Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_005348                                                              18    1935
XP_005258994                                                           18    1935
NP_055951                                                              17    2528
XP_005265031                                                           17    2528
XP_005265030                                                           17    2528
NP_996832                                                              17    3301
XP_006725224                                                           17    3301
XP_005267371                                                           17    3301
NP_660292                                                              17    3301
XP_005264802                                                           17    4312
NP_776185                                                              17    4312
NP_000426                                                              16    5631
NP_149118                                                              16    5631
XP_005259981                                                           16    5631
NP_000227                                                              15    9605
NP_001161210                                                           15    9605
NP_116165                                                              15    9605
NP_065176                                                              15    9605
NP_001269877                                                           15    9605
NP_061113                                                              15    9605
NP_001229518                                                           15    9605
NP_054760                                                              15    9605
NP_062541                                                              15    9605
NP_671494                                                              15    9605
NP_001138548                                                           15    9605
NP_006268                                                              15    9605
NP_061936                                                              15    9605
NP_006480                                                              15    9605
NP_002506                                                              15    9605
XP_006725154                                                           15    9605
XP_006720565                                                           15    9605
XP_005254431                                                           15    9605
XP_006720564                                                           15    9605
XP_005254429                                                           15    9605
XP_005267764                                                           15    9605
XP_005269685                                                           15    9605
XP_005269684                                                           15    9605
XP_005269683                                                           15    9605
XP_005269681                                                           15    9605
XP_006717770                                                           15    9605
XP_005269679                                                           15    9605
XP_006716678                                                           15    9605
XP_005264325                                                           15    9605
XP_006712054                                                           15    9605
XP_005264324                                                           15    9605
XP_006711674                                                           15    9605
XP_006711673                                                           15    9605
XP_006711672                                                           15    9605
XP_006711671                                                           15    9605
XP_006711670                                                           15    9605
XP_005245629                                                           15    9605
NP_001094348                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV SGFAGT
Sbjct: 1825 LVRSGFAGT 1833
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV SGFAGT
Sbjct: 1825 LVRSGFAGT 1833
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV SGFAGT
Sbjct: 1778 LVRSGFAGT 1786
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV SGFAGT
Sbjct: 1857 LVRSGFAGT 1865
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV SGFAGT
Sbjct: 1857 LVRSGFAGT 1865
>NP_005348
          Length = 1076

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VMSGFAGT 9
           VMSG++GT
Sbjct: 270 VMSGYSGT 277
>XP_005258994
          Length = 1000

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VMSGFAGT 9
           VMSG++GT
Sbjct: 270 VMSGYSGT 277
>NP_055951
          Length = 2570

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMSGFAGT 9
            L  SGFAGT
Sbjct: 1996 LCRSGFAGT 2004
>XP_005265031
          Length = 2569

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMSGFAGT 9
            L  SGFAGT
Sbjct: 1996 LCRSGFAGT 2004
>XP_005265030
          Length = 2595

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LVMSGFAGT 9
            L  SGFAGT
Sbjct: 1996 LCRSGFAGT 2004
>NP_996832
          Length = 104

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMSGFAGT 9
          V+ GFAGT
Sbjct: 85 VIGGFAGT 92
>XP_006725224
          Length = 129

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VMSGFAGT 9
           V+ GFAGT
Sbjct: 110 VIGGFAGT 117
>XP_005267371
          Length = 129

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VMSGFAGT 9
           V+ GFAGT
Sbjct: 110 VIGGFAGT 117
>NP_660292
          Length = 104

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VMSGFAGT 9
          V+ GFAGT
Sbjct: 85 VIGGFAGT 92
>XP_005264802
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           LVM G AGT
Sbjct: 230 LVMVGVAGT 238
>NP_776185
          Length = 329

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           LVM G AGT
Sbjct: 231 LVMVGVAGT 239
>NP_000426
          Length = 2321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           + M+GF GT
Sbjct: 456 ICMAGFTGT 464
>NP_149118
          Length = 1060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VMSGFAGT 9
           VMSGF  T
Sbjct: 485 VMSGFTST 492
>XP_005259981
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           + M+GF GT
Sbjct: 456 ICMAGFTGT 464
>NP_000227
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSGFAGT 9
           +SGFAG+
Sbjct: 173 VSGFAGS 179
>NP_001161210
          Length = 1483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1160 LVLSGPSGT 1168
>NP_116165
          Length = 2540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1471 SGFSGT 1476
>NP_065176
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1554 LVLSGPSGT 1562
>NP_001269877
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1289 SGFSGT 1294
>NP_061113
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           +V  GF+GT
Sbjct: 132 VVTKGFSGT 140
>NP_001229518
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMSGFAGT 9
           +V  GF+GT
Sbjct: 132 VVTKGFSGT 140
>NP_054760
          Length = 169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LVMSGFA 7
           +VM+GFA
Sbjct: 118 IVMAGFA 124
>NP_062541
          Length = 1670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LVMSGFAG 8
           L+M GF G
Sbjct: 195 LMMGGFGG 202
>NP_671494
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LVMSGFAG 8
           L+M GF G
Sbjct: 195 LMMGGFGG 202
>NP_001138548
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MSGFAGT 9
         M GFAG+
Sbjct: 1 MDGFAGS 7
>NP_006268
          Length = 1697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LVMSGFAG 8
           L+M GF G
Sbjct: 195 LMMGGFGG 202
>NP_061936
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MSGFAGT 9
         M GFAG+
Sbjct: 1 MDGFAGS 7
>NP_006480
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VMSGFAG 8
           V+SGF G
Sbjct: 279 VLSGFTG 285
>NP_002506
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VMSGFAG 8
           V+SGF G
Sbjct: 303 VLSGFTG 309
>XP_006725154
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SGFAGT 9
           +GFAGT
Sbjct: 123 AGFAGT 128
>XP_006720565
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSGFAGT 9
           +SGFAG+
Sbjct: 126 VSGFAGS 132
>XP_005254431
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSGFAGT 9
           +SGFAG+
Sbjct: 152 VSGFAGS 158
>XP_006720564
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSGFAGT 9
           +SGFAG+
Sbjct: 173 VSGFAGS 179
>XP_005254429
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSGFAGT 9
           +SGFAG+
Sbjct: 173 VSGFAGS 179
>XP_005267764
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VMSGFAG 8
           V+SGF G
Sbjct: 181 VLSGFTG 187
>XP_005269685
          Length = 1700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1471 SGFSGT 1476
>XP_005269684
          Length = 2032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1471 SGFSGT 1476
>XP_005269683
          Length = 2252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1183 SGFSGT 1188
>XP_005269681
          Length = 2321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1252 SGFSGT 1257
>XP_006717770
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1289 SGFSGT 1294
>XP_005269679
          Length = 2502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SGFAGT 9
            SGF+GT
Sbjct: 1433 SGFSGT 1438
>XP_006716678
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SGFAGT 9
           +GFAGT
Sbjct: 123 AGFAGT 128
>XP_005264325
          Length = 762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MSGFAGT 9
         M GFAG+
Sbjct: 1 MDGFAGS 7
>XP_006712054
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MSGFAGT 9
         M GFAG+
Sbjct: 1 MDGFAGS 7
>XP_005264324
          Length = 992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3 MSGFAGT 9
         M GFAG+
Sbjct: 1 MDGFAGS 7
>XP_006711674
          Length = 1385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1062 LVLSGPSGT 1070
>XP_006711673
          Length = 1549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1226 LVLSGPSGT 1234
>XP_006711672
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1234 LVLSGPSGT 1242
>XP_006711671
          Length = 2153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1830 LVLSGPSGT 1838
>XP_006711670
          Length = 2161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1838 LVLSGPSGT 1846
>XP_005245629
          Length = 2164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVMSGFAGT 9
            LV+SG +GT
Sbjct: 1841 LVLSGPSGT 1849
>NP_001094348
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   SGFAGT 9
           +GFAGT
Sbjct: 123 AGFAGT 128
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.139    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 442,726
Number of extensions: 615
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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