Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_361014                                                              19     665
NP_001243998                                                           19     665
NP_001008563                                                           17    4312
NP_006667                                                              17    4312
NP_001103773                                                           17    4312
XP_005251723                                                           17    4312
XP_006717001                                                           17    4312
XP_005251722                                                           17    4312
XP_006713297                                                           17    4312
XP_006713296                                                           17    4312
XP_006713295                                                           17    4312
XP_005265345                                                           17    4312
XP_006713294                                                           17    4312
XP_006713293                                                           17    4312
XP_006713292                                                           17    4312
XP_006713291                                                           17    4312
XP_006713290                                                           17    4312
XP_006713289                                                           17    4312
XP_006713286                                                           17    4312
XP_005265332                                                           17    4312
XP_006713285                                                           17    4312
XP_006713284                                                           17    4312
XP_006713283                                                           17    4312
NP_056139                                                              16    5631
NP_001185731                                                           16    5631
NP_001185730                                                           16    5631
NP_003751                                                              16    5631
XP_006716126                                                           16    5631
XP_005250566                                                           16    5631
XP_005250565                                                           16    5631
NP_001120832                                                           16    5631
NP_001120831                                                           16    5631
NP_001120829                                                           16    5631
NP_001120830                                                           16    5631
NP_065165                                                              16    5631
NP_002838                                                              16    7355
XP_006716138                                                           16    7355
NP_570857                                                              16    7355
NP_570858                                                              16    7355
NP_001073893                                                           15    9605
NP_775859                                                              15    9605
NP_997253                                                              15    9605
NP_002636                                                              15    9605
XP_006721547                                                           15    9605
XP_005256611                                                           15    9605
XP_005256609                                                           15    9605
XP_005256607                                                           15    9605
XP_005256608                                                           15    9605
XP_006721546                                                           15    9605
XP_005256606                                                           15    9605
XP_005253037                                                           15    9605
XP_005253036                                                           15    9605
XP_005253035                                                           15    9605
XP_005253034                                                           15    9605
XP_005248275                                                           15    9605
XP_003846701                                                           15    9605
>NP_361014
          Length = 707

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LSVGSKRRQ 9
          LSVGSKRR+
Sbjct: 6  LSVGSKRRR 14
>NP_001243998
          Length = 176

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LSVGSKRRQ 9
          LSVGSKRR+
Sbjct: 6  LSVGSKRRR 14
>NP_001008563
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 429 LSAGSRRRK 437
>NP_006667
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 429 LSAGSRRRK 437
>NP_001103773
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 429 LSAGSRRRK 437
>XP_005251723
          Length = 675

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 190 LSAGSRRRK 198
>XP_006717001
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 429 LSAGSRRRK 437
>XP_005251722
          Length = 914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           LS GS+RR+
Sbjct: 429 LSAGSRRRK 437
>XP_006713297
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713296
          Length = 1615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713295
          Length = 1620

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_005265345
          Length = 1627

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713294
          Length = 1652

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713293
          Length = 1667

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713292
          Length = 1670

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713291
          Length = 1682

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713290
          Length = 1690

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713289
          Length = 1697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713286
          Length = 1707

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_005265332
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713285
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713284
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>XP_006713283
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  SVGSKRRQ 9
          S+GSKRR+
Sbjct: 18 SMGSKRRR 25
>NP_056139
          Length = 456

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  GSKRRQ 9
          GSKRRQ
Sbjct: 34 GSKRRQ 39
>NP_001185731
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           L+VGS+R Q
Sbjct: 703 LNVGSRRSQ 711
>NP_001185730
          Length = 1621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           L+VGS+R Q
Sbjct: 733 LNVGSRRSQ 741
>NP_003751
          Length = 1585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSVGSKRRQ 9
           L+VGS+R Q
Sbjct: 697 LNVGSRRSQ 705
>XP_006716126
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 162 LSTGGKRRR 170
>XP_005250566
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 162 LSTGGKRRR 170
>XP_005250565
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 162 LSTGGKRRR 170
>NP_001120832
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 158 LSTGGKRRR 166
>NP_001120831
          Length = 356

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 162 LSTGGKRRR 170
>NP_001120829
          Length = 751

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 162 LSTGGKRRR 170
>NP_001120830
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 158 LSTGGKRRR 166
>NP_065165
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 158 LSTGGKRRR 166
>NP_002838
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVGSKRR 8
           SVGS+RR
Sbjct: 132 SVGSERR 138
>XP_006716138
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVGSKRR 8
           SVGS+RR
Sbjct: 132 SVGSERR 138
>NP_570857
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVGSKRR 8
           SVGS+RR
Sbjct: 115 SVGSERR 121
>NP_570858
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SVGSKRR 8
           SVGS+RR
Sbjct: 132 SVGSERR 138
>NP_001073893
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>NP_775859
          Length = 1326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSVGSKR 7
           LSVG KR
Sbjct: 310 LSVGDKR 316
>NP_997253
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  LSVGSKRRQ 9
          LSVG+K+++
Sbjct: 30 LSVGAKQKK 38
>NP_002636
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LSVGSKR 7
            LSVG KR
Sbjct: 1035 LSVGGKR 1041
>XP_006721547
          Length = 1638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005256611
          Length = 1643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005256609
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005256607
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005256608
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_006721546
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005256606
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LS G KRR+
Sbjct: 223 LSPGGKRRR 231
>XP_005253037
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LSVGSKR 7
           LSVG KR
Sbjct: 655 LSVGGKR 661
>XP_005253036
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LSVGSKR 7
            LSVG KR
Sbjct: 1035 LSVGGKR 1041
>XP_005253035
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LSVGSKR 7
            LSVG KR
Sbjct: 1035 LSVGGKR 1041
>XP_005253034
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LSVGSKR 7
            LSVG KR
Sbjct: 1035 LSVGGKR 1041
>XP_005248275
          Length = 136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VGSKRRQ 9
           VG+KR+Q
Sbjct: 127 VGNKRKQ 133
>XP_003846701
          Length = 143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LSVGSKRRQ 9
           LSVG K+ Q
Sbjct: 132 LSVGKKQAQ 140
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.126    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 586,970
Number of extensions: 951
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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