Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           19     869
NP_060785                                                              19     869
NP_361014                                                              19     869
NP_001080                                                              18    1935
NP_001269645                                                           17    4312
NP_036579                                                              17    4312
NP_001269646                                                           17    4312
NP_001269647                                                           17    4312
NP_001361                                                              17    4312
XP_005250173                                                           17    4312
XP_006712019                                                           17    4312
NP_848599                                                              16    5631
NP_001157164                                                           16    5631
NP_001004341                                                           16    5631
XP_005254427                                                           16    5631
XP_006713081                                                           16    5631
NP_001271427                                                           16    7355
NP_689559                                                              16    7355
NP_001269462                                                           16    7355
NP_001271428                                                           16    7355
NP_001185739                                                           16    7355
NP_085116                                                              16    7355
NP_003618                                                              16    7355
NP_000005                                                              16    7355
NP_055199                                                              16    7355
XP_005260950                                                           16    7355
XP_005260949                                                           16    7355
XP_005260948                                                           16    7355
XP_005260947                                                           16    7355
XP_006721509                                                           16    7355
XP_006721508                                                           16    7355
XP_006721507                                                           16    7355
XP_006720053                                                           16    7355
XP_005272473                                                           16    7355
XP_006720052                                                           16    7355
XP_006720051                                                           16    7355
XP_006720050                                                           16    7355
XP_006720048                                                           16    7355
XP_005272471                                                           16    7355
XP_006720047                                                           16    7355
XP_006720045                                                           16    7355
XP_006719119                                                           16    7355
XP_005271562                                                           16    7355
XP_005271558                                                           16    7355
XP_005274415                                                           16    7355
XP_005274414                                                           16    7355
NP_001108451                                                           15    9605
NP_001108454                                                           15    9605
NP_003713                                                              15    9605
NP_001108450                                                           15    9605
NP_001108452                                                           15    9605
NP_001108453                                                           15    9605
NP_071750                                                              15    9605
XP_005256148                                                           15    9605
XP_006721307                                                           15    9605
XP_005256144                                                           15    9605
XP_005256143                                                           15    9605
XP_005256142                                                           15    9605
XP_005247903                                                           15    9605
XP_005247901                                                           15    9605
XP_005247900                                                           15    9605
XP_005273100                                                           15    9605
XP_006711797                                                           15    9605
XP_005273098                                                           15    9605
NP_444280                                                              15    9605
>NP_001013433
          Length = 589

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           LTG QSLTS
Sbjct: 459 LTGHQSLTS 467
>NP_060785
          Length = 627

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           LTG QSLTS
Sbjct: 497 LTGHQSLTS 505
>NP_361014
          Length = 707

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           LTG QSLTS
Sbjct: 577 LTGHQSLTS 585
>NP_001080
          Length = 1704

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LTGRQSLTS 9
            LTG +SLTS
Sbjct: 1429 LTGEESLTS 1437
>NP_001269645
          Length = 1225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           +TGR+ LTS
Sbjct: 555 VTGRKGLTS 563
>NP_036579
          Length = 1225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           +TGR+ LTS
Sbjct: 555 VTGRKGLTS 563
>NP_001269646
          Length = 1226

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           +TGR+ LTS
Sbjct: 555 VTGRKGLTS 563
>NP_001269647
          Length = 1167

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           +TGR+ LTS
Sbjct: 497 VTGRKGLTS 505
>NP_001361
          Length = 4158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TGRQSLT 8
            TG+QSLT
Sbjct: 2451 TGKQSLT 2457
>XP_005250173
          Length = 1222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LTGRQSLTS 9
           +TGR+ LTS
Sbjct: 555 VTGRKGLTS 563
>XP_006712019
          Length = 4158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TGRQSLT 8
            TG+QSLT
Sbjct: 2451 TGKQSLT 2457
>NP_848599
          Length = 3092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TGRQSLT 8
            +GRQSLT
Sbjct: 2261 SGRQSLT 2267
>NP_001157164
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TGRQSLT 8
           TGRQSL+
Sbjct: 296 TGRQSLS 302
>NP_001004341
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           TG +SLTS
Sbjct: 339 TGEESLTS 346
>XP_005254427
          Length = 381

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TGRQSLT 8
           TGRQSL+
Sbjct: 296 TGRQSLS 302
>XP_006713081
          Length = 3964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    TGRQSLT 8
            +GRQSLT
Sbjct: 2284 SGRQSLT 2290
>NP_001271427
          Length = 573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 488 LTGLQSLIS 496
>NP_689559
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 484 LTGLQSLIS 492
>NP_001269462
          Length = 627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           +GR SLTS
Sbjct: 219 SGRNSLTS 226
>NP_001271428
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 347 LTGLQSLIS 355
>NP_001185739
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 479 LTGLQSLIS 487
>NP_085116
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TGRQSLT 8
           TGR SLT
Sbjct: 364 TGRSSLT 370
>NP_003618
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 479 LTGLQSLIS 487
>NP_000005
          Length = 1474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTGRQS 6
           LTGRQS
Sbjct: 335 LTGRQS 340
>NP_055199
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TGRQSLTS 9
          TG +SLTS
Sbjct: 26 TGHRSLTS 33
>XP_005260950
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           +GR SLTS
Sbjct: 219 SGRNSLTS 226
>XP_005260949
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           +GR SLTS
Sbjct: 219 SGRNSLTS 226
>XP_005260948
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           +GR SLTS
Sbjct: 249 SGRNSLTS 256
>XP_005260947
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TGRQSLTS 9
           +GR SLTS
Sbjct: 249 SGRNSLTS 256
>XP_006721509
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 451 LTGLQSLIS 459
>XP_006721508
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 484 LTGLQSLIS 492
>XP_006721507
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 484 LTGLQSLIS 492
>XP_006720053
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_005272473
          Length = 186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720052
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720051
          Length = 188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720050
          Length = 195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720048
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_005272471
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720047
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006720045
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          L GR++LTS
Sbjct: 3  LRGRKNLTS 11
>XP_006719119
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LTGRQS 6
           LTGRQS
Sbjct: 335 LTGRQS 340
>XP_005271562
          Length = 249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TGRQSLTS 9
          TG +SLTS
Sbjct: 26 TGHRSLTS 33
>XP_005271558
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TGRQSLTS 9
          TG +SLTS
Sbjct: 26 TGHRSLTS 33
>XP_005274415
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 495 LTGLQSLIS 503
>XP_005274414
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           LTG QSL S
Sbjct: 505 LTGLQSLIS 513
>NP_001108451
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 280 ITGRQSV 286
>NP_001108454
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 186 ITGRQSV 192
>NP_003713
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 280 ITGRQSV 286
>NP_001108450
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 280 ITGRQSV 286
>NP_001108452
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 186 ITGRQSV 192
>NP_001108453
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 186 ITGRQSV 192
>NP_071750
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 433 LRQRQSLTS 441
>XP_005256148
          Length = 278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 225 LRQRQSLTS 233
>XP_006721307
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 317 LRQRQSLTS 325
>XP_005256144
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 433 LRQRQSLTS 441
>XP_005256143
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 433 LRQRQSLTS 441
>XP_005256142
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LTGRQSLTS 9
           L  RQSLTS
Sbjct: 433 LRQRQSLTS 441
>XP_005247903
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 280 ITGRQSV 286
>XP_005247901
          Length = 663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 263 ITGRQSV 269
>XP_005247900
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LTGRQSL 7
           +TGRQS+
Sbjct: 280 ITGRQSV 286
>XP_005273100
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          +TG+ SLTS
Sbjct: 23 VTGQLSLTS 31
>XP_006711797
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          +TG+ SLTS
Sbjct: 39 VTGQLSLTS 47
>XP_005273098
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          +TG+ SLTS
Sbjct: 68 VTGQLSLTS 76
>NP_444280
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LTGRQSLTS 9
          +TG+ SLTS
Sbjct: 68 VTGQLSLTS 76
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.117    0.287 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 404,834
Number of extensions: 431
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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