Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919289                                                              17    3301
NP_005723                                                              17    4312
NP_000467                                                              17    4312
XP_005251845                                                           17    4312
XP_005251843                                                           17    4312
NP_001073121                                                           16    5631
NP_689957                                                              16    5631
NP_112483                                                              16    5631
NP_056382                                                              16    5631
NP_690048                                                              16    5631
NP_001230462                                                           16    5631
NP_001230461                                                           16    5631
XP_005262364                                                           16    5631
XP_005262363                                                           16    5631
XP_005262362                                                           16    5631
XP_005262361                                                           16    5631
XP_005262360                                                           16    5631
XP_005262358                                                           16    5631
XP_005254096                                                           16    5631
XP_005254095                                                           16    5631
XP_005245800                                                           16    5631
NP_001166148                                                           16    7355
NP_116078                                                              16    7355
NP_001229642                                                           16    7355
NP_036244                                                              16    7355
XP_005260397                                                           16    7355
XP_006723504                                                           16    7355
XP_006723502                                                           16    7355
XP_006723501                                                           16    7355
XP_006723499                                                           16    7355
XP_006723498                                                           16    7355
XP_006717822                                                           16    7355
XP_006717821                                                           16    7355
XP_005269749                                                           16    7355
XP_006717820                                                           16    7355
NP_065081                                                              16    7355
NP_000400                                                              15    9605
NP_443137                                                              15    9605
NP_036430                                                              15    9605
NP_065768                                                              15    9605
NP_115827                                                              15    9605
NP_940931                                                              15    9605
XP_006724654                                                           15    9605
XP_006724653                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_006721370                                                           15    9605
XP_006721369                                                           15    9605
XP_006721368                                                           15    9605
XP_006721367                                                           15    9605
XP_006721366                                                           15    9605
XP_006721365                                                           15    9605
XP_006720120                                                           15    9605
XP_006720119                                                           15    9605
XP_005266116                                                           15    9605
XP_006715136                                                           15    9605
XP_005246323                                                           15    9605
XP_005246322                                                           15    9605
XP_006712291                                                           15    9605
XP_005246320                                                           15    9605
NP_689659                                                              15    9605
NP_001155971                                                           15    9605
NP_060918                                                              15    9605
>NP_919289
          Length = 1368

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           +REV+RGE
Sbjct: 235 MREVRRGE 242
>NP_005723
          Length = 1312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           LVRE Q GE
Sbjct: 399 LVRERQEGE 407
>NP_000467
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   REVQRGE 9
           REVQ+GE
Sbjct: 97  REVQQGE 103
>XP_005251845
          Length = 187

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  REVQRGE 9
          REVQ+GE
Sbjct: 90 REVQQGE 96
>XP_005251843
          Length = 210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   REVQRGE 9
           REVQ+GE
Sbjct: 113 REVQQGE 119
>NP_001073121
          Length = 679

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VREVQRGE 9
          VRE+ RGE
Sbjct: 3  VRELPRGE 10
>NP_689957
          Length = 2213

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    VREVQRGE 9
            VRE+ RGE
Sbjct: 1516 VRELPRGE 1523
>NP_112483
          Length = 734

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>NP_056382
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVREVQRG 8
           L+RE+Q G
Sbjct: 492 LIREIQSG 499
>NP_690048
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVREVQRG 8
          L+REV RG
Sbjct: 10 LIREVGRG 17
>NP_001230462
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVREVQRG 8
          L+REV RG
Sbjct: 10 LIREVGRG 17
>NP_001230461
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVREVQRG 8
          L+REV RG
Sbjct: 10 LIREVGRG 17
>XP_005262364
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  EVQRGE 9
          EVQRGE
Sbjct: 50 EVQRGE 55
>XP_005262363
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>XP_005262362
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>XP_005262361
          Length = 536

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>XP_005262360
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>XP_005262358
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EVQRGE 9
           EVQRGE
Sbjct: 352 EVQRGE 357
>XP_005254096
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVREVQRG 8
           L+RE+Q G
Sbjct: 492 LIREIQSG 499
>XP_005254095
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVREVQRG 8
           L+RE+Q G
Sbjct: 492 LIREIQSG 499
>XP_005245800
          Length = 341

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LVREVQRG 8
          L+REV RG
Sbjct: 10 LIREVGRG 17
>NP_001166148
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 67 IVREETRGE 75
>NP_116078
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 68 IVREETRGE 76
>NP_001229642
          Length = 102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VREVQRGE 9
          V+EV++GE
Sbjct: 62 VKEVEQGE 69
>NP_036244
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           ++E+Q+GE
Sbjct: 555 IKELQKGE 562
>XP_005260397
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           ++E+Q+GE
Sbjct: 555 IKELQKGE 562
>XP_006723504
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 2  IVREETRGE 10
>XP_006723502
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 34 IVREETRGE 42
>XP_006723501
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 34 IVREETRGE 42
>XP_006723499
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 67 IVREETRGE 75
>XP_006723498
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVREVQRGE 9
          +VRE  RGE
Sbjct: 68 IVREETRGE 76
>XP_006717822
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           VRE+++GE
Sbjct: 164 VRELRKGE 171
>XP_006717821
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           VRE+++GE
Sbjct: 164 VRELRKGE 171
>XP_005269749
          Length = 901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           VRE+++GE
Sbjct: 164 VRELRKGE 171
>XP_006717820
          Length = 949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           VRE+++GE
Sbjct: 164 VRELRKGE 171
>NP_065081
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VREVQRGE 9
           VRE+++GE
Sbjct: 164 VRELRKGE 171
>NP_000400
          Length = 201

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           +VR +Q GE
Sbjct: 179 IVRRLQNGE 187
>NP_443137
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VREVQRG 8
           V+E+QRG
Sbjct: 903 VKELQRG 909
>NP_036430
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVREVQRG 8
           L+REV+ G
Sbjct: 950 LIREVEMG 957
>NP_065768
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LVREVQRG 8
            ++RE QRG
Sbjct: 1327 VLREAQRG 1334
>NP_115827
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 249 LMRELRRG 256
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    VREVQR 7
            VREVQR
Sbjct: 1317 VREVQR 1322
>XP_006724654
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LVREVQRG 8
            ++RE QRG
Sbjct: 1169 VLREAQRG 1176
>XP_006724653
          Length = 1377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LVREVQRG 8
            ++RE QRG
Sbjct: 1211 VLREAQRG 1218
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    VREVQR 7
            VREVQR
Sbjct: 1317 VREVQR 1322
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    VREVQR 7
            VREVQR
Sbjct: 1317 VREVQR 1322
>XP_006721370
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 249 LMRELRRG 256
>XP_006721369
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 249 LMRELRRG 256
>XP_006721368
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 249 LMRELRRG 256
>XP_006721367
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 249 LMRELRRG 256
>XP_006721366
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 164 LMRELRRG 171
>XP_006721365
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVREVQRG 8
           L+RE++RG
Sbjct: 164 LMRELRRG 171
>XP_006720120
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           L RE++ GE
Sbjct: 366 LTRELENGE 374
>XP_006720119
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           L RE++ GE
Sbjct: 405 LTRELENGE 413
>XP_005266116
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVREVQRG 8
           L+RE +RG
Sbjct: 468 LIREYRRG 475
>XP_006715136
          Length = 128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           +VR +Q GE
Sbjct: 106 IVRRLQNGE 114
>XP_005246323
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VREVQRG 8
           V+E+QRG
Sbjct: 880 VKELQRG 886
>XP_005246322
          Length = 1084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VREVQRG 8
           V+E+QRG
Sbjct: 903 VKELQRG 909
>XP_006712291
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VREVQRG 8
           V+E+QRG
Sbjct: 903 VKELQRG 909
>XP_005246320
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VREVQRG 8
           V+E+QRG
Sbjct: 903 VKELQRG 909
>NP_689659
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVREVQRGE 9
           L RE++ GE
Sbjct: 405 LTRELENGE 413
>NP_001155971
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LVREVQRG 8
            L+REV+ G
Sbjct: 1067 LIREVEMG 1074
>NP_060918
          Length = 1230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LVREVQRG 8
            L+REV+ G
Sbjct: 1062 LIREVEMG 1069
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.140    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 535,303
Number of extensions: 921
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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