Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              17    4312
NP_036434                                                              17    4312
XP_006717989                                                           17    4312
XP_005270731                                                           17    4312
XP_005270730                                                           17    4312
XP_006710560                                                           17    4312
XP_006710559                                                           17    4312
XP_006710558                                                           17    4312
XP_006710557                                                           17    4312
XP_006710556                                                           17    4312
XP_006710555                                                           17    4312
XP_005270727                                                           17    4312
XP_006710554                                                           17    4312
XP_005270725                                                           17    4312
XP_005270724                                                           17    4312
XP_006710553                                                           17    4312
XP_005270723                                                           17    4312
XP_006710552                                                           17    4312
XP_006710551                                                           17    4312
XP_006710550                                                           17    4312
XP_006710549                                                           17    4312
XP_006710548                                                           17    4312
NP_001033794                                                           16    7355
NP_002784                                                              15    9605
XP_005273127                                                           15    9605
>NP_000305
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LVLTLTK 7
           LVLTLTK
Sbjct: 316 LVLTLTK 322
>NP_036434
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_006717989
          Length = 388

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LVLTLTK 7
           LVLTLTK
Sbjct: 301 LVLTLTK 307
>XP_005270731
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_005270730
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_006710560
          Length = 1181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710559
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710558
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710557
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710556
          Length = 1195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710555
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_005270727
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_006710554
          Length = 1421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_005270725
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_005270724
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 996  LVITLCKMV 1004
>XP_006710553
          Length = 1451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1001 LVITLCKMV 1009
>XP_005270723
          Length = 1459

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1009 LVITLCKMV 1017
>XP_006710552
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710551
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710550
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710549
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>XP_006710548
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LVLTLTKMI 9
            LV+TL KM+
Sbjct: 1014 LVITLCKMV 1022
>NP_001033794
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVLTLTKMI 9
           L+L LTK++
Sbjct: 313 LILALTKVV 321
>NP_002784
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LTLTKMI 9
          LTLTK+I
Sbjct: 90 LTLTKII 96
>XP_005273127
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  VLTLTKM 8
          VLTLTK+
Sbjct: 18 VLTLTKV 24
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.147    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 272,448
Number of extensions: 245
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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