Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              21     229
NP_004008                                                              17    4312
NP_004009                                                              17    4312
NP_004007                                                              17    4312
NP_004014                                                              17    4312
NP_004012                                                              17    4312
NP_004004                                                              17    4312
NP_004010                                                              17    4312
NP_004006                                                              17    4312
NP_004013                                                              17    4312
NP_004002                                                              17    4312
NP_004000                                                              17    4312
NP_004001                                                              17    4312
NP_004011                                                              17    4312
NP_003997                                                              17    4312
NP_000100                                                              17    4312
NP_004005                                                              17    4312
NP_004003                                                              17    4312
NP_001123477                                                           17    4312
NP_001123476                                                           17    4312
XP_006724539                                                           17    4312
XP_006724538                                                           17    4312
XP_006724537                                                           17    4312
XP_006724536                                                           17    4312
XP_006724535                                                           17    4312
XP_006724534                                                           17    4312
XP_006724533                                                           17    4312
XP_006724532                                                           17    4312
XP_006724531                                                           17    4312
NP_000531                                                              16    5631
NP_001036188                                                           16    5631
NP_056280                                                              16    5631
NP_001239085                                                           16    5631
XP_006723382                                                           16    5631
XP_006723381                                                           16    5631
XP_006723380                                                           16    5631
NP_000303                                                              16    7355
NP_689844                                                              16    7355
NP_005348                                                              16    7355
XP_005258994                                                           16    7355
XP_006717367                                                           16    7355
XP_006712696                                                           16    7355
XP_005263774                                                           16    7355
XP_005263773                                                           16    7355
XP_005263772                                                           16    7355
NP_003882                                                              15    9605
NP_001243063                                                           15    9605
NP_001013758                                                           15    9605
NP_981953                                                              15    9605
XP_006726595                                                           15    9605
XP_005274478                                                           15    9605
XP_005274477                                                           15    9605
XP_005274475                                                           15    9605
>NP_002430
          Length = 1137

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LVAKGYKMG 9
           LVAKGYK+G
Sbjct: 297 LVAKGYKVG 305
>NP_004008
          Length = 604

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 278 VAKGHKM 284
>NP_004009
          Length = 622

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 278 VAKGHKM 284
>NP_004007
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 278 VAKGHKM 284
>NP_004014
          Length = 1133

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 886 VAKGHKM 892
>NP_004012
          Length = 1243

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 886 VAKGHKM 892
>NP_004004
          Length = 1225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 886 VAKGHKM 892
>NP_004010
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 278 VAKGHKM 284
>NP_004006
          Length = 617

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 278 VAKGHKM 284
>NP_004013
          Length = 1230

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 886 VAKGHKM 892
>NP_004002
          Length = 2344

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 2005 VAKGHKM 2011
>NP_004000
          Length = 3681

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3342 VAKGHKM 3348
>NP_004001
          Length = 3562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3223 VAKGHKM 3229
>NP_004011
          Length = 1115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 886 VAKGHKM 892
>NP_003997
          Length = 3685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>NP_000100
          Length = 3677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3338 VAKGHKM 3344
>NP_004005
          Length = 956

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VAKGYKM 8
           VAKG+KM
Sbjct: 617 VAKGHKM 623
>NP_004003
          Length = 2341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 2002 VAKGHKM 2008
>NP_001123477
          Length = 887

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L++ GY MG
Sbjct: 775 LISMGYNMG 783
>NP_001123476
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L++ GY MG
Sbjct: 802 LISMGYNMG 810
>XP_006724539
          Length = 2913

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 2556 VAKGHKM 2562
>XP_006724538
          Length = 3575

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>XP_006724537
          Length = 3593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>XP_006724536
          Length = 3657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3300 VAKGHKM 3306
>XP_006724535
          Length = 3660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3303 VAKGHKM 3309
>XP_006724534
          Length = 3668

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>XP_006724533
          Length = 3690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>XP_006724532
          Length = 3695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3338 VAKGHKM 3344
>XP_006724531
          Length = 3703

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VAKGYKM 8
            VAKG+KM
Sbjct: 3346 VAKGHKM 3352
>NP_000531
          Length = 5038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVAKGY 6
            LVAKGY
Sbjct: 2313 LVAKGY 2318
>NP_001036188
          Length = 5033

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVAKGY 6
            LVAKGY
Sbjct: 2313 LVAKGY 2318
>NP_056280
          Length = 1508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           LVA GYK G
Sbjct: 166 LVAIGYKDG 174
>NP_001239085
          Length = 1507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           LVA GYK G
Sbjct: 166 LVAIGYKDG 174
>XP_006723382
          Length = 5027

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVAKGY 6
            LVAKGY
Sbjct: 2313 LVAKGY 2318
>XP_006723381
          Length = 5031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVAKGY 6
            LVAKGY
Sbjct: 2312 LVAKGY 2317
>XP_006723380
          Length = 5032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LVAKGY 6
            LVAKGY
Sbjct: 2313 LVAKGY 2318
>NP_000303
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKGYKMG 9
           A GYK+G
Sbjct: 163 APGYKLG 169
>NP_689844
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LVAKGYKM 8
           +++KGY+M
Sbjct: 596 ILSKGYRM 603
>NP_005348
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVAKGYKMG 9
           +VA+G K+G
Sbjct: 253 MVAQGVKLG 261
>XP_005258994
          Length = 1000

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LVAKGYKMG 9
           +VA+G K+G
Sbjct: 253 MVAQGVKLG 261
>XP_006717367
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AKGYKM 8
           AKGYK+
Sbjct: 363 AKGYKL 368
>XP_006712696
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKGYKMG 9
           A GYK+G
Sbjct: 171 APGYKLG 177
>XP_005263774
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKGYKMG 9
           A GYK+G
Sbjct: 184 APGYKLG 190
>XP_005263773
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKGYKMG 9
           A GYK+G
Sbjct: 218 APGYKLG 224
>XP_005263772
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKGYKMG 9
           A GYK+G
Sbjct: 224 APGYKLG 230
>NP_003882
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AKGYKMG 9
           A+GY++G
Sbjct: 153 AQGYRLG 159
>NP_001243063
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   AKGYKMG 9
           A+GY++G
Sbjct: 175 AQGYRLG 181
>NP_001013758
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LVAKGYKM 8
           +++KGY+M
Sbjct: 986 ILSKGYEM 993
>NP_981953
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   LVAKGYKM 8
           +++KGY+M
Sbjct: 743 ILSKGYEM 750
>XP_006726595
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L + GYK+G
Sbjct: 189 LRSNGYKLG 197
>XP_005274478
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L + GYK+G
Sbjct: 189 LRSNGYKLG 197
>XP_005274477
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L + GYK+G
Sbjct: 189 LRSNGYKLG 197
>XP_005274475
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LVAKGYKMG 9
           L + GYK+G
Sbjct: 189 LRSNGYKLG 197
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.142    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,684
Number of extensions: 541
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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