Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004110                                                              20     390
NP_060890                                                              18    1935
XP_006710817                                                           18    1935
XP_005271062                                                           18    1935
XP_005271061                                                           18    1935
XP_006710816                                                           18    1935
NP_001269723                                                           17    3301
NP_055705                                                              17    3301
NP_001269722                                                           17    3301
NP_001035924                                                           17    3301
NP_878913                                                              17    3301
XP_006713549                                                           17    3301
NP_542781                                                              16    5631
NP_005617                                                              16    7355
NP_008855                                                              16    7355
NP_001071634                                                           16    7355
NP_003760                                                              16    7355
XP_006722075                                                           16    7355
XP_005266998                                                           16    7355
NP_064592                                                              15    9605
NP_001010895                                                           15    9605
NP_055880                                                              15    9605
NP_000437                                                              15    9605
NP_001121361                                                           15    9605
NP_057714                                                              15    9605
NP_001121362                                                           15    9605
NP_997196                                                              15    9605
NP_660153                                                              15    9605
NP_001273148                                                           15    9605
NP_848018                                                              15    9605
NP_443139                                                              15    9605
XP_006721755                                                           15    9605
XP_005254494                                                           15    9605
XP_005254493                                                           15    9605
XP_006720627                                                           15    9605
XP_006719284                                                           15    9605
XP_006719283                                                           15    9605
XP_006719282                                                           15    9605
XP_005271520                                                           15    9605
XP_005271519                                                           15    9605
XP_005271518                                                           15    9605
XP_006717674                                                           15    9605
XP_006717673                                                           15    9605
XP_006717672                                                           15    9605
XP_005269546                                                           15    9605
XP_005269545                                                           15    9605
XP_006717671                                                           15    9605
XP_006717670                                                           15    9605
XP_006717669                                                           15    9605
XP_006717668                                                           15    9605
XP_006717667                                                           15    9605
NP_777568                                                              15    9605
>NP_004110
          Length = 993

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LTDAEEAMY 9
           L DAEEAMY
Sbjct: 947 LADAEEAMY 955
>NP_060890
          Length = 547

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LTDAEEAMY 9
           L++AEEA+Y
Sbjct: 258 LSEAEEALY 266
>XP_006710817
          Length = 315

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LTDAEEAMY 9
          L++AEEA+Y
Sbjct: 26 LSEAEEALY 34
>XP_005271062
          Length = 316

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  LTDAEEAMY 9
          L++AEEA+Y
Sbjct: 27 LSEAEEALY 35
>XP_005271061
          Length = 320

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LTDAEEAMY 9
           L++AEEA+Y
Sbjct: 258 LSEAEEALY 266
>XP_006710816
          Length = 476

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LTDAEEAMY 9
           L++AEEA+Y
Sbjct: 187 LSEAEEALY 195
>NP_001269723
          Length = 895

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 311 TDVEEKMY 318
>NP_055705
          Length = 893

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 311 TDVEEKMY 318
>NP_001269722
          Length = 711

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 127 TDVEEKMY 134
>NP_001035924
          Length = 1133

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 551 TDVEEKMY 558
>NP_878913
          Length = 1135

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 551 TDVEEKMY 558
>XP_006713549
          Length = 893

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD EE MY
Sbjct: 311 TDVEEKMY 318
>NP_542781
          Length = 261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DAEEAMY 9
          DAE+A+Y
Sbjct: 63 DAEDALY 69
>NP_005617
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LTDAEEAMY 9
          L DA++A+Y
Sbjct: 45 LRDADDAVY 53
>NP_008855
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DAEEAMY 9
          DAE+A+Y
Sbjct: 66 DAEDAVY 72
>NP_001071634
          Length = 201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DAEEAMY 9
          DAE+A+Y
Sbjct: 66 DAEDAVY 72
>NP_003760
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DAEEAMY 9
          DAE+A+Y
Sbjct: 64 DAEDAIY 70
>XP_006722075
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  DAEEAMY 9
          DAE+A+Y
Sbjct: 66 DAEDAVY 72
>XP_005266998
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TDAEEA 7
           TDAEEA
Sbjct: 610 TDAEEA 615
>NP_064592
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTDAEEAMY 9
           LTD ++A+Y
Sbjct: 403 LTDFQKAVY 411
>NP_001010895
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LTDAEEAMY 9
           LTD ++A+Y
Sbjct: 403 LTDFQKAVY 411
>NP_055880
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD + A Y
Sbjct: 853 LTDTQNAQY 861
>NP_000437
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TDAEEAMY 9
           TD + AMY
Sbjct: 121 TDEDNAMY 128
>NP_001121361
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 232 TEAKEEMY 239
>NP_057714
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 232 TEAKEEMY 239
>NP_001121362
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 205 TEAKEEMY 212
>NP_997196
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 794 LTDLEIGMY 802
>NP_660153
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1049 LTEAEDAL 1056
>NP_001273148
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 406 LTDLEIGMY 414
>NP_848018
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LTDAEEAMY 9
           +TD E+A Y
Sbjct: 447 MTDGEDADY 455
>NP_443139
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 894 LTDLEIGMY 902
>XP_006721755
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 788 LTDLEIGMY 796
>XP_005254494
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 232 TEAKEEMY 239
>XP_005254493
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 232 TEAKEEMY 239
>XP_006720627
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TDAEEAMY 9
           T+A+E MY
Sbjct: 232 TEAKEEMY 239
>XP_006719284
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 492 LTDLEIGMY 500
>XP_006719283
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 784 LTDLEIGMY 792
>XP_006719282
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD E  MY
Sbjct: 784 LTDLEIGMY 792
>XP_005271520
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD + A Y
Sbjct: 665 LTDTQNAQY 673
>XP_005271519
          Length = 1833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD + A Y
Sbjct: 697 LTDTQNAQY 705
>XP_005271518
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   LTDAEEAMY 9
           LTD + A Y
Sbjct: 846 LTDTQNAQY 854
>XP_006717674
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTDAEEAM 8
           LT+AE+A+
Sbjct: 857 LTEAEDAL 864
>XP_006717673
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTDAEEAM 8
           LT+AE+A+
Sbjct: 857 LTEAEDAL 864
>XP_006717672
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTDAEEAM 8
           LT+AE+A+
Sbjct: 857 LTEAEDAL 864
>XP_005269546
          Length = 929

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTDAEEAM 8
           LT+AE+A+
Sbjct: 857 LTEAEDAL 864
>XP_005269545
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LTDAEEAM 8
           LT+AE+A+
Sbjct: 979 LTEAEDAL 986
>XP_006717671
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1019 LTEAEDAL 1026
>XP_006717670
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1048 LTEAEDAL 1055
>XP_006717669
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1048 LTEAEDAL 1055
>XP_006717668
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1049 LTEAEDAL 1056
>XP_006717667
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LTDAEEAM 8
            LT+AE+A+
Sbjct: 1049 LTEAEDAL 1056
>NP_777568
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LTDAEEAMY 9
           +TD E+A Y
Sbjct: 271 MTDGEDADY 279
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.119    0.304 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 516,090
Number of extensions: 921
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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