Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138390                                                           21     175
NP_001138386                                                           21     175
NP_001138387                                                           21     175
NP_000132                                                              21     175
NP_075259                                                              21     175
NP_001138388                                                           21     175
NP_001138391                                                           21     175
NP_001138385                                                           21     175
NP_075418                                                              21     175
XP_006717776                                                           21     175
XP_006717775                                                           21     175
XP_006717774                                                           21     175
XP_006717773                                                           21     175
XP_006717772                                                           21     175
XP_006717771                                                           21     175
NP_945193                                                              17    4312
NP_001019833                                                           16    5631
NP_000961                                                              16    5631
NP_001901                                                              16    5631
NP_683865                                                              16    5631
NP_001268997                                                           16    5631
NP_001268991                                                           16    5631
NP_003577                                                              16    5631
NP_001268992                                                           16    5631
XP_006721162                                                           16    5631
XP_006721161                                                           16    5631
XP_005255692                                                           16    5631
XP_006721160                                                           16    5631
XP_005253977                                                           16    5631
XP_006719612                                                           16    5631
XP_006719611                                                           16    5631
XP_006719610                                                           16    5631
XP_006719609                                                           16    5631
NP_878315                                                              16    7355
NP_699165                                                              16    7355
NP_001185882                                                           16    7355
NP_057204                                                              16    7355
NP_899196                                                              16    7355
NP_722576                                                              16    7355
NP_068593                                                              16    7355
NP_076976                                                              16    7355
XP_005262424                                                           16    7355
XP_006724427                                                           16    7355
XP_005255372                                                           16    7355
XP_005267358                                                           16    7355
XP_006720081                                                           16    7355
XP_006720080                                                           16    7355
NP_001360                                                              15    9605
NP_000050                                                              15    9605
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_001243757                                                           15    9605
NP_001269255                                                           15    9605
NP_001243756                                                           15    9605
NP_060045                                                              15    9605
NP_055642                                                              15    9605
NP_006350                                                              15    9605
NP_001036002                                                           15    9605
XP_005256628                                                           15    9605
XP_006721556                                                           15    9605
XP_005256626                                                           15    9605
XP_005248319                                                           15    9605
XP_005245703                                                           15    9605
XP_006711736                                                           15    9605
XP_005245701                                                           15    9605
XP_005245700                                                           15    9605
NP_001005174                                                           15    9605
>NP_001138390
          Length = 704

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 303 LTKRIPLRR 311
>NP_001138386
          Length = 709

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 306 LTKRIPLRR 314
>NP_001138387
          Length = 707

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 329 LTKRIPLRR 337
>NP_000132
          Length = 821

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 418 LTKRIPLRR 426
>NP_075259
          Length = 822

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 419 LTKRIPLRR 427
>NP_001138388
          Length = 706

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 303 LTKRIPLRR 311
>NP_001138391
          Length = 680

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 330 LTKRIPLRR 338
>NP_001138385
          Length = 769

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 419 LTKRIPLRR 427
>NP_075418
          Length = 732

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 329 LTKRIPLRR 337
>XP_006717776
          Length = 806

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 437 LTKRIPLRR 445
>XP_006717775
          Length = 726

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 323 LTKRIPLRR 331
>XP_006717774
          Length = 752

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 349 LTKRIPLRR 357
>XP_006717773
          Length = 807

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 438 LTKRIPLRR 446
>XP_006717772
          Length = 838

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 437 LTKRIPLRR 445
>XP_006717771
          Length = 839

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRVPLRR 9
           LTKR+PLRR
Sbjct: 438 LTKRIPLRR 446
>NP_945193
          Length = 801

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTKRVPLRR 9
          LT+ +PLRR
Sbjct: 26 LTRLLPLRR 34
>NP_001019833
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>NP_000961
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>NP_001901
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RVPLRR 9
          RVPLRR
Sbjct: 23 RVPLRR 28
>NP_683865
          Length = 363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RVPLRR 9
          RVPLRR
Sbjct: 23 RVPLRR 28
>NP_001268997
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>NP_001268991
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>NP_003577
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>NP_001268992
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>XP_006721162
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RVPLRR 9
          RVPLRR
Sbjct: 77 RVPLRR 82
>XP_006721161
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>XP_005255692
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>XP_006721160
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 195 RVPLRR 200
>XP_005253977
          Length = 177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  RVPLRR 9
          RVPLRR
Sbjct: 72 RVPLRR 77
>XP_006719612
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>XP_006719611
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>XP_006719610
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>XP_006719609
          Length = 288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           RVPLRR
Sbjct: 183 RVPLRR 188
>NP_878315
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           R+PLRR
Sbjct: 501 RIPLRR 506
>NP_699165
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           R+PLRR
Sbjct: 506 RIPLRR 511
>NP_001185882
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  TKRVPLRR 9
          +++VPLRR
Sbjct: 79 SQKVPLRR 86
>NP_057204
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKRVPLRR 9
           T R+P+RR
Sbjct: 381 TIRIPIRR 388
>NP_899196
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKRVPLRR 9
           T R+P+RR
Sbjct: 381 TIRIPIRR 388
>NP_722576
          Length = 3080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LTKRVPL 7
            LT+R+PL
Sbjct: 2613 LTERIPL 2619
>NP_068593
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TKRVPLRR 9
           T R PLRR
Sbjct: 209 TDRCPLRR 216
>NP_076976
          Length = 234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  TKRVPLRR 9
          +++VPLRR
Sbjct: 79 SQKVPLRR 86
>XP_005262424
          Length = 2875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LTKRVPL 7
            LT+R+PL
Sbjct: 2408 LTERIPL 2414
>XP_006724427
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RVPLRR 9
           R+PLRR
Sbjct: 501 RIPLRR 506
>XP_005255372
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LTKRVPLRR 9
          L + VPLRR
Sbjct: 24 LLEEVPLRR 32
>XP_005267358
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRVPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>XP_006720081
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRVPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>XP_006720080
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRVPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LTKRVPLRR 9
            +TK VPL R
Sbjct: 2763 VTKLVPLTR 2771
>NP_000050
          Length = 3418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LTKRVPLRR 9
           LTK +P+ +
Sbjct: 809 LTKNIPMEK 817
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LTKRVPLRR 9
            L+ +VPL+R
Sbjct: 3151 LSSQVPLKR 3159
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LTKRVPLRR 9
            L+ +VPL+R
Sbjct: 3151 LSSQVPLKR 3159
>NP_001243757
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>NP_001269255
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LT+ VP+R
Sbjct: 311 LTRNVPVR 318
>NP_001243756
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>NP_060045
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LTKRVPLR 8
            LT+ VP+R
Sbjct: 1400 LTRNVPVR 1407
>NP_055642
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>NP_006350
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KRVPLRR 9
          +R PLRR
Sbjct: 7  RRAPLRR 13
>NP_001036002
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KRVPLRR 9
          +R PLRR
Sbjct: 7  RRAPLRR 13
>XP_005256628
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>XP_006721556
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LTKRVPLR 8
            LT+ VP+R
Sbjct: 1338 LTRNVPVR 1345
>XP_005256626
          Length = 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LTKRVPLR 8
            LT+ VP+R
Sbjct: 1369 LTRNVPVR 1376
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LTKRVPLRR 9
            +TK VPL R
Sbjct: 2748 VTKLVPLTR 2756
>XP_005245703
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LTKR+P +
Sbjct: 272 LTKRLPTK 279
>XP_006711736
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245701
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245700
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRVPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>NP_001005174
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTKRVPLRR 9
           LTKR+P  R
Sbjct: 164 LTKRLPYCR 172
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.147    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 580,941
Number of extensions: 789
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package