Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138390                                                           20     299
NP_001138386                                                           20     299
NP_001138387                                                           20     299
NP_000132                                                              20     299
NP_075259                                                              20     299
NP_001138388                                                           20     299
NP_001138391                                                           20     299
NP_001138385                                                           20     299
NP_075418                                                              20     299
XP_006717776                                                           20     299
XP_006717775                                                           20     299
XP_006717774                                                           20     299
XP_006717773                                                           20     299
XP_006717772                                                           20     299
XP_006717771                                                           20     299
NP_945193                                                              17    3301
NP_031384                                                              16    5631
NP_001012418                                                           16    5631
NP_071919                                                              16    5631
NP_001243479                                                           16    5631
NP_001157864                                                           16    5631
XP_005268060                                                           16    5631
XP_005267358                                                           16    5631
XP_006720081                                                           16    5631
XP_006720080                                                           16    5631
XP_005249137                                                           16    5631
XP_006715145                                                           16    5631
XP_006715144                                                           16    5631
XP_005249136                                                           16    5631
XP_005249134                                                           16    5631
XP_005249135                                                           16    5631
NP_055642                                                              16    7355
NP_068593                                                              16    7355
XP_005245703                                                           16    7355
XP_006711736                                                           16    7355
XP_005245701                                                           16    7355
XP_005245700                                                           16    7355
NP_001005174                                                           16    7355
NP_001189489                                                           15    9605
NP_694540                                                              15    9605
NP_996744                                                              15    9605
NP_008928                                                              15    9605
NP_542780                                                              15    9605
NP_996742                                                              15    9605
NP_001265552                                                           15    9605
NP_001265553                                                           15    9605
XP_006722986                                                           15    9605
XP_005268911                                                           15    9605
XP_006717618                                                           15    9605
XP_005269456                                                           15    9605
XP_006717617                                                           15    9605
XP_006717616                                                           15    9605
XP_006717615                                                           15    9605
XP_005269454                                                           15    9605
XP_005269453                                                           15    9605
XP_006717614                                                           15    9605
XP_006717613                                                           15    9605
XP_006717612                                                           15    9605
XP_005269452                                                           15    9605
XP_005269451                                                           15    9605
XP_006717611                                                           15    9605
XP_005269450                                                           15    9605
XP_005269449                                                           15    9605
XP_005269448                                                           15    9605
XP_005269447                                                           15    9605
XP_005269446                                                           15    9605
XP_005269445                                                           15    9605
XP_006715409                                                           15    9605
NP_996743                                                              15    9605
NP_001001913                                                           15    9605
NP_940942                                                              15    9605
>NP_001138390
          Length = 704

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 303 LTKRIPLRR 311
>NP_001138386
          Length = 709

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 306 LTKRIPLRR 314
>NP_001138387
          Length = 707

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 329 LTKRIPLRR 337
>NP_000132
          Length = 821

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 418 LTKRIPLRR 426
>NP_075259
          Length = 822

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 419 LTKRIPLRR 427
>NP_001138388
          Length = 706

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 303 LTKRIPLRR 311
>NP_001138391
          Length = 680

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 330 LTKRIPLRR 338
>NP_001138385
          Length = 769

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 419 LTKRIPLRR 427
>NP_075418
          Length = 732

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 329 LTKRIPLRR 337
>XP_006717776
          Length = 806

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 437 LTKRIPLRR 445
>XP_006717775
          Length = 726

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 323 LTKRIPLRR 331
>XP_006717774
          Length = 752

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 349 LTKRIPLRR 357
>XP_006717773
          Length = 807

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 438 LTKRIPLRR 446
>XP_006717772
          Length = 838

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 437 LTKRIPLRR 445
>XP_006717771
          Length = 839

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LTKRMPLRR 9
           LTKR+PLRR
Sbjct: 438 LTKRIPLRR 446
>NP_945193
          Length = 801

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTKRMPLRR 9
          LT+ +PLRR
Sbjct: 26 LTRLLPLRR 34
>NP_031384
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KRMPLRR 9
          KR PLRR
Sbjct: 14 KRSPLRR 20
>NP_001012418
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>NP_071919
          Length = 675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TKRMPLRR 9
          T+ MP+RR
Sbjct: 45 TRMMPIRR 52
>NP_001243479
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TKRMPLRR 9
          T+ MP+RR
Sbjct: 11 TRMMPIRR 18
>NP_001157864
          Length = 536

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KRMPLRR 9
          KR PLRR
Sbjct: 14 KRSPLRR 20
>XP_005268060
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TKRMPLRR 9
          T+ MP+RR
Sbjct: 11 TRMMPIRR 18
>XP_005267358
          Length = 777

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRMPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>XP_006720081
          Length = 795

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRMPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>XP_006720080
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TKRMPLRR 9
           ++R+PLRR
Sbjct: 549 SERLPLRR 556
>XP_005249137
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>XP_006715145
          Length = 382

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 57 LTERMPVK 64
>XP_006715144
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>XP_005249136
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>XP_005249134
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>XP_005249135
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  LTKRMPLR 8
          LT+RMP++
Sbjct: 63 LTERMPVK 70
>NP_055642
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRMPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>NP_068593
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TKRMPLRR 9
           T R PLRR
Sbjct: 209 TDRCPLRR 216
>XP_005245703
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRMPLR 8
           LTKR+P +
Sbjct: 272 LTKRLPTK 279
>XP_006711736
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRMPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245701
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRMPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245700
          Length = 810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LTKRMPLR 8
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>NP_001005174
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTKRMPLRR 9
           LTKR+P  R
Sbjct: 164 LTKRLPYCR 172
>NP_001189489
          Length = 298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TKRMPLR 8
           T+R PLR
Sbjct: 249 TRRFPLR 255
>NP_694540
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TKRMPLRR 9
           TKRMP  +
Sbjct: 455 TKRMPCHK 462
>NP_996744
          Length = 2948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2296 KMPLRR 2301
>NP_008928
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RMPLRR 9
           +MPLRR
Sbjct: 374 KMPLRR 379
>NP_542780
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RMPLRR 9
          R+PLRR
Sbjct: 51 RLPLRR 56
>NP_996742
          Length = 996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RMPLRR 9
           +MPLRR
Sbjct: 374 KMPLRR 379
>NP_001265552
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TKRMPLRR 9
           TKRMP  +
Sbjct: 455 TKRMPCHK 462
>NP_001265553
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TKRMPLRR 9
           TKRMP  +
Sbjct: 455 TKRMPCHK 462
>XP_006722986
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  KRMPLRR 9
          +R PLRR
Sbjct: 14 RRFPLRR 20
>XP_005268911
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   TKRMPLRR 9
           ++R+P+RR
Sbjct: 538 SERLPIRR 545
>XP_006717618
          Length = 2826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2251 KMPLRR 2256
>XP_005269456
          Length = 2846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2271 KMPLRR 2276
>XP_006717617
          Length = 2887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_006717616
          Length = 2891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_006717615
          Length = 2903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269454
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2229 KMPLRR 2234
>XP_005269453
          Length = 2922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_006717614
          Length = 2938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_006717613
          Length = 2948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2296 KMPLRR 2301
>XP_006717612
          Length = 2950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269452
          Length = 2954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2271 KMPLRR 2276
>XP_005269451
          Length = 2957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2274 KMPLRR 2279
>XP_006717611
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269450
          Length = 2968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269449
          Length = 2969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269448
          Length = 2979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2296 KMPLRR 2301
>XP_005269447
          Length = 2980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269446
          Length = 2999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_005269445
          Length = 2999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RMPLRR 9
            +MPLRR
Sbjct: 2316 KMPLRR 2321
>XP_006715409
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RMPLRR 9
          R+PLRR
Sbjct: 51 RLPLRR 56
>NP_996743
          Length = 1094

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RMPLRR 9
           +MPLRR
Sbjct: 442 KMPLRR 447
>NP_001001913
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LTKRMP 6
           LTKR+P
Sbjct: 164 LTKRLP 169
>NP_940942
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TKRMPLRR 9
           T+ MPLR+
Sbjct: 278 TQAMPLRK 285
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.145    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 583,758
Number of extensions: 871
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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