Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           19     665
NP_004561                                                              19     665
NP_001275703                                                           19     665
XP_005253450                                                           19     665
XP_006719151                                                           19     665
NP_001005329                                                           17    2528
NP_001004748                                                           17    2528
NP_002444                                                              17    3301
NP_001005369                                                           17    3301
XP_006712087                                                           17    3301
XP_005264392                                                           17    3301
XP_006712086                                                           17    3301
NP_996879                                                              17    4312
XP_006720120                                                           17    4312
XP_006720119                                                           17    4312
XP_006710494                                                           17    4312
XP_006710492                                                           17    4312
XP_006710491                                                           17    4312
XP_006710490                                                           17    4312
XP_006710489                                                           17    4312
NP_689659                                                              17    4312
NP_775184                                                              16    5631
NP_001241681                                                           16    5631
NP_115945                                                              16    5631
NP_689562                                                              16    5631
NP_060862                                                              16    5631
XP_006716715                                                           16    5631
XP_005263172                                                           16    5631
NP_001004749                                                           16    5631
NP_001136123                                                           16    7355
NP_115549                                                              16    7355
NP_689955                                                              16    7355
NP_075463                                                              16    7355
NP_001193927                                                           16    7355
NP_071338                                                              16    7355
XP_005261831                                                           16    7355
XP_006724396                                                           16    7355
XP_005261830                                                           16    7355
XP_006719812                                                           16    7355
XP_006717983                                                           16    7355
XP_005270036                                                           16    7355
XP_005270035                                                           16    7355
NP_942090                                                              16    7355
NP_001004485                                                           16    7355
NP_115785                                                              15    9605
NP_005126                                                              15    9605
NP_598408                                                              15    9605
NP_001035959                                                           15    9605
NP_001035962                                                           15    9605
NP_001035960                                                           15    9605
NP_001035961                                                           15    9605
NP_079472                                                              15    9605
NP_001035304                                                           15    9605
NP_699186                                                              15    9605
NP_006648                                                              15    9605
NP_996848                                                              15    9605
XP_006726449                                                           15    9605
XP_005274666                                                           15    9605
XP_005274659                                                           15    9605
XP_006724024                                                           15    9605
XP_006720856                                                           15    9605
XP_005266891                                                           15    9605
XP_006712222                                                           15    9605
NP_612157                                                              15    9605
>NP_001275701
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVCVETKQI 9
           L CVETKQI
Sbjct: 441 LGCVETKQI 449
>NP_004561
          Length = 1445

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVCVETKQI 9
           L CVETKQI
Sbjct: 441 LGCVETKQI 449
>NP_001275703
          Length = 1264

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVCVETKQI 9
           L CVETKQI
Sbjct: 219 LGCVETKQI 227
>XP_005253450
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVCVETKQI 9
           L CVETKQI
Sbjct: 441 LGCVETKQI 449
>XP_006719151
          Length = 1486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVCVETKQI 9
           L CVETKQI
Sbjct: 441 LGCVETKQI 449
>NP_001005329
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   CVETKQI 9
           CV+TKQI
Sbjct: 294 CVKTKQI 300
>NP_001004748
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   CVETKQI 9
           CV+TKQI
Sbjct: 294 CVKTKQI 300
>NP_002444
          Length = 727

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           +VC E KQI
Sbjct: 709 IVCYEEKQI 717
>NP_001005369
          Length = 727

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           +VC E KQI
Sbjct: 709 IVCYEEKQI 717
>XP_006712087
          Length = 484

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           +VC E KQI
Sbjct: 466 IVCYEEKQI 474
>XP_005264392
          Length = 727

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           +VC E KQI
Sbjct: 709 IVCYEEKQI 717
>XP_006712086
          Length = 727

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           +VC E KQI
Sbjct: 709 IVCYEEKQI 717
>NP_996879
          Length = 2223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VCVETKQI 9
            +C+E+KQ+
Sbjct: 1742 LCIESKQL 1749
>XP_006720120
          Length = 1055

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVCVETKQ 8
           L+C+ET+Q
Sbjct: 778 LLCLETEQ 785
>XP_006720119
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVCVETKQ 8
           L+C+ET+Q
Sbjct: 817 LLCLETEQ 824
>XP_006710494
          Length = 1152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VCVETKQI 9
           +C+E+KQ+
Sbjct: 671 LCIESKQL 678
>XP_006710492
          Length = 1351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VCVETKQI 9
           +C+E+KQ+
Sbjct: 870 LCIESKQL 877
>XP_006710491
          Length = 1496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VCVETKQI 9
            +C+E+KQ+
Sbjct: 1015 LCIESKQL 1022
>XP_006710490
          Length = 2158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VCVETKQI 9
            +C+E+KQ+
Sbjct: 1677 LCIESKQL 1684
>XP_006710489
          Length = 2185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    VCVETKQI 9
            +C+E+KQ+
Sbjct: 1704 LCIESKQL 1711
>NP_689659
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LVCVETKQ 8
           L+C+ET+Q
Sbjct: 817 LLCLETEQ 824
>NP_775184
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L CVET++
Sbjct: 68 LACVETEE 75
>NP_001241681
          Length = 140

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L C+ET+Q
Sbjct: 124 LNCIETRQ 131
>NP_115945
          Length = 152

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L CVET++
Sbjct: 68 LACVETEE 75
>NP_689562
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CVETKQ 8
           C+ETKQ
Sbjct: 262 CLETKQ 267
>NP_060862
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LVCVETKQI 9
            L CV T+Q+
Sbjct: 2006 LSCVRTRQV 2014
>XP_006716715
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L C+ET+Q
Sbjct: 124 LNCIETRQ 131
>XP_005263172
          Length = 2104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LVCVETKQI 9
            L CV T+Q+
Sbjct: 2006 LSCVRTRQV 2014
>NP_001004749
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   CVETKQI 9
           CV+T+QI
Sbjct: 292 CVKTRQI 298
>NP_001136123
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L+CV+T Q
Sbjct: 406 LLCVDTTQ 413
>NP_115549
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VCVETKQI 9
           VCVET  +
Sbjct: 247 VCVETSNL 254
>NP_689955
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3  CVETKQI 9
          C ET+Q+
Sbjct: 32 CAETRQV 38
>NP_075463
          Length = 3013

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           L+CV  KQ+
Sbjct: 368 LLCVSQKQL 376
>NP_001193927
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VCVETKQI 9
           VCVET  +
Sbjct: 347 VCVETSNL 354
>NP_071338
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VCVETKQ 8
           VCV T+Q
Sbjct: 400 VCVNTRQ 406
>XP_005261831
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VCVETKQI 9
           VCVET  +
Sbjct: 156 VCVETSNL 163
>XP_006724396
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VCVETKQI 9
           VCVET  +
Sbjct: 156 VCVETSNL 163
>XP_005261830
          Length = 836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VCVETKQI 9
           VCVET  +
Sbjct: 247 VCVETSNL 254
>XP_006719812
          Length = 3019

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           L+CV  KQ+
Sbjct: 365 LLCVSQKQL 373
>XP_006717983
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>XP_005270036
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>XP_005270035
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>NP_942090
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LVCVETKQ 8
          L+C +TKQ
Sbjct: 68 LLCEQTKQ 75
>NP_001004485
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           LVCV+T  +
Sbjct: 187 LVCVDTSLV 195
>NP_115785
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   CVETK 7
           CVETK
Sbjct: 549 CVETK 553
>NP_005126
          Length = 1099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 338 VCSKTKEI 345
>NP_598408
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 389 VCSKTKEI 396
>NP_001035959
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 330 VCSKTKEI 337
>NP_001035962
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 374 VCSKTKEI 381
>NP_001035960
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 330 VCSKTKEI 337
>NP_001035961
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 380 VCSKTKEI 387
>NP_079472
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  LVCVETKQ 8
          L+C  TKQ
Sbjct: 26 LLCTATKQ 33
>NP_001035304
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVCVETKQI 9
          LVCV  +QI
Sbjct: 18 LVCVLERQI 26
>NP_699186
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVCVETKQI 9
          LVCV  +QI
Sbjct: 18 LVCVLERQI 26
>NP_006648
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L C+ET+Q
Sbjct: 533 LDCLETRQ 540
>NP_996848
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L C+ET+Q
Sbjct: 533 LDCLETRQ 540
>XP_006726449
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           L+C +TK +
Sbjct: 669 LICQDTKSL 677
>XP_005274666
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CVETKQI 9
           CV+ KQI
Sbjct: 405 CVDQKQI 411
>XP_005274659
          Length = 982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CVETKQI 9
           CV+ KQI
Sbjct: 837 CVDQKQI 843
>XP_006724024
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LVCVETKQ 8
           L C+ET+Q
Sbjct: 576 LDCLETRQ 583
>XP_006720856
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VCVETKQI 9
           VC +TK+I
Sbjct: 340 VCSKTKEI 347
>XP_005266891
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LVCVETKQI 9
          LVCV  +QI
Sbjct: 18 LVCVLERQI 26
>XP_006712222
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LVCVETKQI 9
           L+C +TK +
Sbjct: 669 LICQDTKSL 677
>NP_612157
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VCVETKQI 9
           +C++TK+I
Sbjct: 381 LCLKTKEI 388
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.138    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 666,007
Number of extensions: 879
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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