Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     509
XP_005268094                                                           20     509
NP_002261                                                              17    3301
NP_694858                                                              17    3301
NP_001129668                                                           17    3301
NP_001129667                                                           17    3301
NP_038461                                                              17    3301
XP_005248557                                                           17    3301
XP_005248558                                                           17    3301
NP_071435                                                              17    4312
XP_005246819                                                           17    4312
XP_005246818                                                           17    4312
XP_005246815                                                           17    4312
NP_066918                                                              16    5631
NP_001158051                                                           16    5631
XP_006726675                                                           16    5631
XP_006712194                                                           16    5631
XP_006712193                                                           16    5631
XP_006712192                                                           16    5631
XP_006712191                                                           16    5631
NP_073732                                                              16    7355
NP_001243328                                                           16    7355
NP_061897                                                              16    7355
NP_114141                                                              16    7355
NP_057323                                                              16    7355
XP_006726569                                                           16    7355
XP_005256732                                                           16    7355
XP_006717414                                                           16    7355
XP_005264436                                                           16    7355
XP_006712098                                                           16    7355
XP_006712097                                                           16    7355
XP_006710281                                                           16    7355
NP_001036014                                                           16    7355
NP_001243330                                                           16    7355
NP_065103                                                              15    9605
NP_000320                                                              15    9605
NP_000677                                                              15    9605
NP_076985                                                              15    9605
NP_056288                                                              15    9605
NP_444504                                                              15    9605
NP_001157932                                                           15    9605
XP_006710874                                                           15    9605
XP_006710372                                                           15    9605
XP_005270458                                                           15    9605
XP_005270457                                                           15    9605
NP_071387                                                              15    9605
>NP_000360
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSYIVFVLT 9
           L+YIVFVLT
Sbjct: 580 LAYIVFVLT 588
>XP_005268094
          Length = 764

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LSYIVFVLT 9
           L+YIVFVLT
Sbjct: 580 LAYIVFVLT 588
>NP_002261
          Length = 898

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 56 NYLIFVLT 63
>NP_694858
          Length = 890

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 48 NYLIFVLT 55
>NP_001129668
          Length = 897

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 46 NYLIFVLT 53
>NP_001129667
          Length = 887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 46 NYLIFVLT 53
>NP_038461
          Length = 887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 46 NYLIFVLT 53
>XP_005248557
          Length = 890

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 48 NYLIFVLT 55
>XP_005248558
          Length = 866

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  SYIVFVLT 9
          +Y++FVLT
Sbjct: 56 NYLIFVLT 63
>NP_071435
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSYIVFVLT 9
           +SY VFV+T
Sbjct: 139 VSYAVFVVT 147
>XP_005246819
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSYIVFVLT 9
           +SY VFV+T
Sbjct: 139 VSYAVFVVT 147
>XP_005246818
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSYIVFVLT 9
           +SY VFV+T
Sbjct: 139 VSYAVFVVT 147
>XP_005246815
          Length = 311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSYIVFVLT 9
           +SY VFV+T
Sbjct: 139 VSYAVFVVT 147
>NP_066918
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>NP_001158051
          Length = 167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SYIVFVLT 9
           SY++FVL+
Sbjct: 142 SYVLFVLS 149
>XP_006726675
          Length = 167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SYIVFVLT 9
           SY++FVL+
Sbjct: 142 SYVLFVLS 149
>XP_006712194
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712193
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712192
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>XP_006712191
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          + Y+VFVL
Sbjct: 27 MDYVVFVL 34
>NP_073732
          Length = 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LSYIVFVLT 9
          L+Y+ FVL+
Sbjct: 36 LTYVYFVLS 44
>NP_001243328
          Length = 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LSYIVFVLT 9
          L+Y+ FVL+
Sbjct: 36 LTYVYFVLS 44
>NP_061897
          Length = 2071

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +Y+VFV T
Sbjct: 310 AYVVFVTT 317
>NP_114141
          Length = 5635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           S +VFVLT
Sbjct: 165 SQVVFVLT 172
>NP_057323
          Length = 3530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    YIVFVLT 9
            Y++FV+T
Sbjct: 3254 YVIFVVT 3260
>XP_006726569
          Length = 789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           S +VFVLT
Sbjct: 160 SQVVFVLT 167
>XP_005256732
          Length = 3531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    YIVFVLT 9
            Y++FV+T
Sbjct: 3255 YVIFVVT 3261
>XP_006717414
          Length = 5100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           S +VFVLT
Sbjct: 162 SQVVFVLT 169
>XP_005264436
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +Y+VFV T
Sbjct: 310 AYVVFVTT 317
>XP_006712098
          Length = 2059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +Y+VFV T
Sbjct: 298 AYVVFVTT 305
>XP_006712097
          Length = 2070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +Y+VFV T
Sbjct: 310 AYVVFVTT 317
>XP_006710281
          Length = 1303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           S +VFVLT
Sbjct: 133 SQVVFVLT 140
>NP_001036014
          Length = 213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           LSY+VF+
Sbjct: 186 LSYMVFI 192
>NP_001243330
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LSYIVFVLT 9
          L+Y+ FVL+
Sbjct: 36 LTYVYFVLS 44
>NP_065103
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSYIVFVL 8
           LSYI F+L
Sbjct: 330 LSYIPFLL 337
>NP_000320
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +YIVFV T
Sbjct: 248 NYIVFVET 255
>NP_000677
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LSYIVFVL 8
          L YI+FV+
Sbjct: 50 LYYIIFVI 57
>NP_076985
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LSYIVFVL 8
           L YI+F L
Sbjct: 834 LDYIIFTL 841
>NP_056288
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +Y+VFV T
Sbjct: 312 AYVVFVST 319
>NP_444504
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           L+Y+VFV
Sbjct: 289 LAYLVFV 295
>NP_001157932
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           SYI F+L+
Sbjct: 301 SYIYFILS 308
>XP_006710874
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SYIVFVLT 9
           +YIVFV T
Sbjct: 292 NYIVFVET 299
>XP_006710372
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           L+Y+VFV
Sbjct: 122 LAYLVFV 128
>XP_005270458
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           L+Y+VFV
Sbjct: 247 LAYLVFV 253
>XP_005270457
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           L+Y+VFV
Sbjct: 289 LAYLVFV 295
>NP_071387
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LSYIVFV 7
           LS+IVF+
Sbjct: 579 LSFIVFI 585
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.156    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 396,268
Number of extensions: 663
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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