Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_570711                                                              18    1935
NP_570712                                                              18    1935
NP_570714                                                              18    1935
NP_570713                                                              18    1935
NP_570716                                                              18    1935
NP_000235                                                              18    1935
NP_570715                                                              18    1935
XP_006718620                                                           18    1935
XP_005274059                                                           18    1935
XP_005274060                                                           18    1935
XP_005274058                                                           18    1935
NP_001274141                                                           17    3301
NP_004789                                                              17    3301
NP_008985                                                              17    3301
NP_065867                                                              17    3301
NP_001116291                                                           17    3301
XP_005271926                                                           17    3301
XP_006714589                                                           17    3301
XP_005271925                                                           17    3301
XP_005246008                                                           17    3301
XP_005246007                                                           17    3301
NP_036562                                                              16    5631
NP_065944                                                              15    9605
NP_149053                                                              15    9605
NP_997297                                                              15    9605
>NP_570711
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 565 LVATKINSS 573
>NP_570712
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>NP_570714
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>NP_570713
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>NP_570716
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>NP_000235
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>NP_570715
          Length = 615

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 570 LVATKINSS 578
>XP_006718620
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 565 LVATKINSS 573
>XP_005274059
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 565 LVATKINSS 573
>XP_005274060
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 565 LVATKINSS 573
>XP_005274058
          Length = 610

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVATKIN S
Sbjct: 565 LVATKINSS 573
>NP_001274141
          Length = 929

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 160 ATKINLS 166
>NP_004789
          Length = 747

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 265 ATKINLS 271
>NP_008985
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 270 ATKINLS 276
>NP_065867
          Length = 1029

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 260 ATKINLS 266
>NP_001116291
          Length = 1028

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 260 ATKINLS 266
>XP_005271926
          Length = 702

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 270 ATKINLS 276
>XP_006714589
          Length = 724

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 270 ATKINLS 276
>XP_005271925
          Length = 726

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 270 ATKINLS 276
>XP_005246008
          Length = 984

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 260 ATKINLS 266
>XP_005246007
          Length = 985

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ATKINLS 9
           ATKINLS
Sbjct: 260 ATKINLS 266
>NP_036562
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VATKINLS 9
           ++TKINLS
Sbjct: 132 LSTKINLS 139
>NP_065944
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VATKIN 7
           VATKIN
Sbjct: 901 VATKIN 906
>NP_149053
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LVATKINLS 9
          LVA +IN+S
Sbjct: 63 LVAPEINIS 71
>NP_997297
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LVATKINLS 9
           LVAT +N+S
Sbjct: 813 LVATFLNIS 821
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.127    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 258,341
Number of extensions: 270
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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