Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              18    1135
XP_005262424                                                           18    1135
NP_006246                                                              16    5631
NP_001265596                                                           16    5631
NP_057361                                                              16    5631
NP_899050                                                              16    5631
NP_001265597                                                           16    5631
NP_001265595                                                           16    5631
XP_005252323                                                           16    5631
XP_005252322                                                           16    5631
XP_005252321                                                           16    5631
XP_005252320                                                           16    5631
XP_006713055                                                           16    5631
NP_001092272                                                           16    5631
NP_115547                                                              16    5631
NP_003310                                                              16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_660337                                                              16    7355
XP_006720926                                                           16    7355
XP_006720925                                                           16    7355
XP_006720924                                                           16    7355
XP_006720923                                                           16    7355
XP_005255218                                                           16    7355
XP_005255217                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_001001389                                                           15    9605
NP_001001390                                                           15    9605
NP_000601                                                              15    9605
NP_001157281                                                           15    9605
NP_001157145                                                           15    9605
NP_689561                                                              15    9605
NP_001157283                                                           15    9605
NP_001138537                                                           15    9605
NP_997374                                                              15    9605
NP_056021                                                              15    9605
NP_443152                                                              15    9605
XP_006720504                                                           15    9605
XP_005253297                                                           15    9605
XP_005253296                                                           15    9605
XP_005253295                                                           15    9605
XP_005253292                                                           15    9605
XP_005253291                                                           15    9605
XP_005253290                                                           15    9605
XP_006718452                                                           15    9605
XP_006718451                                                           15    9605
XP_005253289                                                           15    9605
XP_005253288                                                           15    9605
XP_006711992                                                           15    9605
>NP_722576
          Length = 3080

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSSNRVGV 9
            LTSSN VGV
Sbjct: 1343 LTSSNTVGV 1351
>XP_005262424
          Length = 2875

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSSNRVGV 9
            LTSSN VGV
Sbjct: 1138 LTSSNTVGV 1146
>NP_006246
          Length = 683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTSSNRVGV 9
           + SSNR+G+
Sbjct: 344 VNSSNRLGI 352
>NP_001265596
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSSNRVGV 9
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_057361
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSSNRVGV 9
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_899050
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSSNRVGV 9
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_001265597
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSSNRVGV 9
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>NP_001265595
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TSSNRVGV 9
           +SSN++GV
Sbjct: 186 SSSNKIGV 193
>XP_005252323
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 558 TSSNNLGV 565
>XP_005252322
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 629 TSSNNLGV 636
>XP_005252321
          Length = 696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 619 TSSNNLGV 626
>XP_005252320
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 645 TSSNNLGV 652
>XP_006713055
          Length = 195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSSNRVGV 9
           +TSS R GV
Sbjct: 122 ITSSTRTGV 130
>NP_001092272
          Length = 722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 645 TSSNNLGV 652
>NP_115547
          Length = 706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSN +GV
Sbjct: 629 TSSNNLGV 636
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTSSNRVG 8
            +T+SNR+G
Sbjct: 8980 VTASNRLG 8987
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTSSNRVG 8
            +T+SNR+G
Sbjct: 9105 VTASNRLG 9112
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1     LTSSNRVG 8
             +T+SNR+G
Sbjct: 16404 VTASNRLG 16411
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1     LTSSNRVG 8
             +T+SNR+G
Sbjct: 15477 VTASNRLG 15484
>NP_660337
          Length = 1748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 904 TSSNRVVV 911
>XP_006720926
          Length = 1383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_006720925
          Length = 1674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_006720924
          Length = 1679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 833 TSSNRVVV 840
>XP_006720923
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_005255218
          Length = 1750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 904 TSSNRVVV 911
>XP_005255217
          Length = 1751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           TSSNRV V
Sbjct: 905 TSSNRVVV 912
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTSSNRVG 8
            +T+SNR+G
Sbjct: 4717 VTASNRLG 4724
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTSSNRVG 8
            +T+SNR+G
Sbjct: 6076 VTASNRLG 6083
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1     LTSSNRVG 8
             +T+SNR+G
Sbjct: 16032 VTASNRLG 16039
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1     LTSSNRVG 8
             +T+SNR+G
Sbjct: 17538 VTASNRLG 17545
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1     LTSSNRVG 8
             +T+SNR+G
Sbjct: 18045 VTASNRLG 18052
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTSSNRVG 8
            +T+SNR+G
Sbjct: 9172 VTASNRLG 9179
>NP_001001389
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 489 LTSSNR 494
>NP_001001390
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 283 LTSSNR 288
>NP_000601
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 532 LTSSNR 537
>NP_001157281
          Length = 1941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TSSNRVGV 9
            T SN++GV
Sbjct: 1886 TVSNKIGV 1893
>NP_001157145
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           T SN++GV
Sbjct: 683 TVSNKIGV 690
>NP_689561
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           T SN++GV
Sbjct: 835 TVSNKIGV 842
>NP_001157283
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSSNRVGV 9
           T SN++GV
Sbjct: 659 TVSNKIGV 666
>NP_001138537
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TSSNRVGV 9
          +SSN VGV
Sbjct: 34 SSSNTVGV 41
>NP_997374
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TSSNRVGV 9
          +SSN VGV
Sbjct: 34 SSSNTVGV 41
>NP_056021
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTSSNRVGV 9
           +T +NRVG+
Sbjct: 736 ITYTNRVGL 744
>NP_443152
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTSSNRVGV 9
           LT+SN +GV
Sbjct: 431 LTASNCLGV 439
>XP_006720504
          Length = 831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTSSNRVGV 9
           +T +NRVG+
Sbjct: 736 ITYTNRVGL 744
>XP_005253297
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 325 LTSSNR 330
>XP_005253296
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 368 LTSSNR 373
>XP_005253295
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 370 LTSSNR 375
>XP_005253292
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 490 LTSSNR 495
>XP_005253291
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 492 LTSSNR 497
>XP_005253290
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 493 LTSSNR 498
>XP_006718452
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 525 LTSSNR 530
>XP_006718451
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 531 LTSSNR 536
>XP_005253289
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 532 LTSSNR 537
>XP_005253288
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTSSNR 6
           LTSSNR
Sbjct: 533 LTSSNR 538
>XP_006711992
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTSSNRVGV 9
           LT+SN +GV
Sbjct: 431 LTASNCLGV 439
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.122    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 344,884
Number of extensions: 400
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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