Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              18    1135
XP_006718907                                                           18    1135
XP_006718906                                                           18    1135
XP_005271619                                                           18    1135
XP_005271618                                                           18    1135
NP_001274359                                                           17    3301
NP_001007243                                                           17    3301
NP_001274355                                                           17    3301
NP_001274358                                                           17    3301
NP_003355                                                              17    3301
NP_001274357                                                           17    3301
XP_005255318                                                           17    3301
XP_005255316                                                           17    3301
XP_005249895                                                           17    3301
NP_001007241                                                           17    3301
NP_001007242                                                           17    3301
NP_001493                                                              17    3301
NP_003943                                                              16    7355
NP_056151                                                              16    7355
NP_001107604                                                           16    7355
NP_115830                                                              16    7355
NP_004188                                                              16    7355
NP_055646                                                              16    7355
XP_005268808                                                           16    7355
XP_006718720                                                           16    7355
XP_006718719                                                           16    7355
XP_005274222                                                           16    7355
XP_006718718                                                           16    7355
XP_005274221                                                           16    7355
XP_006713495                                                           16    7355
XP_006712765                                                           16    7355
XP_006712764                                                           16    7355
XP_005246844                                                           16    7355
XP_006712763                                                           16    7355
XP_006712762                                                           16    7355
XP_006712761                                                           16    7355
NP_852091                                                              15    9605
NP_003038                                                              15    9605
NP_055616                                                              15    9605
NP_059129                                                              15    9605
NP_872409                                                              15    9605
XP_006718595                                                           15    9605
XP_006717897                                                           15    9605
XP_006717896                                                           15    9605
XP_005273329                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVKYFIKRA 9
           LVKYFIK A
Sbjct: 100 LVKYFIKCA 108
>XP_006718907
          Length = 3050

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVKYFIKRA 9
           LVKYFIK A
Sbjct: 100 LVKYFIKCA 108
>XP_006718906
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVKYFIKRA 9
           LVKYFIK A
Sbjct: 100 LVKYFIKCA 108
>XP_005271619
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVKYFIKRA 9
           LVKYFIK A
Sbjct: 100 LVKYFIKCA 108
>XP_005271618
          Length = 3056

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVKYFIKRA 9
           LVKYFIK A
Sbjct: 100 LVKYFIKCA 108
>NP_001274359
          Length = 173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 161 LVSYFIKK 168
>NP_001007243
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 262 LVKYFIIR 269
>NP_001274355
          Length = 310

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 298 LVSYFIKK 305
>NP_001274358
          Length = 173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 161 LVSYFIKK 168
>NP_003355
          Length = 310

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 298 LVSYFIKK 305
>NP_001274357
          Length = 173

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 161 LVSYFIKK 168
>XP_005255318
          Length = 512

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 387 LVKYFIIR 394
>XP_005255316
          Length = 659

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 534 LVKYFIIR 541
>XP_005249895
          Length = 246

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LV YFIK+
Sbjct: 234 LVSYFIKK 241
>NP_001007241
          Length = 537

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 412 LVKYFIIR 419
>NP_001007242
          Length = 390

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 265 LVKYFIIR 272
>NP_001493
          Length = 534

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKYFI R
Sbjct: 409 LVKYFIIR 416
>NP_003943
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 299 LVKKFLKR 306
>NP_056151
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKY+I +
Sbjct: 105 LVKYYISK 112
>NP_001107604
          Length = 2694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 936 IVKHFIQR 943
>NP_115830
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           +KYF+K
Sbjct: 299 IKYFVK 304
>NP_004188
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           +KYF+K
Sbjct: 295 IKYFVK 300
>NP_055646
          Length = 2925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    KYFIKR 8
            KYFI+R
Sbjct: 1669 KYFIRR 1674
>XP_005268808
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVKY+I +
Sbjct: 105 LVKYYISK 112
>XP_006718720
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 99  LVKKFLKR 106
>XP_006718719
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 99  LVKKFLKR 106
>XP_005274222
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 99  LVKKFLKR 106
>XP_006718718
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 99  LVKKFLKR 106
>XP_005274221
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 202 LVKKFLKR 209
>XP_006713495
          Length = 2969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    KYFIKR 8
            KYFI+R
Sbjct: 1713 KYFIRR 1718
>XP_006712765
          Length = 2679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 908 IVKHFIQR 915
>XP_006712764
          Length = 2697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 965 IVKHFIQR 972
>XP_005246844
          Length = 2707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 936 IVKHFIQR 943
>XP_006712763
          Length = 2716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 965 IVKHFIQR 972
>XP_006712762
          Length = 2723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 965 IVKHFIQR 972
>XP_006712761
          Length = 2736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVKYFIKR 8
           +VK+FI+R
Sbjct: 965 IVKHFIQR 972
>NP_852091
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YFIKRA 9
           YFIK+A
Sbjct: 513 YFIKKA 518
>NP_003038
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           +KYF+K
Sbjct: 379 IKYFLK 384
>NP_055616
          Length = 2137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LVKYFIK 7
            L++Y+IK
Sbjct: 1529 LIRYYIK 1535
>NP_059129
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LVKYFIKR 8
           LVK F+KR
Sbjct: 111 LVKGFLKR 118
>NP_872409
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           VKYFI+
Sbjct: 341 VKYFIR 346
>XP_006718595
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           VKYFI+
Sbjct: 341 VKYFIR 346
>XP_006717897
          Length = 1160

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           +KYFIK
Sbjct: 224 LKYFIK 229
>XP_006717896
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   VKYFIK 7
           +KYFIK
Sbjct: 250 LKYFIK 255
>XP_005273329
          Length = 1934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    LVKYFIK 7
            L++Y+IK
Sbjct: 1326 LIRYYIK 1332
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.154    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 403,690
Number of extensions: 529
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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