Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001005340                                                           17    4312
NP_002501                                                              17    4312
XP_005249635                                                           17    4312
NP_001274734                                                           16    5631
NP_004637                                                              16    5631
NP_001020787                                                           16    5631
XP_005263320                                                           16    5631
NP_112595                                                              16    5631
NP_001036134                                                           16    5631
NP_001003684                                                           16    7355
NP_037519                                                              16    7355
NP_002323                                                              15    9605
NP_000391                                                              15    9605
NP_056163                                                              15    9605
NP_001002026                                                           15    9605
NP_114141                                                              15    9605
XP_005258696                                                           15    9605
XP_005263969                                                           15    9605
XP_005263968                                                           15    9605
XP_005263967                                                           15    9605
XP_005263966                                                           15    9605
NP_057453                                                              15    9605



>NP_001005340
          Length = 572

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTIVEGVM 8
           +TIVEG++
Sbjct: 381 ITIVEGIL 388





>NP_002501
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTIVEGVM 8
           +TIVEG++
Sbjct: 369 ITIVEGIL 376





>XP_005249635
          Length = 531

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTIVEGVM 8
           +TIVEG++
Sbjct: 381 ITIVEGIL 388





>NP_001274734
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LTI+EG +V
Sbjct: 220 LTIMEGTVV 228





>NP_004637
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LTIVEGVMV 9
          LT+VEG  V
Sbjct: 41 LTVVEGASV 49





>NP_001020787
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LTI+EG +V
Sbjct: 305 LTIMEGTVV 313





>XP_005263320
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LTI+EG +V
Sbjct: 305 LTIMEGTVV 313





>NP_112595
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LTI+EG +V
Sbjct: 212 LTIMEGTVV 220





>NP_001036134
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LTI+EG +V
Sbjct: 210 LTIMEGTVV 218





>NP_001003684
          Length = 62

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LTIVEGVM 8
          LTI+ GVM
Sbjct: 23 LTIIVGVM 30





>NP_037519
          Length = 63

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LTIVEGVM 8
          LTI+ GVM
Sbjct: 23 LTIIVGVM 30





>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   TIVEGVMV 9
           TI++G+++
Sbjct: 403 TIIQGILI 410





>NP_000391
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIVEGVMV 9
           LT+ EGV V
Sbjct: 708 LTVDEGVQV 716





>NP_056163
          Length = 1883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT+++ VMV
Sbjct: 960 LTVMDAVMV 968





>NP_001002026
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT++ GVM+
Sbjct: 184 LTLIGGVMM 192





>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LTIVEGVMV 9
            LT++EG ++
Sbjct: 2206 LTVIEGNLI 2214





>XP_005258696
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LTIVEGVMV 9
           LT+ EGV V
Sbjct: 684 LTVDEGVQV 692





>XP_005263969
          Length = 1844

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT+++ VMV
Sbjct: 921 LTVMDAVMV 929





>XP_005263968
          Length = 1861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT+++ VMV
Sbjct: 938 LTVMDAVMV 946





>XP_005263967
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT+++ VMV
Sbjct: 977 LTVMDAVMV 985





>XP_005263966
          Length = 1900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT+++ VMV
Sbjct: 977 LTVMDAVMV 985





>NP_057453
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTIVEGVMV 9
           LT++ GVM+
Sbjct: 184 LTLIGGVMM 192





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.147    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 422,539
Number of extensions: 449
Number of successful extensions: 22
Number of sequences better than 10000.0: 22
Number of HSP's gapped: 22
Number of HSP's successfully gapped: 22
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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