                                           17    4312
XP_006711394                                                           17    4312
XP_006711393                                                           17    4312
NP_775823                                                              16    5631
NP_001265209                                                           16    7355
NP_060916                                                              16    7355
NP_001265210                                                           16    7355
NP_690909                                                              16    7355
NP_001010983                                                           16    7355
NP_079390                                                              16    7355
NP_003346                                                              16    7355
XP_006719673                                                           16    7355
XP_005269218                                                           16    7355
XP_005269217                                                           16    7355
XP_006719672                                                           16    7355
XP_005269215                                                           16    7355
XP_006713323                                                           16    7355
NP_001278017                                                           15    9605
NP_114157                                                              15    9605
NP_997191                                                              15    9605
NP_065976                                                              15    9605
NP_115927                                                              15    9605
NP_001152956                                                           15    9605
NP_056083                                                              15    9605
XP_006723474                                                           15    9605
XP_005259362                                                           15    9605
XP_006715292                                                           15    9605
XP_005247302                                                           15    9605
XP_006711682                                                           15    9605
XP_006710856                                                           15    9605
>NP_065681
          Length = 1072

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVRRYTSTV 9
           LVRRYTST+
Sbjct: 310 LVRRYTSTL 318
>NP_066124
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVRRYTSTV 9
           LVRRYTST+
Sbjct: 310 LVRRYTSTL 318
>XP_006717999
          Length = 1207

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVRRYTSTV 9
           LVRRYTST+
Sbjct: 403 LVRRYTSTL 411
>NP_001258558
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>NP_005911
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>NP_071903
          Length = 490

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           LVR++TS V
Sbjct: 446 LVRKFTSAV 454
>XP_005249613
          Length = 338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           LVR++TS V
Sbjct: 294 LVRKFTSAV 302
>XP_006711396
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>XP_005245226
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>XP_005245227
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>XP_006711394
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>XP_006711393
          Length = 521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVRRYTSTV 9
           L RRY STV
Sbjct: 127 LFRRYGSTV 135
>NP_775823
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVRRYTST 8
           LVRRY  T
Sbjct: 179 LVRRYAET 186
>NP_001265209
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_060916
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_001265210
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_690909
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_001010983
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_079390
          Length = 2479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 896 LIRQYTTLV 904
>NP_003346
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RRYTSTV 9
           RRY STV
Sbjct: 154 RRYQSTV 160
>XP_006719673
          Length = 1997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 414 LIRQYTTLV 422
>XP_005269218
          Length = 2009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 426 LIRQYTTLV 434
>XP_005269217
          Length = 2353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 927 LIRQYTTLV 935
>XP_006719672
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 927 LIRQYTTLV 935
>XP_005269215
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVRRYTSTV 9
           L+R+YT+ V
Sbjct: 927 LIRQYTTLV 935
>XP_006713323
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LVRRYT 6
           L+RRYT
Sbjct: 360 LIRRYT 365
>NP_001278017
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           V+R+TST
Sbjct: 232 VKRFTST 238
>NP_114157
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           V+R+TST
Sbjct: 193 VKRFTST 199
>NP_997191
          Length = 1888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    RRYTST 8
            R+YTST
Sbjct: 1070 RKYTST 1075
>NP_065976
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVRRYTST 8
           +VRRY +T
Sbjct: 677 IVRRYIAT 684
>NP_115927
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVRRYTST 8
           L R+YT+T
Sbjct: 179 LARQYTNT 186
>NP_001152956
          Length = 1736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    RRYTST 8
            R+YTST
Sbjct: 1070 RKYTST 1075
>NP_056083
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           VR+Y+ST
Sbjct: 303 VRKYSST 309
>XP_006723474
          Length = 2737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           V+R+TST
Sbjct: 232 VKRFTST 238
>XP_005259362
          Length = 2855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           V+R+TST
Sbjct: 175 VKRFTST 181
>XP_006715292
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVRRYTST 8
           L R+YT+T
Sbjct: 166 LARQYTNT 173
>XP_005247302
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRRYTST 8
           VR+Y+ST
Sbjct: 303 VRKYSST 309
>XP_006711682
          Length = 1739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRYTST 8
           R+YTST
Sbjct: 921 RKYTST 926
>XP_006710856
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVRRYTST 8
           +VRRY +T
Sbjct: 432 IVRRYIAT 439
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.133    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,836
Number of extensions: 514
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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