Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001239049                                                           16    5631
NP_055963                                                              16    5631
NP_001239053                                                           16    5631
NP_001239051                                                           16    5631
NP_001239048                                                           16    5631
XP_006725868                                                           16    5631
XP_006725749                                                           16    5631
XP_005247048                                                           16    5631
XP_005247047                                                           16    5631
NP_001231743                                                           16    7355
NP_001231741                                                           16    7355
NP_001231739                                                           16    7355
NP_001231745                                                           16    7355
NP_116071                                                              16    7355
NP_001231744                                                           16    7355
NP_001231742                                                           16    7355
NP_001231737                                                           16    7355
XP_005264786                                                           16    7355
XP_006713169                                                           16    7355
XP_005264799                                                           16    7355
XP_006713168                                                           16    7355
XP_005264795                                                           16    7355
XP_005264794                                                           16    7355
XP_006713167                                                           16    7355
XP_006713166                                                           16    7355
XP_006713165                                                           16    7355
XP_005264793                                                           16    7355
XP_005264792                                                           16    7355
NP_079331                                                              15    9605
NP_612201                                                              15    9605
XP_006721797                                                           15    9605
XP_006721796                                                           15    9605
XP_006720761                                                           15    9605
XP_005254749                                                           15    9605
XP_006720760                                                           15    9605
NP_705834                                                              15    9605
NP_001157394                                                           15    9605
>NP_001239049
          Length = 1323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LVMESHSS 8
            LVME H S
Sbjct: 1079 LVMEKHGS 1086
>NP_055963
          Length = 1323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LVMESHSS 8
            LVME H S
Sbjct: 1079 LVMEKHGS 1086
>NP_001239053
          Length = 1143

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LVMESHSS 8
            LVME H S
Sbjct: 1079 LVMEKHGS 1086
>NP_001239051
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LVMESHSS 8
            LVME H S
Sbjct: 1044 LVMEKHGS 1051
>NP_001239048
          Length = 1330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LVMESHSS 8
            LVME H S
Sbjct: 1079 LVMEKHGS 1086
>XP_006725868
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VMESHSS 8
          +M+SHSS
Sbjct: 23 IMQSHSS 29
>XP_006725749
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VMESHSS 8
          +M+SHSS
Sbjct: 23 IMQSHSS 29
>XP_005247048
          Length = 1107

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVMESHSS 8
           LVME H S
Sbjct: 863 LVMEKHGS 870
>XP_005247047
          Length = 1137

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LVMESHSS 8
           LVME H S
Sbjct: 893 LVMEKHGS 900
>NP_001231743
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>NP_001231741
          Length = 601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 193 LIMNPHAST 201
>NP_001231739
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>NP_001231745
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>NP_116071
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>NP_001231744
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 271 LIMNPHAST 279
>NP_001231742
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 169 LIMNPHAST 177
>NP_001231737
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_005264786
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_006713169
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 271 LIMNPHAST 279
>XP_005264799
          Length = 576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 168 LIMNPHAST 176
>XP_006713168
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 176 LIMNPHAST 184
>XP_005264795
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_005264794
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 268 LIMNPHAST 276
>XP_006713167
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_006713166
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_006713165
          Length = 677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 269 LIMNPHAST 277
>XP_005264793
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 271 LIMNPHAST 279
>XP_005264792
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVMESHSST 9
           L+M  H+ST
Sbjct: 270 LIMNPHAST 278
>NP_079331
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVMESHSST 9
           LV+E +SST
Sbjct: 287 LVLEYYSST 295
>NP_612201
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VMESHSS 8
          ++ESHSS
Sbjct: 62 LLESHSS 68
>XP_006721797
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VMESHSS 8
          ++ESHSS
Sbjct: 20 LLESHSS 26
>XP_006721796
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  VMESHSS 8
          ++ESHSS
Sbjct: 54 LLESHSS 60
>XP_006720761
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVMESHSST 9
           LV+E +SST
Sbjct: 287 LVLEYYSST 295
>XP_005254749
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVMESHSST 9
           LV+E +SST
Sbjct: 287 LVLEYYSST 295
>XP_006720760
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVMESHSST 9
           LV+E +SST
Sbjct: 511 LVLEYYSST 519
>NP_705834
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MESHSST 9
           MES+SST
Sbjct: 178 MESNSST 184
>NP_001157394
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MESHSST 9
           +E HSST
Sbjct: 848 LEDHSST 854
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.104    0.249 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,631
Number of extensions: 569
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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