Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001073883                                                           19     665
XP_005267748                                                           19     665
NP_000258                                                              19     869
NP_001035957                                                           19     869
XP_006721990                                                           19     869
XP_006721989                                                           19     869
XP_005258041                                                           19     869
XP_006721988                                                           19     869
XP_006721987                                                           19     869
XP_006721986                                                           19     869
XP_005258040                                                           19     869
XP_006721985                                                           19     869
NP_001172003                                                           17    2528
NP_001171988                                                           17    2528
NP_078893                                                              17    2528
XP_006717349                                                           17    2528
XP_005252266                                                           17    2528
XP_005252265                                                           17    2528
XP_005252264                                                           17    2528
XP_006717348                                                           17    2528
XP_006717347                                                           17    2528
XP_006717346                                                           17    2528
XP_006710300                                                           17    4312
NP_000532                                                              16    5631
NP_065910                                                              16    5631
NP_060594                                                              16    5631
XP_006721290                                                           16    5631
XP_005256079                                                           16    5631
XP_005256078                                                           16    5631
XP_005263222                                                           16    5631
XP_005263221                                                           16    5631
XP_005263220                                                           16    5631
XP_006714345                                                           16    5631
XP_005263219                                                           16    5631
XP_005246157                                                           16    5631
XP_005246156                                                           16    5631
NP_002408                                                              16    7355
NP_001139438                                                           16    7355
NP_005364                                                              16    7355
NP_056073                                                              16    7355
XP_006717927                                                           16    7355
XP_006717082                                                           16    7355
XP_006717081                                                           16    7355
NP_006531                                                              15    9605
NP_001274152                                                           15    9605
NP_775894                                                              15    9605
NP_001124390                                                           15    9605
NP_054858                                                              15    9605
XP_006721892                                                           15    9605
XP_006721891                                                           15    9605
XP_006721890                                                           15    9605
XP_005251190                                                           15    9605
XP_005251188                                                           15    9605
XP_005251189                                                           15    9605
XP_005251187                                                           15    9605
XP_005251186                                                           15    9605
XP_005251185                                                           15    9605
NP_060469                                                              15    9605
>NP_001073883
          Length = 2028

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTSLETATE 9
           +TSLETATE
Sbjct: 651 VTSLETATE 659
>XP_005267748
          Length = 1535

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTSLETATE 9
           +TSLETATE
Sbjct: 651 VTSLETATE 659
>NP_000258
          Length = 2818

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2178 LTSLETVTE 2186
>NP_001035957
          Length = 2839

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2199 LTSLETVTE 2207
>XP_006721990
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2209 LTSLETVTE 2217
>XP_006721989
          Length = 2823

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2209 LTSLETVTE 2217
>XP_005258041
          Length = 2836

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2178 LTSLETVTE 2186
>XP_006721988
          Length = 2846

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2188 LTSLETVTE 2196
>XP_006721987
          Length = 2849

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2209 LTSLETVTE 2217
>XP_006721986
          Length = 2854

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2196 LTSLETVTE 2204
>XP_005258040
          Length = 2857

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2199 LTSLETVTE 2207
>XP_006721985
          Length = 2867

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LTSLETATE 9
            LTSLET TE
Sbjct: 2209 LTSLETVTE 2217
>NP_001172003
          Length = 1259

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>NP_001171988
          Length = 1495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>NP_078893
          Length = 1495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_006717349
          Length = 1046

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_005252266
          Length = 1046

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_005252265
          Length = 1381

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_005252264
          Length = 1478

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_006717348
          Length = 1541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_006717347
          Length = 1541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_006717346
          Length = 1541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSLET +E
Sbjct: 159 LTSLETTSE 167
>XP_006710300
          Length = 1116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LTSLETATE 9
           LTSL T+TE
Sbjct: 475 LTSLVTSTE 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TSLETATE 9
           TSL TATE
Sbjct: 340 TSLITATE 347
>NP_000532
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS E ATE
Sbjct: 346 LTSSEVATE 354
>NP_065910
          Length = 1996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 367 SSLETATD 374
>NP_060594
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           LTSLET T
Sbjct: 524 LTSLETNT 531
>XP_006721290
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           LTSLET T
Sbjct: 524 LTSLETNT 531
>XP_005256079
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           LTSLET T
Sbjct: 524 LTSLETNT 531
>XP_005256078
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           LTSLET T
Sbjct: 524 LTSLETNT 531
>XP_005263222
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 191 SSLETATD 198
>XP_005263221
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 191 SSLETATD 198
>XP_005263220
          Length = 1820

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 191 SSLETATD 198
>XP_006714345
          Length = 1961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 332 SSLETATD 339
>XP_005263219
          Length = 1996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   TSLETATE 9
           +SLETAT+
Sbjct: 367 SSLETATD 374
>XP_005246157
          Length = 239

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS E ATE
Sbjct: 212 LTSSEVATE 220
>XP_005246156
          Length = 405

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS E ATE
Sbjct: 346 LTSSEVATE 354
>NP_002408
          Length = 3256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           +TSLET T
Sbjct: 851 MTSLETKT 858
>NP_001139438
          Length = 2896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LTSLETAT 8
           +TSLET T
Sbjct: 491 MTSLETKT 498
>NP_005364
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TSLETATE 9
           T +ETATE
Sbjct: 481 TRVETATE 488
>NP_056073
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLETATE 9
           SL+TATE
Sbjct: 619 SLQTATE 625
>XP_006717927
          Length = 2406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 LTSLETAT 8
         +TSLET T
Sbjct: 1 MTSLETKT 8
>XP_006717082
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLETATE 9
           SL+TATE
Sbjct: 551 SLQTATE 557
>XP_006717081
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLETATE 9
           SL+TATE
Sbjct: 619 SLQTATE 625
>NP_006531
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>NP_001274152
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTSLETA 7
           LTSLET+
Sbjct: 445 LTSLETS 451
>NP_775894
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS+ET  E
Sbjct: 375 LTSVETTPE 383
>NP_001124390
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS+ET  E
Sbjct: 682 LTSVETTPE 690
>NP_054858
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LTSLETA 7
           LTSLET+
Sbjct: 445 LTSLETS 451
>XP_006721892
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS+ET  E
Sbjct: 634 LTSVETTPE 642
>XP_006721891
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS+ET  E
Sbjct: 682 LTSVETTPE 690
>XP_006721890
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTSLETATE 9
           LTS+ET  E
Sbjct: 682 LTSVETTPE 690
>XP_005251190
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>XP_005251188
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>XP_005251189
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>XP_005251187
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>XP_005251186
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>XP_005251185
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTSLETAT 8
           +TSL+T+T
Sbjct: 280 ITSLDTST 287
>NP_060469
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LETATE 9
            LETATE
Sbjct: 1026 LETATE 1031
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.288    0.103    0.226 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 276,926
Number of extensions: 365
Number of successful extensions: 59
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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